NSG 6005 Pharm Weeks 1-3
Quiz (from operationFNP Class
11) EXAM QUESTIONS AND
ANSWERS LATEST
Carbamazepine has a Black Box Warning recommending testing for the HLA-
B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
1. Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-
B*1502 allele
2. Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
3. Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 allele
4. Patients who have the HLA-B*1502 allele being more likely to have a resistance to
carbamazepine - CORRECT ANSWER3. Increased risk for Stevens-Johnson syndrome in Asian
patients with HLA-B*1502 allele
A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by
the body may lead to:
1. Decreased effectiveness of irinotecan in the treatment of cancer
,2. Increased adverse drug reactions, such as neutropenia
3. Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
4. Increased concerns for irinotecan being carcinogenic - CORRECT ANSWER2. Increased
adverse drug reactions, such as neutropenia
Patients who have a poor metabolism phenotype will have:
1. Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug
2. Accumulation of inactive metabolites of drugs
3. A need for increased dosages of medications
4. Increased elimination of an active drug - CORRECT ANSWER1. Slowed metabolism of a
prodrug into an active drug, leading to accumulation of prodrug
Ultra-rapid metabolizers of drugs may have:
1. To have dosages of drugs adjusted downward to prevent drug accumulation
2. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic
failure
3. Increased elimination of active, nonmetabolized drug
,4. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug -
CORRECT ANSWER2. Active drug rapidly metabolized into inactive metabolites, leading to
potential therapeutic failure
A provider may consider testing for CYP2D6 variants prior to starting tamoxifen for breast
cancer to:
1. Ensure the patient will not have increased adverse drug reactions to the tamoxifen
2. Identify potential drug-drug interactions that may occur with tamoxifen
3. Reduce the likelihood of therapeutic failure with tamoxifen treatment
4. Identify poor metabolizers of tamoxifen - CORRECT ANSWER3. Reduce the likelihood of
therapeutic failure with tamoxifen treatment
The most frequent type of drug-food interaction is food:
1. Causing increased therapeutic drug levels
2. Affecting the metabolism of the drug
3. Altering the volume of distribution of drugs
4. Affecting the gastrointestinal absorption of drugs - CORRECT ANSWER4. Affecting the
gastrointestinal absorption of drugs
, Food in the gastrointestinal tract affects drug absorption by:
1. Altering the pH of the colon, which decreases absorption
2. Competing with the drug for plasma proteins
3. Altering gastric emptying time
4. Altering the pH of urine - CORRECT ANSWER3. Altering gastric emptying time
Food can alter the pH of the stomach, leading to:
1. Enhanced drug metabolism
2. Altered vitamin K absorption
3. Increased vitamin D absorption
4. Altered drug bioavailability - CORRECT ANSWER4. Altered drug bioavailability
Fasting for an extended period can:
1. Increase drug absorption due to lack of competition between food and the drug
2. Alter the pH of the gastrointestinal tract, affecting absorption
Quiz (from operationFNP Class
11) EXAM QUESTIONS AND
ANSWERS LATEST
Carbamazepine has a Black Box Warning recommending testing for the HLA-
B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
1. Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-
B*1502 allele
2. Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
3. Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 allele
4. Patients who have the HLA-B*1502 allele being more likely to have a resistance to
carbamazepine - CORRECT ANSWER3. Increased risk for Stevens-Johnson syndrome in Asian
patients with HLA-B*1502 allele
A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by
the body may lead to:
1. Decreased effectiveness of irinotecan in the treatment of cancer
,2. Increased adverse drug reactions, such as neutropenia
3. Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
4. Increased concerns for irinotecan being carcinogenic - CORRECT ANSWER2. Increased
adverse drug reactions, such as neutropenia
Patients who have a poor metabolism phenotype will have:
1. Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug
2. Accumulation of inactive metabolites of drugs
3. A need for increased dosages of medications
4. Increased elimination of an active drug - CORRECT ANSWER1. Slowed metabolism of a
prodrug into an active drug, leading to accumulation of prodrug
Ultra-rapid metabolizers of drugs may have:
1. To have dosages of drugs adjusted downward to prevent drug accumulation
2. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic
failure
3. Increased elimination of active, nonmetabolized drug
,4. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug -
CORRECT ANSWER2. Active drug rapidly metabolized into inactive metabolites, leading to
potential therapeutic failure
A provider may consider testing for CYP2D6 variants prior to starting tamoxifen for breast
cancer to:
1. Ensure the patient will not have increased adverse drug reactions to the tamoxifen
2. Identify potential drug-drug interactions that may occur with tamoxifen
3. Reduce the likelihood of therapeutic failure with tamoxifen treatment
4. Identify poor metabolizers of tamoxifen - CORRECT ANSWER3. Reduce the likelihood of
therapeutic failure with tamoxifen treatment
The most frequent type of drug-food interaction is food:
1. Causing increased therapeutic drug levels
2. Affecting the metabolism of the drug
3. Altering the volume of distribution of drugs
4. Affecting the gastrointestinal absorption of drugs - CORRECT ANSWER4. Affecting the
gastrointestinal absorption of drugs
, Food in the gastrointestinal tract affects drug absorption by:
1. Altering the pH of the colon, which decreases absorption
2. Competing with the drug for plasma proteins
3. Altering gastric emptying time
4. Altering the pH of urine - CORRECT ANSWER3. Altering gastric emptying time
Food can alter the pH of the stomach, leading to:
1. Enhanced drug metabolism
2. Altered vitamin K absorption
3. Increased vitamin D absorption
4. Altered drug bioavailability - CORRECT ANSWER4. Altered drug bioavailability
Fasting for an extended period can:
1. Increase drug absorption due to lack of competition between food and the drug
2. Alter the pH of the gastrointestinal tract, affecting absorption
