MN 553 FINAL PAPER 2026 QUESTIONS AND
SOLUTIONS EXAMPREP GRADED A+
▶ Clinical uses of cholinesterase inhibitors. Answer: MG
Alzeheimer's
▶ Cholinergic blockers rational drug selection. Answer: Scopolamine
Ipratropium bromide
Benztropine
Oxybutynin
▶ What is another term for anticonvulsants. Answer: Hydantoins
▶ Examples of anticonvulsants. Answer: Ethotoin
Fosphenytoin
Phenytoin
Lamotrigine
▶ Clinical uses for lamotrigine. Answer: Used in adjunctive treatment of
primary generalized tonic clonic seizures and partial seizures in adults and
children older than 2 years of age
Concurrently used with valproic acid and phenytoin
▶ Examples of nonselective norepinephrine serotonin reuptake inhibitors.
Answer: TCAs
,Amitriptyline, nortriptyline, imipramine, doxepin, trimipramine maleate,
amoxapine, desipramine, protriptyline hydrochloride, clomipramine
▶ Examples of MAOIs. Answer: Phelenzine, isocarboxazid,
tranylcypromine
▶ Examples of SSRIs. Answer: Fluoxetine, olanzapine-fluoxetine,
paroxetine, sertraline, fluvoxamine, citalopram, escitralopram
▶ Examples of serotonin -norepinephrine reuptake inhibitors (SNRIs).
Answer: Venlafaxine (Effexor), duloxetine, (Cymbalta), milnacipran
(Savella), desvenlafaxine (Pristig)
▶ Clinical use for TCAs. Answer: Nocturnal enuresis
Intractable pain
Anxiety disorders.
▶ Pharmacodynamics of TCAs. Answer: Act on neurotransmitters
serotonin and norepinephrine and histamine and acetylchoine
▶ Pharmacokinetics of TCAs. Answer: Fairly long half life of 6-18 hours
Liver metabolism strong CYP2D6
▶ What should the treatment for depression always include. Answer:
Referral for psychological therapy
▶ Treatment for pediatric depression. Answer: Fluoxetine (Prozac)
▶ Why are MAOIs avoided. Answer: Low safety margin
Not a first line drug
Many drug-drug , food- drug interactions
▶ SSRI pharmacodynamics. Answer: Selective inhibitory effects on
presynaptic serotonin reuptake
, ▶ SSRI pharmacokinetics. Answer: Slow absorption
Half-life 26 hours
Extensive first pass metabolism
▶ Fluoxetine half life. Answer: 1-3 days
▶ Fluoxetine first metabolite. Answer: 4-16 days
▶ SSRI ADRs. Answer: CNS
GI
Sexual dysfunction
Serotonin syndrome
▶ SSRI patient education. Answer: Pregnancy category B, C, or D
Withdrawal symptoms if abruptly discontinued
Avoid St. johns wort
▶ SSRI monitoring. Answer: Never give more than 4 weeks on first
prescription
Monitor target symptoms
▶ SNRI clinical uses. Answer: Major depressive disorder
GAD
Neuropathy
Pain
Fibromyalgia
▶ True or false
SOLUTIONS EXAMPREP GRADED A+
▶ Clinical uses of cholinesterase inhibitors. Answer: MG
Alzeheimer's
▶ Cholinergic blockers rational drug selection. Answer: Scopolamine
Ipratropium bromide
Benztropine
Oxybutynin
▶ What is another term for anticonvulsants. Answer: Hydantoins
▶ Examples of anticonvulsants. Answer: Ethotoin
Fosphenytoin
Phenytoin
Lamotrigine
▶ Clinical uses for lamotrigine. Answer: Used in adjunctive treatment of
primary generalized tonic clonic seizures and partial seizures in adults and
children older than 2 years of age
Concurrently used with valproic acid and phenytoin
▶ Examples of nonselective norepinephrine serotonin reuptake inhibitors.
Answer: TCAs
,Amitriptyline, nortriptyline, imipramine, doxepin, trimipramine maleate,
amoxapine, desipramine, protriptyline hydrochloride, clomipramine
▶ Examples of MAOIs. Answer: Phelenzine, isocarboxazid,
tranylcypromine
▶ Examples of SSRIs. Answer: Fluoxetine, olanzapine-fluoxetine,
paroxetine, sertraline, fluvoxamine, citalopram, escitralopram
▶ Examples of serotonin -norepinephrine reuptake inhibitors (SNRIs).
Answer: Venlafaxine (Effexor), duloxetine, (Cymbalta), milnacipran
(Savella), desvenlafaxine (Pristig)
▶ Clinical use for TCAs. Answer: Nocturnal enuresis
Intractable pain
Anxiety disorders.
▶ Pharmacodynamics of TCAs. Answer: Act on neurotransmitters
serotonin and norepinephrine and histamine and acetylchoine
▶ Pharmacokinetics of TCAs. Answer: Fairly long half life of 6-18 hours
Liver metabolism strong CYP2D6
▶ What should the treatment for depression always include. Answer:
Referral for psychological therapy
▶ Treatment for pediatric depression. Answer: Fluoxetine (Prozac)
▶ Why are MAOIs avoided. Answer: Low safety margin
Not a first line drug
Many drug-drug , food- drug interactions
▶ SSRI pharmacodynamics. Answer: Selective inhibitory effects on
presynaptic serotonin reuptake
, ▶ SSRI pharmacokinetics. Answer: Slow absorption
Half-life 26 hours
Extensive first pass metabolism
▶ Fluoxetine half life. Answer: 1-3 days
▶ Fluoxetine first metabolite. Answer: 4-16 days
▶ SSRI ADRs. Answer: CNS
GI
Sexual dysfunction
Serotonin syndrome
▶ SSRI patient education. Answer: Pregnancy category B, C, or D
Withdrawal symptoms if abruptly discontinued
Avoid St. johns wort
▶ SSRI monitoring. Answer: Never give more than 4 weeks on first
prescription
Monitor target symptoms
▶ SNRI clinical uses. Answer: Major depressive disorder
GAD
Neuropathy
Pain
Fibromyalgia
▶ True or false
