S.P., a 65y.o. female presented to the ED with complaints of headache, nausea, vomiting, and chest
discomfort. The patient reports not taking her medications prior to coming to the ED. Her
antihypertensive were administered in the ED. She was admitted to the telemetry floor with the
diagnosis of “Rule out MI and hypertension.”
Past Medical History
1. DM type 2
2. HTN
3. GERD
Medication’s:
Glipizide 5mg daily p.o
Lisinopril 5mg daily p.o
Protonix 40mg daily p.o
Admission Vitals and labs
Vital Signs
B/P 190/105 mmHg
HR 72 bpm
Respirations 20 breaths/min
Temperature 38.6 degrees
Complete Blood Count
Hgb 12.1 g/dL
Hct 36%
RBC’s 4.5 x 106
WBC’s 7,000/mm3
Cardiac Enzymes
Troponin <0.01 ng/mL
CK 170 U/L
CK-MB 1.2 ng/mL
Myoglobin 56ng/mL
BNP 65 pg/mL
Electrolyte Panel
Na+ 135 mmol/L
K+ 4.8 mmol/L
, Cl- 100 mmol/L
Ca++ 8.5 mg/dL
Creatinine 0.7 mg/dL
Laboratory results and vital signs were telephoned to her physician. Her physician order’s included the
following:
1. Resume home medications- Lisinopril, Glipizide, and Protonix
2. Start Aspirin 325mg p.o, Plavix 75 mg p.o, heparin 5,000 units subcu. every 8 hours, and Toprol
XL 100mg p.o BID hold if systolic BP < 90 or diastolic pressure of < 60 and HR <60.
3. PRN medications: give NTG 0.4 mg sublingual x3 for CP, Diltiazem 10 mg IV PRN for SBP of >160
every 4 hours.
4. Cardiac enzymes and EKG q 6 hours x3
5. Vital signs q 4 hours
6. Repeat vital signs in 1 hour
Repeat vital signs are taken:
Vital Signs
B/P 220/115 mmHg
HR 72 bpm
Respirations 20 breaths/min
Temperature 38.6 degrees
The patient complaints of a worsened headache.
You call the physician with the S.P.’s vital signs and assessment findings.
The physician diagnoses that S.P. is in Hypertensive Urgency. The patients is transferred to the ICU with
orders to begin a Nitroglycerin gtt at 5mcg/min. The order is to titrate to a goal blood pressure of 160/90
in the first hour.
1. What is the mechanism of action of Nitroglycerin? How does it treat
hypertension/hypertensive urgencies?
2. Why did the physician choose to only lower the blood pressure to 160/90? What would
happen if the blood pressure would be lowered to “normal” within the first hour? What
organs are at highest risk of being affected by too rapid of a change in blood pressure?