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Biotherapy - ANSWERS-Targeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWERS-Biotherapy
Which types of agents are associated with secondary malignancies? - ANSWERS-
Alkylating agents, plant alkaloids
What are common side effects of alkylating agents? - ANSWERS-N&V, bone marrow
suppression, reproductive disabilities
What are common side effects of antitumor antibiotics? - ANSWERS-Bone marrow
suppression, mucositis, N&V, cardiac toxicity, reproductive disabilities
, Which antitumor antibiotic is cell cycle specific? - ANSWERS-Bleomycin-it works in both
G2 and M phase
What are the major side effects of antimetabolites? - ANSWERS-Bone marrow
suppression, N&V, mucositis, liver injury
What pediatric chemo drugs are antimetabolite agents? - ANSWERS-Methotrexate,
fluorouracil (5-FU), cytarabine (Ara-C),
Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea
Which antimetabolite is associated with hepatoportal sclerosis and esophageal varices?
- ANSWERS-Thioguanine
Which chemotherapy agents are hormonal agents? - ANSWERS-Corticosteroids
How do corticosteroids fight cancers? - ANSWERS-By lysing lymphoblasts, decreasing
cerebral edema associated with brain tumors, and help with antiemetic control
What are side effects of corticosteroids? - ANSWERS-Increased appetite, redistribution
of body fat, hyperglycemia, acne, striae, behavior changes, avascular necrosis.
Is asparaginase cell cycle specific or nonspecific? - ANSWERS-Nonspecific
What class of drug are interferons? - ANSWERS-Biotherapy or biological response
modifiers (BRM)
Monoclonal antibodies (MoAbs) are what class - ANSWERS-Biotherapy
Define pharmacokinetics - ANSWERS-Study of drug absorption, metabolism, and
excretion