Page 1 of 102
COMSAE 114 LATEST EXAM QUESTIONS AND CORRECT
VERIFIED SOLUTIONS LATEST UPDATE THIS YEAR – JUST
RELEASED
EXAM COVERAGE – COMSAE 114
This exam commonly emphasizes:
1. Osteopathic principles and manipulative medicine
2. Foundational biomedical sciences or clinical sciences (depending on Phase 1 vs 2)
3. Diagnosis and next-best-step reasoning
4. Common board-style pathologies and management
5. Ethics, communication, and patient safety
6. High-yield systems review: cardio, pulm, neuro, renal, GI, endocrine, MSK, repro
7. Time management and test endurance
1. A 22-year-old medical student has fever, fatigue, posterior cervical lymphadenopathy, and
splenomegaly. Which finding is most likely on peripheral smear?
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A. Schistocytes
B. Smudge cells
C. Atypical lymphocytes
D. Hypersegmented neutrophils
Answer: C
Rationale: This is classic infectious mononucleosis due to EBV. The hallmark is atypical reactive
CD8+ lymphocytes on smear.
2. A patient with somatic dysfunction has a left-on-left sacral torsion. Which sacral axis is
involved?
A. Right oblique axis
B. Left oblique axis
C. Superior transverse axis
D. Inferior transverse axis
Answer: B
Rationale: In sacral torsions, the first word is the side of rotation and the second word is the
oblique axis. Left-on-left = left oblique axis.
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3. A 64-year-old man presents with crushing substernal chest pain radiating to the left arm.
Which coronary artery most commonly supplies the SA node?
A. Left anterior descending artery
B. Right coronary artery
C. Left circumflex artery
D. Posterior descending artery
Answer: B
Rationale: In most people, the right coronary artery supplies the SA node and is frequently
tested in cardiac anatomy.
4. A child has recurrent Neisseria infections. Which immune deficiency is most likely present?
A. C5–C9 deficiency
B. IL-2 deficiency
C. IgA deficiency
D. Bruton's agammaglobulinemia
Answer: A
Rationale: Terminal complement deficiency (C5–C9) causes impaired MAC formation and
predisposes to Neisseria infections.
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5. A patient with diabetes has decreased vibration and proprioception in both feet. Which
spinal tract is affected?
A. Spinothalamic tract
B. Dorsal columns
C. Corticospinal tract
D. Rubrospinal tract
Answer: B
Rationale: Vibration and proprioception are carried by the dorsal columns, often impaired in
diabetic neuropathy or B12 deficiency.
6. A patient with asthma receives albuterol. Which receptor mediates bronchodilation?
A. Alpha-1
B. Beta-1
C. Beta-2
D. Muscarinic M3
Answer: C
Rationale: Albuterol is a beta-2 agonist, which relaxes bronchial smooth muscle and causes
bronchodilation.
COMSAE 114 LATEST EXAM QUESTIONS AND CORRECT
VERIFIED SOLUTIONS LATEST UPDATE THIS YEAR – JUST
RELEASED
EXAM COVERAGE – COMSAE 114
This exam commonly emphasizes:
1. Osteopathic principles and manipulative medicine
2. Foundational biomedical sciences or clinical sciences (depending on Phase 1 vs 2)
3. Diagnosis and next-best-step reasoning
4. Common board-style pathologies and management
5. Ethics, communication, and patient safety
6. High-yield systems review: cardio, pulm, neuro, renal, GI, endocrine, MSK, repro
7. Time management and test endurance
1. A 22-year-old medical student has fever, fatigue, posterior cervical lymphadenopathy, and
splenomegaly. Which finding is most likely on peripheral smear?
, Page 2 of 102
A. Schistocytes
B. Smudge cells
C. Atypical lymphocytes
D. Hypersegmented neutrophils
Answer: C
Rationale: This is classic infectious mononucleosis due to EBV. The hallmark is atypical reactive
CD8+ lymphocytes on smear.
2. A patient with somatic dysfunction has a left-on-left sacral torsion. Which sacral axis is
involved?
A. Right oblique axis
B. Left oblique axis
C. Superior transverse axis
D. Inferior transverse axis
Answer: B
Rationale: In sacral torsions, the first word is the side of rotation and the second word is the
oblique axis. Left-on-left = left oblique axis.
, Page 3 of 102
3. A 64-year-old man presents with crushing substernal chest pain radiating to the left arm.
Which coronary artery most commonly supplies the SA node?
A. Left anterior descending artery
B. Right coronary artery
C. Left circumflex artery
D. Posterior descending artery
Answer: B
Rationale: In most people, the right coronary artery supplies the SA node and is frequently
tested in cardiac anatomy.
4. A child has recurrent Neisseria infections. Which immune deficiency is most likely present?
A. C5–C9 deficiency
B. IL-2 deficiency
C. IgA deficiency
D. Bruton's agammaglobulinemia
Answer: A
Rationale: Terminal complement deficiency (C5–C9) causes impaired MAC formation and
predisposes to Neisseria infections.
, Page 4 of 102
5. A patient with diabetes has decreased vibration and proprioception in both feet. Which
spinal tract is affected?
A. Spinothalamic tract
B. Dorsal columns
C. Corticospinal tract
D. Rubrospinal tract
Answer: B
Rationale: Vibration and proprioception are carried by the dorsal columns, often impaired in
diabetic neuropathy or B12 deficiency.
6. A patient with asthma receives albuterol. Which receptor mediates bronchodilation?
A. Alpha-1
B. Beta-1
C. Beta-2
D. Muscarinic M3
Answer: C
Rationale: Albuterol is a beta-2 agonist, which relaxes bronchial smooth muscle and causes
bronchodilation.
