MMSC 433 EXAM QUESTIONS AND
ANSWERS 100% PASS 2026/2027
A "dry tap" bone marrow aspiration may be seen with what chronic myeloid proliferative
disease?
A: essential thrombocythemia
B: polycythemia vera
C: primary myelofibrosis
D: Chronic myeloid leukemia - ANS Primary myelofibrosis
what clinical feature is more often associated with essential thrombocythemia than with the
other chronic myeloproliferative disorders?
A: bleeding and thrombosis
B: infections
C: splenomegaly
D: fatigue - ANS bleeding and thromboses
what is the most common chromosomal abnormality in polycythemia vera (PV)?
@2026 ALLRIGHTS RESERVED 1
,A: BCR-ABL
B: PML-RARA
C: TET-2
D: JAK2V617F - ANS JAK2V617F
which of the following is an expected finding in polycythemia vera?
A: normal white cell count
B: anemia
C: increased RBC mass
D: low leukocyte alkaline phosphatase - ANS increased RBC mass
a patient has a normal white cell count, a moderately high platelet count, and mild anemia. The
differential shows immature granulocytes, nucleated red cells, and teardrop-shaped red cells.
Which of the following is most likely?
A: chronic myelogenous leukoemia
B: primary myelofibrosis
C: polycythemia vera
D: essential thrombocythemia - ANS primary myelofibrosis
a patient has a platelet count of 1200*10⁹/L. Many platelets are giant and have abnormal
shapes. A mild anemia is present. The bone marrow has increased megakaryocytes in clusters;
iron stores are present. Which of the following is most likely?
A: chronic myelogenous leukemia
B: polycythemia vera
@2026 ALLRIGHTS RESERVED 2
, C: thrombosis secondary to blood loss
D: essential thrombocythemia - ANS essential thrombocythemia
which one of the following chromosome abnormalities is associated with CML?
A: t(8;14)
B: trisomy 18
C: t(15;17)
D: t(9;22) - ANS t(9;22)
all of the following are minor criteria for overt PMF, except:
A: WBC count < 10*10⁹/L
B: palpable splenomegaly
C: leukoerythroblastosis
D: leukocytosis ≥ 11*10⁹/L - ANS WBC count < 10*10⁹/L
what is the treatment for Polycythemia Vera (PV)?
A: therapeutic phlebotomy
B: ruxolitinib (inhibitor of JAK2)
C: hydroxyurea
D: all answers are correct - ANS all answers are correct
hematopoietic stem cell transplantation is accepted as a cure for MDS
@2026 ALLRIGHTS RESERVED 3
ANSWERS 100% PASS 2026/2027
A "dry tap" bone marrow aspiration may be seen with what chronic myeloid proliferative
disease?
A: essential thrombocythemia
B: polycythemia vera
C: primary myelofibrosis
D: Chronic myeloid leukemia - ANS Primary myelofibrosis
what clinical feature is more often associated with essential thrombocythemia than with the
other chronic myeloproliferative disorders?
A: bleeding and thrombosis
B: infections
C: splenomegaly
D: fatigue - ANS bleeding and thromboses
what is the most common chromosomal abnormality in polycythemia vera (PV)?
@2026 ALLRIGHTS RESERVED 1
,A: BCR-ABL
B: PML-RARA
C: TET-2
D: JAK2V617F - ANS JAK2V617F
which of the following is an expected finding in polycythemia vera?
A: normal white cell count
B: anemia
C: increased RBC mass
D: low leukocyte alkaline phosphatase - ANS increased RBC mass
a patient has a normal white cell count, a moderately high platelet count, and mild anemia. The
differential shows immature granulocytes, nucleated red cells, and teardrop-shaped red cells.
Which of the following is most likely?
A: chronic myelogenous leukoemia
B: primary myelofibrosis
C: polycythemia vera
D: essential thrombocythemia - ANS primary myelofibrosis
a patient has a platelet count of 1200*10⁹/L. Many platelets are giant and have abnormal
shapes. A mild anemia is present. The bone marrow has increased megakaryocytes in clusters;
iron stores are present. Which of the following is most likely?
A: chronic myelogenous leukemia
B: polycythemia vera
@2026 ALLRIGHTS RESERVED 2
, C: thrombosis secondary to blood loss
D: essential thrombocythemia - ANS essential thrombocythemia
which one of the following chromosome abnormalities is associated with CML?
A: t(8;14)
B: trisomy 18
C: t(15;17)
D: t(9;22) - ANS t(9;22)
all of the following are minor criteria for overt PMF, except:
A: WBC count < 10*10⁹/L
B: palpable splenomegaly
C: leukoerythroblastosis
D: leukocytosis ≥ 11*10⁹/L - ANS WBC count < 10*10⁹/L
what is the treatment for Polycythemia Vera (PV)?
A: therapeutic phlebotomy
B: ruxolitinib (inhibitor of JAK2)
C: hydroxyurea
D: all answers are correct - ANS all answers are correct
hematopoietic stem cell transplantation is accepted as a cure for MDS
@2026 ALLRIGHTS RESERVED 3
