Incidence
Imperforate Anus Occurs in approximately 1 in
4,000–5,000 live births
(Anorectal
Slightly more common in
Malformation) –
males
Brief Overview Often associated with other
congenital anomalies
(especially VACTERL
association)
Causes (Etiology)
Clinical Features
Due to abnormal development of the
At birth:Absence of visible anal opening
hindgut during embryogenesis
Failure to pass meconium within 24–48 hours
Failure of proper cloacal partitioning
Abdominal signs:Progressive abdominal
by the urorectal septum distension
Results in: Vomiting (may become bilious)
Absence of anal opening →
Fistula-related signs:Meconium in urine
Abnormal fistulous connections recto-urethral/vesical fistula
(to urethra, bladder, or vagina) →
Meconium in vagina rectovaginal fistula
Imperforate Anus Occurs in approximately 1 in
4,000–5,000 live births
(Anorectal
Slightly more common in
Malformation) –
males
Brief Overview Often associated with other
congenital anomalies
(especially VACTERL
association)
Causes (Etiology)
Clinical Features
Due to abnormal development of the
At birth:Absence of visible anal opening
hindgut during embryogenesis
Failure to pass meconium within 24–48 hours
Failure of proper cloacal partitioning
Abdominal signs:Progressive abdominal
by the urorectal septum distension
Results in: Vomiting (may become bilious)
Absence of anal opening →
Fistula-related signs:Meconium in urine
Abnormal fistulous connections recto-urethral/vesical fistula
(to urethra, bladder, or vagina) →
Meconium in vagina rectovaginal fistula
