Patho – Osteoporosis EXAM
LATEST QUESTIONS AND
VERIFIED CORRECT
ANSWERS
Hormones that DECREASE RANKL - correct answer These DECREASE cytokines like RANKL:
- TGF-B (growth factor)
-17B-estradiol (estrogen)
OPG (osteoprotegrin) - correct answer OPG _ a glycoprotein - decreases the risk of osteoporosis
- attaches to teh same receptors on clast cells and blocks RANKL = clasts die through apoptosis
(normal life span)
Hormones that INCREASE OPG - correct answer -TGF
-17-B estradoil
Hormones that DECREASE OPG - correct answer -PTH
-PgE2
-glucocorticoids
Common early signs of Osteoporosis - correct answer -Back pain (r/t altered vertebra causing
pressure on nerves
-kyphosis / scoliosis (r/t vertebrae becoming compressed)
-Compression fractures of vertebrae
-Spontaneous fractures of head of femur
, **slow healing of fractures due to poor functioning of blasts needed to heal fracture
Osteoporosis r/t Menopause - correct answer Loss of estrogen => increased RANKL =
suppressed clasts apoptosis
- Estrogen = promotes apoptosis of clasts,
anti -apoptotic for blasts
Loss of Estrogen = decreased OPG, longer clast life span
Steroids r/t Osteoporosis - correct answer Glucocorticoids :
-increase RANKL
-decrease OPG
Steroids induce osteoporosis
OP: Men vs Women - correct answer Men and women have different balance of hormones
-(why hormone replacement can be helpful for women)
Men preserve bone mass longer
-greater peak bone mass
-have androgenic stimulation of OPG (clast inhibition)
Osteomyelitis - correct answer Bone infection:
-Usually bacterial (can be fungal, viral, or parasitic)
-Comes from either Endogenous/hematogenous source * or * Exogenous source
Endogenous Osteomyelitis - correct answer Comes from another source inside the body:
Pathogen travels through the blood stream to the bone / site of infection.
-Soft tissue infection travels to bone by blood
LATEST QUESTIONS AND
VERIFIED CORRECT
ANSWERS
Hormones that DECREASE RANKL - correct answer These DECREASE cytokines like RANKL:
- TGF-B (growth factor)
-17B-estradiol (estrogen)
OPG (osteoprotegrin) - correct answer OPG _ a glycoprotein - decreases the risk of osteoporosis
- attaches to teh same receptors on clast cells and blocks RANKL = clasts die through apoptosis
(normal life span)
Hormones that INCREASE OPG - correct answer -TGF
-17-B estradoil
Hormones that DECREASE OPG - correct answer -PTH
-PgE2
-glucocorticoids
Common early signs of Osteoporosis - correct answer -Back pain (r/t altered vertebra causing
pressure on nerves
-kyphosis / scoliosis (r/t vertebrae becoming compressed)
-Compression fractures of vertebrae
-Spontaneous fractures of head of femur
, **slow healing of fractures due to poor functioning of blasts needed to heal fracture
Osteoporosis r/t Menopause - correct answer Loss of estrogen => increased RANKL =
suppressed clasts apoptosis
- Estrogen = promotes apoptosis of clasts,
anti -apoptotic for blasts
Loss of Estrogen = decreased OPG, longer clast life span
Steroids r/t Osteoporosis - correct answer Glucocorticoids :
-increase RANKL
-decrease OPG
Steroids induce osteoporosis
OP: Men vs Women - correct answer Men and women have different balance of hormones
-(why hormone replacement can be helpful for women)
Men preserve bone mass longer
-greater peak bone mass
-have androgenic stimulation of OPG (clast inhibition)
Osteomyelitis - correct answer Bone infection:
-Usually bacterial (can be fungal, viral, or parasitic)
-Comes from either Endogenous/hematogenous source * or * Exogenous source
Endogenous Osteomyelitis - correct answer Comes from another source inside the body:
Pathogen travels through the blood stream to the bone / site of infection.
-Soft tissue infection travels to bone by blood
