Lupus NCLEX Practice Questions and
Answers (Top Grade Assured) 2026
Update
The nurse is preparing a presentation on systemic lupus
erythematosus (SLE). Which statement should the nurse
include? (Select all that apply.)
A. The etiology is known to be linked to environmental
factors.
B. Manifestations can be mild to fatal, with remissions and
exacerbations.
C. The immune complex deposits trigger an inflammatory
response.
D. SLE is a result of deposition of antigen-antibody complexes
in connective tissues.
E. The inflammatory response leads to anaphylactic shock. -
Correct Answers ✅B. Manifestations can be mild to fatal,
with remissions and exacerbations.
C. The immune complex deposits trigger an inflammatory
response.
D. SLE is a result of deposition of antigen-antibody complexes
in connective tissues.
The pathophysiology of systemic lupus erythematosus is a
result of the formation of
antigen-antibody immunocomplexes that are deposited in the
connective tissue and trigger an inflammatory response. The
manifestations of the disease can be mild to fatal, and
remissions are followed by exacerbations. The inflammatory
response leads to tissue damage but not anaphylactic shock
,Lupus NCLEX Practice Questions and
Answers (Top Grade Assured) 2026
Update
(allergic reaction). Although the exact etiology of SLE is
unknown, genetic, ethnic, environmental, and hormonal
factors play a role in its development.
The nurse is assessing a client with systemic lupus
erythematosus (SLE). Which clinical manifestation should the
nurse expect to observe? (Select all that apply.)
A. Red butterfly rash on the face
B. Alopecia
C. Psoriatic lesions
D. Painful or swollen joints
E. Leg and eye edema - Correct Answers ✅A. Red butterfly
rash on the face
B. Alopecia
D. Painful or swollen joints
E. Leg and eye edema
Rationale: Painful swollen joints, alopecia, red butterfly rash
on the face, and leg and eye edema are all characteristics of
SLE. Psoriatic lesions are caused by psoriasis, which is an
autoimmune disease characterized by patches of abnormal
skin.
, Lupus NCLEX Practice Questions and
Answers (Top Grade Assured) 2026
Update
The nurse is assessing a client with systemic lupus
erythematosus (SLE). Which manifestation should the nurse
recognize as a result of inflammation? (Select all that apply.)
A. Cough
B. Malaise
C. Maculopapular rash
D. Joint pain
E.Fever - Correct Answers ✅B. Malaise
C. Maculopapular rash
D. Joint pain
E. Fever
In SLE, the immunocomplexes that are deposited in the
connective tissue trigger an inflammatory response. Joint
pain, fever, malaise, and maculopapular rash are all signs of
the inflammation that result from local tissue damage. A
cough is a sign of infection, not of inflammation resulting
from tissue damage.
A client diagnosed with systemic lupus erythematosus (SLE)
is experiencing pulmonary interstitial fibrosis. Which
classification of lupus should the nurse suspect?
Answers (Top Grade Assured) 2026
Update
The nurse is preparing a presentation on systemic lupus
erythematosus (SLE). Which statement should the nurse
include? (Select all that apply.)
A. The etiology is known to be linked to environmental
factors.
B. Manifestations can be mild to fatal, with remissions and
exacerbations.
C. The immune complex deposits trigger an inflammatory
response.
D. SLE is a result of deposition of antigen-antibody complexes
in connective tissues.
E. The inflammatory response leads to anaphylactic shock. -
Correct Answers ✅B. Manifestations can be mild to fatal,
with remissions and exacerbations.
C. The immune complex deposits trigger an inflammatory
response.
D. SLE is a result of deposition of antigen-antibody complexes
in connective tissues.
The pathophysiology of systemic lupus erythematosus is a
result of the formation of
antigen-antibody immunocomplexes that are deposited in the
connective tissue and trigger an inflammatory response. The
manifestations of the disease can be mild to fatal, and
remissions are followed by exacerbations. The inflammatory
response leads to tissue damage but not anaphylactic shock
,Lupus NCLEX Practice Questions and
Answers (Top Grade Assured) 2026
Update
(allergic reaction). Although the exact etiology of SLE is
unknown, genetic, ethnic, environmental, and hormonal
factors play a role in its development.
The nurse is assessing a client with systemic lupus
erythematosus (SLE). Which clinical manifestation should the
nurse expect to observe? (Select all that apply.)
A. Red butterfly rash on the face
B. Alopecia
C. Psoriatic lesions
D. Painful or swollen joints
E. Leg and eye edema - Correct Answers ✅A. Red butterfly
rash on the face
B. Alopecia
D. Painful or swollen joints
E. Leg and eye edema
Rationale: Painful swollen joints, alopecia, red butterfly rash
on the face, and leg and eye edema are all characteristics of
SLE. Psoriatic lesions are caused by psoriasis, which is an
autoimmune disease characterized by patches of abnormal
skin.
, Lupus NCLEX Practice Questions and
Answers (Top Grade Assured) 2026
Update
The nurse is assessing a client with systemic lupus
erythematosus (SLE). Which manifestation should the nurse
recognize as a result of inflammation? (Select all that apply.)
A. Cough
B. Malaise
C. Maculopapular rash
D. Joint pain
E.Fever - Correct Answers ✅B. Malaise
C. Maculopapular rash
D. Joint pain
E. Fever
In SLE, the immunocomplexes that are deposited in the
connective tissue trigger an inflammatory response. Joint
pain, fever, malaise, and maculopapular rash are all signs of
the inflammation that result from local tissue damage. A
cough is a sign of infection, not of inflammation resulting
from tissue damage.
A client diagnosed with systemic lupus erythematosus (SLE)
is experiencing pulmonary interstitial fibrosis. Which
classification of lupus should the nurse suspect?
