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ONS ONCC Chemo Renewal Exam
2026|2027 - Complete Questions And
Verified Answers
full dose - correct-answer -Evidence shows that older patients with cancer can
safely obtain the same treatment benefits as younger patients when they receive
________ standard chemotherapy regimens. Many physicians are reluctant to give
full-dose chemotherapy to older adults perhaps due to of fear of adverse events
like febrile neutropenia. Suboptimal dosing from increasing the length of time
between cycles or from dose reduction is a serious issue because large,
randomized clinical trials have demonstrated that the delivery of lower doses or
shorter courses of chemotherapy can reduce overall survival in older patients with
breast cancer or lymphoma
85% - correct-answer -Amgen (2007) defines RDI as "is a quantification of how
closely an administered course of chemotherapy treatment adheres to a specific
regimen." Three separate clinical trials evaluating outcomes in patients with
breast cancer related to RDI have demonstrated improved overall survival and 10-
year disease free survival in patients who receive a RDI > or = ____?_____
Per the prescribing information for Perjeta
(http://www.gene.com/download/pdf/perjeta_prescribing.pdf) it states to assess
, 2
LVEF prior to initiation of PERJETA and at regular intervals (every six weeks in the
neoadjuvant setting) during treatment to ensure that LVEF is within the
institution's normal limits. Mrs. Turner's chemotherapy is given every 3 weeks so
she should have her LVEF evaluated prior to cycle #3. If Mrs. Turner was receiving
trastuzumab without pertuzumab, the recommendation per the prescribing
information for Herceptin
(http://www.gene.com/download/pdf/herceptin_prescribing.pdf) is to monitor
baseline LVEF measurement immediately prior to initiation of Herceptin and
monitor LVEF every 3 months during and upon completion of Herceptin. - correct-
answer -You know the reason that Mrs. Turner had another MUGA scan prior to
receiving her 3rd cycle of neoadjuvant chemotherapy is because it is
recommended for which of the following agents?
Mrs. Turner's initial MUGA scan result was 55% and is now decreased to 48%
which is a > 10% decrease in her LVEF. Per the prescribing information for Perjeta,
if the LVEF is 45%, or is 45% to 49% with a 10% or greater absolute decrease
below the pretreatment value, withhold PERJETA and trastuzumab and repeat
LVEF assessment within approximately 3 weeks
(http://www.gene.com/download/pdf/perjeta_prescribing.pdf). You should call
the doctor to provide the results of the MUGA scan compared to her initial MUGA
scan and anticipate that the trastuzumab and pertuzumab will be held for this
cycle of chemotherapy. Mrs. Turner should have a repeat MUGA scan prior to
cycle #4 and based on those results, discontinue PERJETA and trastuzumab if the
LVEF has not improved or has declined further, unless the benefits for the
individual patient outweigh the risks. - correct-answer -You realize that since Mrs.
Turner is on a regimen that includes pertuzumab that she should have her LVEF
monitored every 6 weeks since she is receiving neoadjuvant therapy. You review
Mrs. Turner's most recent MUGA scan and see that her LVEF is 48%.
, 3
heart function - correct-answer -Two of the agents in the patients currecnt
regimen, trastuzumab and pertuzumab, have the potential to cause a decline in
_____________
8.4% - correct-answer -It is important that the nurse recognizes certain drugs that,
when given together, may result in a higher risk of adverse events. For example, in
neoadjuvant clinical trials using trastuzumab and pertuzumab, the incidence of
decline in left ventricular ejection fraction (LVEF) was 1.9% in patients treated with
trastuzumab and docetaxel, compared to ______ of those treated with
trastuzumab, docetaxel, and pertuzumab (Genentech, 2013).
Consider the potential toxicity related to each drug.
Understand the monitoring guidelines for each drug.
Have knowledge of clinically significant signs and symptoms. - correct-answer -Key
Points for Combination Therapy
Improved patient outcomes.
Increased nurse satisfaction.
Potential cost savings. - correct-answer -Evidence-based practice can have positive
effects, such as:
ONS ONCC Chemo Renewal Exam
2026|2027 - Complete Questions And
Verified Answers
full dose - correct-answer -Evidence shows that older patients with cancer can
safely obtain the same treatment benefits as younger patients when they receive
________ standard chemotherapy regimens. Many physicians are reluctant to give
full-dose chemotherapy to older adults perhaps due to of fear of adverse events
like febrile neutropenia. Suboptimal dosing from increasing the length of time
between cycles or from dose reduction is a serious issue because large,
randomized clinical trials have demonstrated that the delivery of lower doses or
shorter courses of chemotherapy can reduce overall survival in older patients with
breast cancer or lymphoma
85% - correct-answer -Amgen (2007) defines RDI as "is a quantification of how
closely an administered course of chemotherapy treatment adheres to a specific
regimen." Three separate clinical trials evaluating outcomes in patients with
breast cancer related to RDI have demonstrated improved overall survival and 10-
year disease free survival in patients who receive a RDI > or = ____?_____
Per the prescribing information for Perjeta
(http://www.gene.com/download/pdf/perjeta_prescribing.pdf) it states to assess
, 2
LVEF prior to initiation of PERJETA and at regular intervals (every six weeks in the
neoadjuvant setting) during treatment to ensure that LVEF is within the
institution's normal limits. Mrs. Turner's chemotherapy is given every 3 weeks so
she should have her LVEF evaluated prior to cycle #3. If Mrs. Turner was receiving
trastuzumab without pertuzumab, the recommendation per the prescribing
information for Herceptin
(http://www.gene.com/download/pdf/herceptin_prescribing.pdf) is to monitor
baseline LVEF measurement immediately prior to initiation of Herceptin and
monitor LVEF every 3 months during and upon completion of Herceptin. - correct-
answer -You know the reason that Mrs. Turner had another MUGA scan prior to
receiving her 3rd cycle of neoadjuvant chemotherapy is because it is
recommended for which of the following agents?
Mrs. Turner's initial MUGA scan result was 55% and is now decreased to 48%
which is a > 10% decrease in her LVEF. Per the prescribing information for Perjeta,
if the LVEF is 45%, or is 45% to 49% with a 10% or greater absolute decrease
below the pretreatment value, withhold PERJETA and trastuzumab and repeat
LVEF assessment within approximately 3 weeks
(http://www.gene.com/download/pdf/perjeta_prescribing.pdf). You should call
the doctor to provide the results of the MUGA scan compared to her initial MUGA
scan and anticipate that the trastuzumab and pertuzumab will be held for this
cycle of chemotherapy. Mrs. Turner should have a repeat MUGA scan prior to
cycle #4 and based on those results, discontinue PERJETA and trastuzumab if the
LVEF has not improved or has declined further, unless the benefits for the
individual patient outweigh the risks. - correct-answer -You realize that since Mrs.
Turner is on a regimen that includes pertuzumab that she should have her LVEF
monitored every 6 weeks since she is receiving neoadjuvant therapy. You review
Mrs. Turner's most recent MUGA scan and see that her LVEF is 48%.
, 3
heart function - correct-answer -Two of the agents in the patients currecnt
regimen, trastuzumab and pertuzumab, have the potential to cause a decline in
_____________
8.4% - correct-answer -It is important that the nurse recognizes certain drugs that,
when given together, may result in a higher risk of adverse events. For example, in
neoadjuvant clinical trials using trastuzumab and pertuzumab, the incidence of
decline in left ventricular ejection fraction (LVEF) was 1.9% in patients treated with
trastuzumab and docetaxel, compared to ______ of those treated with
trastuzumab, docetaxel, and pertuzumab (Genentech, 2013).
Consider the potential toxicity related to each drug.
Understand the monitoring guidelines for each drug.
Have knowledge of clinically significant signs and symptoms. - correct-answer -Key
Points for Combination Therapy
Improved patient outcomes.
Increased nurse satisfaction.
Potential cost savings. - correct-answer -Evidence-based practice can have positive
effects, such as:
