USMLE STEP 1
PHARMACOLOGY
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✓ This Exam contains: USMLE STEP 1 Pharmacology
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,Question 1
What are the major functions of the α1 receptor?
Correct Answer
Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase
intestinal and bladder sphincter muscle contraction
Question 2
What are the major functions of the α2 receptor?
Correct Answer
Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease
aqueous humor production
Question 3
What are the major functions of the β1 receptor?
Correct Answer
Increase heart rate, increase contractility, increase renin release, increase lipolysis
Question 4
What are the major functions of the β2 receptor?
Correct Answer
Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary
muscle relaxation, increase aqueous humor production
Question 5
What are the major functions of the M1 receptor?
Correct Answer
CNS, enteric nervous system
Question 6
What are the major functions of the M2 receptor?
Correct Answer
Decrease heart rate and contractility of atria
Question 7
What are the major functions of the M3 receptor?
Correct Answer
Increase exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder
contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction
(accommodation)
Trusted by thousands of students and professionals worldwide Page 2 of 147
,Question 8
What are the major functions of the D1 receptor?
Correct Answer
Relaxes renal vascular smooth muscle
Question 9
What are the major functions of the D2 receptor?
Correct Answer
Modulates transmitter release, especially in the brain
Question 10
What are the major functions of the H1 receptor?
Correct Answer
Increase nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis,
pain
Question 11
What are the major functions of the H2 receptor?
Correct Answer
Increase gastric acid secretion
Question 12
What are the major functions of the V1 receptor?
Correct Answer
Increase vascular smooth muscle contraction
Question 13
What are the major functions of the V2 receptor?
Correct Answer
Increase H2O permeability and reabsorption in collecting tubules of kidney (V2 is found in the "2" kidneys)
Question 14
What receptors are associate with Gq?
Correct Answer
H1, α1, V1, M1, and M3
Question 15
What receptors are associated with Gs?
Correct Answer
H2, B1, B2, V2, D1
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, Question 16
What receptors are associated with Gi?
Correct Answer
M2, α2, D2
Question 17
Bethanechol
Correct Answer
-Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE
Question 18
Carbachol
Correct Answer
-Direct cholinergic agonist
-Carbon copy of acetylcholine
-Constricts pupils and relieves intraocular pressure in glaucoma
Question 19
Methacholine
Correct Answer
-Direct cholinergic agonist
-Stimulates muscarinic receptors in airways when inhaled
-Used as a challenge test for diagnosis of asthma
Question 20
Pilocarpine
Correct Answer
-Direct cholinergic agonist
-Contracts ciliary muscle of eye (open angle glaucoma), contracts pupillary sphincter (closed angle glaucoma)
-Potent stimulator of sweat, tears and saliva
-AChE resistant
Question 21
Donepezil
Correct Answer
-Anticholinesterse - increases ACh
-Alzheimer disease
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PHARMACOLOGY
870+ (Latest 2025-2026 Edition) 100%
Verified Q&A + Answer Key Solutions
100% Guarantee Pass
✓ This Exam contains: USMLE STEP 1 Pharmacology
✓ 100% Accurate Questions and Answers
✓ 100% Guarantee Pass - Verified by Experts
✓ Each Question Includes The Correct Answer
✓ Expert-Verified
Trusted by thousands of students and professionals worldwide Page 1 of 147
,Question 1
What are the major functions of the α1 receptor?
Correct Answer
Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase
intestinal and bladder sphincter muscle contraction
Question 2
What are the major functions of the α2 receptor?
Correct Answer
Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease
aqueous humor production
Question 3
What are the major functions of the β1 receptor?
Correct Answer
Increase heart rate, increase contractility, increase renin release, increase lipolysis
Question 4
What are the major functions of the β2 receptor?
Correct Answer
Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary
muscle relaxation, increase aqueous humor production
Question 5
What are the major functions of the M1 receptor?
Correct Answer
CNS, enteric nervous system
Question 6
What are the major functions of the M2 receptor?
Correct Answer
Decrease heart rate and contractility of atria
Question 7
What are the major functions of the M3 receptor?
Correct Answer
Increase exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder
contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction
(accommodation)
Trusted by thousands of students and professionals worldwide Page 2 of 147
,Question 8
What are the major functions of the D1 receptor?
Correct Answer
Relaxes renal vascular smooth muscle
Question 9
What are the major functions of the D2 receptor?
Correct Answer
Modulates transmitter release, especially in the brain
Question 10
What are the major functions of the H1 receptor?
Correct Answer
Increase nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis,
pain
Question 11
What are the major functions of the H2 receptor?
Correct Answer
Increase gastric acid secretion
Question 12
What are the major functions of the V1 receptor?
Correct Answer
Increase vascular smooth muscle contraction
Question 13
What are the major functions of the V2 receptor?
Correct Answer
Increase H2O permeability and reabsorption in collecting tubules of kidney (V2 is found in the "2" kidneys)
Question 14
What receptors are associate with Gq?
Correct Answer
H1, α1, V1, M1, and M3
Question 15
What receptors are associated with Gs?
Correct Answer
H2, B1, B2, V2, D1
Trusted by thousands of students and professionals worldwide Page 3 of 147
, Question 16
What receptors are associated with Gi?
Correct Answer
M2, α2, D2
Question 17
Bethanechol
Correct Answer
-Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE
Question 18
Carbachol
Correct Answer
-Direct cholinergic agonist
-Carbon copy of acetylcholine
-Constricts pupils and relieves intraocular pressure in glaucoma
Question 19
Methacholine
Correct Answer
-Direct cholinergic agonist
-Stimulates muscarinic receptors in airways when inhaled
-Used as a challenge test for diagnosis of asthma
Question 20
Pilocarpine
Correct Answer
-Direct cholinergic agonist
-Contracts ciliary muscle of eye (open angle glaucoma), contracts pupillary sphincter (closed angle glaucoma)
-Potent stimulator of sweat, tears and saliva
-AChE resistant
Question 21
Donepezil
Correct Answer
-Anticholinesterse - increases ACh
-Alzheimer disease
Trusted by thousands of students and professionals worldwide Page 4 of 147
