Wilkes Exam 3 Study Guide Fall
2026 Exam Questions and
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First Line Treatments for alcohol use disorder (according to Study Guide &
Dynamed) - 🧠 ANSWER ✔✔naltrexone and acamprosate
, Second Line Treatments for alcohol use disorder (according to study guide
but not dynamed) - 🧠 ANSWER ✔✔Disulfuram and Bupropion (not FDA
approved for ETOH but second line according to study guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) - 🧠
ANSWER ✔✔Disulfuram
Other off label medications for alcohol use disorder according to Dynamed
- 🧠 ANSWER ✔✔Topiramate, gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's - 🧠
ANSWER ✔✔Topiramate, ondansetron
MOA of Naltrexone - 🧠 ANSWER ✔✔Opioid Receptor Antagonist
MOA of Acamprosate - 🧠 ANSWER ✔✔- weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - 🧠 ANSWER ✔✔inhibits enzyme (aldehyde
dehydrogenase) in the liver