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Graded
Domain 1: Nutrition Fundamentals & Macronutrients (20 Questions)
Q1: A 28-year-old male endurance athlete (70 kg) consumes a diet providing 2,800
kcal/day with 45% carbohydrate, 25% protein, and 30% fat. Based on ISSA guidelines for
endurance athletes, which macronutrient adjustment would most likely optimize his
performance?
A. Decrease carbohydrate to 35% and increase protein to 35% to enhance fat oxidation
B. Maintain current intake as it falls within acceptable macronutrient distribution ranges
(AMDR)
C. Increase carbohydrate to 55-65% and adjust protein to 15-20% to maximize glycogen
storage
D. Decrease fat to 15% and increase protein to 40% for improved body composition
Correct Answer: C
Rationale: Endurance athletes require 55-65% of calories from carbohydrate (5-8
g/kg/day) to maintain muscle glycogen stores for prolonged activity. The current 45%
(approximately 315 g or 4.5 g/kg) is insufficient for optimal performance. Protein at 25%
(175 g or 2.5 g/kg) exceeds endurance athlete needs (1.2-1.4 g/kg); reducing to 15-20%
(1.2-1.6 g/kg) while increasing carbohydrate better supports training demands. Option A
reduces carbohydrate below requirements, impairing performance. Option B is incorrect
because while 45% carbohydrate meets AMDR for general population (45-65%), athletes
have higher needs. Option D's 15% fat falls below essential fatty acid requirements
,(minimum 20%) and 40% protein offers no performance benefit while displacing
carbohydrate. [CORRECT]
Q2: A client following a vegan diet struggles to meet leucine requirements for muscle
protein synthesis. Which food combination provides the most effective complete
protein profile?
A. Brown rice and almonds
B. Lentils and quinoa
C. Chickpeas and whole wheat pita
D. Peanut butter and whole grain bread
Correct Answer: B
Rationale: Lentils and quinoa provide complementary amino acid profiles with quinoa
contributing sufficient lysine (limiting in legumes) and lentils providing methionine
(limiting in grains). Quinoa is a complete protein itself, containing all essential amino
acids in favorable ratios, while lentils are leucine-rich. This combination maximizes the
leucine threshold (2.5-3g) for muscle protein synthesis. Brown rice/almonds (A) lacks
lysine and is methionine-heavy. Chickpeas/pita (C) improves amino acid score but
quinoa has superior protein quality (PDCAAS ~0.9 vs. wheat ~0.4). Peanut butter/bread
(D) is lysine-deficient and lower in total protein. [CORRECT]
Q3: A 45-year-old female client has elevated LDL cholesterol (160 mg/dL) and family
history of cardiovascular disease. Which dietary fat modification aligns with ISSA
recommendations and AHA guidelines?
A. Replace all dietary fats with coconut oil for its medium-chain triglyceride content
B. Eliminate dietary cholesterol completely and consume only egg whites
C. Substitute saturated fats with polyunsaturated and monounsaturated fats from nuts,
seeds, and fatty fish
,D. Adopt a very-low-fat diet (<10% calories from fat) to maximize LDL reduction
Correct Answer: C
Rationale: Replacing saturated fats with unsaturated fats reduces LDL cholesterol by
8-10% and cardiovascular events by 17-21% (Cochrane Review, 2020). Polyunsaturated
fats (omega-3 and omega-6) lower LDL and triglycerides while maintaining HDL.
Coconut oil (A) is 92% saturated fat and raises LDL. Complete cholesterol elimination
(B) is unnecessary—dietary cholesterol has modest impact on serum cholesterol for
most individuals. Very-low-fat diets (D) often increase triglycerides, reduce HDL, and are
unsustainable; they also impair absorption of fat-soluble vitamins. [CORRECT]
Q4: During high-intensity exercise (>75% VO2 max), which substrate provides the
predominant energy source for working muscles?
A. Plasma free fatty acids
B. Muscle triglycerides
C. Blood glucose and muscle glycogen
D. Ketone bodies
Correct Answer: C
Rationale: At exercise intensities >75% VO2 max, the rate of ATP demand exceeds fat
oxidation capacity. Carbohydrate becomes the primary fuel—blood glucose and muscle
glycogen provide rapid glycolytic ATP production. The crossover concept demonstrates
that as intensity increases, carbohydrate oxidation increases while fat oxidation
decreases. Free fatty acids (A) require oxygen and transport proteins; oxidation is too
slow for high intensity. Muscle triglycerides (B) contribute but are secondary to
carbohydrate. Ketone bodies (D) are minimal during high-intensity exercise due to
suppressed lipolysis and ketogenesis. [CORRECT]
, Q5: A client consumes 2,000 kcal/day with 300g carbohydrate, 75g protein, and 67g fat.
What is the protein percentage of total energy intake?
A. 12%
B. 15%
C. 18%
D. 20%
Correct Answer: B
Rationale: Calculation: 75g protein × 4 kcal/g = 300 kcal from protein. 300 ÷ 2,000 =
0.15 or 15%. Carbohydrate provides 1,200 kcal (60%), fat provides 603 kcal (33.4%).
This falls within the AMDR for protein (10-35%) and meets general population needs
(0.8 g/kg), though athletes require higher percentages. [CORRECT]
Q6: Which type of dietary fiber forms a viscous gel in the gastrointestinal tract, slowing
gastric emptying and reducing postprandial blood glucose response?
A. Cellulose
B. Hemicellulose
C. Beta-glucan
D. Lignin
Correct Answer: C
Rationale: Beta-glucan (found in oats, barley, mushrooms) is a viscous, soluble fiber that
forms gel-like matrices, delaying gastric emptying, reducing glucose absorption rate,
and lowering postprandial insulin response (FDA-approved health claim: 3g/day reduces
heart disease risk). Cellulose (A) and hemicellulose (B) are insoluble fibers that add bulk
and speed transit. Lignin (D) is a non-carbohydrate insoluble fiber. The viscosity of