PHARMACOLOGY USMLE STEP 1 EXAM
COMPLETE QUESTIONS WITH CORRECT
ANSWERS
What are the major functions of the M3 receptor? - CORRECT
ANSWER>>>>Increase
exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut
peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary
sphincter muscle contraction (miosis), ciliary muscle contraction
(accommodation)
What are the major functions of the D1 receptor? - CORRECT
ANSWER>>>>Relaxes renal
vascular smooth
muscle
What are the major functions of the D2 receptor? - CORRECT
ANSWER>>>>Modulates
transmitter release, especially in
the brain
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,What are the major functions of the H1 receptor? - CORRECT
ANSWER>>>>Increase nasal and bronchial mucus production, increase vascular
permeability, contraction of bronchioles, pruritis, pain
What are the major functions of the H2 receptor? - CORRECT
ANSWER>>>>Increase gastric
acid
secretion
What are the major functions of the V1 receptor? - CORRECT
ANSWER>>>>Increase vascular
smooth muscle
contraction
What are the major functions of the V2 receptor? - CORRECT
ANSWER>>>>Increase H2O
permeability and reabsorption in collecting tubules of kidney (V2 is found in
the "2" kidneys)
What are the major functions of the α1 receptor? - CORRECT
ANSWER>>>>Increase vascular smooth muscle contraction, increase pupillary
dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter
muscle contraction
What are the major functions of the α2 receptor? - CORRECT
ANSWER>>>>Decrease sympathetic outflow, decrease insulin release,
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,decrease lipolysis, increase platelet aggregation, decrease aqueous humor
production
What are the major functions of the β1 receptor? - CORRECT
ANSWER>>>>Increase heart
rate, increase contractility, increase renin release,
increase lipolysis
What are the major functions of the β2 receptor? - CORRECT
ANSWER>>>>Vasodilation,
bronchodilation, increase lipolysis, increase insulin release, decrease uterine
tone (tocolysis),
ciliary muscle relaxation, increase aqueous humor
production
What are the major functions of the M1 receptor? - CORRECT
ANSWER>>>>CNS, enteric
nervous
system
What are the major functions of the M2 receptor? - CORRECT
ANSWER>>>>Decrease heart
rate and contractility of
atria
What receptors are associate with Gq? - CORRECT ANSWER>>>>H1, α1, V1,
M1, and M3
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, What receptors are associated with Gs? - CORRECT ANSWER>>>>H2, B1, B2,
V2, D1
What receptors are associated with Gi? - CORRECT ANSWER>>>>M2, α2, D2
Bethanechol - CORRECT ANSWER>>>>-Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE
Carbachol - CORRECT ANSWER>>>>-Direct
cholinergic agonist
-Carbon copy of
acetylcholine
-Constricts pupils and relieves intraocular pressure
in glaucoma
Methacholine - CORRECT ANSWER>>>>-Direct
cholinergic agonist
-Stimulates muscarinic receptors in airways
when inhaled
-Used as a challenge test for diagnosis
of asthma
Pilocarpine - CORRECT ANSWER>>>>-Direct cholinergic agonist
-Contracts ciliary muscle of eye (open angle glaucoma), contracts pupillary
sphincter (closed angle glaucoma)
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COMPLETE QUESTIONS WITH CORRECT
ANSWERS
What are the major functions of the M3 receptor? - CORRECT
ANSWER>>>>Increase
exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut
peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary
sphincter muscle contraction (miosis), ciliary muscle contraction
(accommodation)
What are the major functions of the D1 receptor? - CORRECT
ANSWER>>>>Relaxes renal
vascular smooth
muscle
What are the major functions of the D2 receptor? - CORRECT
ANSWER>>>>Modulates
transmitter release, especially in
the brain
Page 1 of 190
,What are the major functions of the H1 receptor? - CORRECT
ANSWER>>>>Increase nasal and bronchial mucus production, increase vascular
permeability, contraction of bronchioles, pruritis, pain
What are the major functions of the H2 receptor? - CORRECT
ANSWER>>>>Increase gastric
acid
secretion
What are the major functions of the V1 receptor? - CORRECT
ANSWER>>>>Increase vascular
smooth muscle
contraction
What are the major functions of the V2 receptor? - CORRECT
ANSWER>>>>Increase H2O
permeability and reabsorption in collecting tubules of kidney (V2 is found in
the "2" kidneys)
What are the major functions of the α1 receptor? - CORRECT
ANSWER>>>>Increase vascular smooth muscle contraction, increase pupillary
dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter
muscle contraction
What are the major functions of the α2 receptor? - CORRECT
ANSWER>>>>Decrease sympathetic outflow, decrease insulin release,
Page 2 of 190
,decrease lipolysis, increase platelet aggregation, decrease aqueous humor
production
What are the major functions of the β1 receptor? - CORRECT
ANSWER>>>>Increase heart
rate, increase contractility, increase renin release,
increase lipolysis
What are the major functions of the β2 receptor? - CORRECT
ANSWER>>>>Vasodilation,
bronchodilation, increase lipolysis, increase insulin release, decrease uterine
tone (tocolysis),
ciliary muscle relaxation, increase aqueous humor
production
What are the major functions of the M1 receptor? - CORRECT
ANSWER>>>>CNS, enteric
nervous
system
What are the major functions of the M2 receptor? - CORRECT
ANSWER>>>>Decrease heart
rate and contractility of
atria
What receptors are associate with Gq? - CORRECT ANSWER>>>>H1, α1, V1,
M1, and M3
Page 3 of 190
, What receptors are associated with Gs? - CORRECT ANSWER>>>>H2, B1, B2,
V2, D1
What receptors are associated with Gi? - CORRECT ANSWER>>>>M2, α2, D2
Bethanechol - CORRECT ANSWER>>>>-Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE
Carbachol - CORRECT ANSWER>>>>-Direct
cholinergic agonist
-Carbon copy of
acetylcholine
-Constricts pupils and relieves intraocular pressure
in glaucoma
Methacholine - CORRECT ANSWER>>>>-Direct
cholinergic agonist
-Stimulates muscarinic receptors in airways
when inhaled
-Used as a challenge test for diagnosis
of asthma
Pilocarpine - CORRECT ANSWER>>>>-Direct cholinergic agonist
-Contracts ciliary muscle of eye (open angle glaucoma), contracts pupillary
sphincter (closed angle glaucoma)
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