NUR 338 EXAM 2 QUESTIONS AND
ALL CORRECT ANSWERS 2025-2026
EDITION.
Direct thrombin inhibitors - Answer Lepirudin
What is Lepirudin used for? - Answer HITT (counteracts thrombin free and bound in clot) and
ACS
A nurse accidentally gave 0.80 mg of lepirudin instead of 0.08 mg. What will be the nurses next
step? - Answer Call the provider immediately because there is no known antagonist to
reverse effects.
What drug-drug interactions occur with lepirudin/urokinase that causes a higher risk of
bleeding? - Answer Anticoagulant and antiplatelet
What labs should you monitor with lepirudin? - Answer PTT and LFT due to hepatic injury
Thrombolytics - Answer urokinase and streptokinase
Urokinase changes plasminogen to - Answer plasmin
Urokinase is used in life threatening situations like? - Answer Stroke, DVT, PE, MI
A female client has come into the hospital with a stroke. The doctor orders UROKINASE to be
given. What should the nurse ask before giving it? - Answer "Are you pregnant?" or "Is the
client pregnant?" due to the risk of miscarriage
Trauma is CI in urokinase for? - Answer The risk of hemmorrhaging
The risk for stroke from urokinase is CI in patient with... - Answer Uncontrolled HTN
The biggest adverse effects of any thrombolytic and direct thrombin inhibitor. - Answer
BLEEDING
A patient was just admitted to the hospital suffering a MI. The nurse administers urokinase.
What would be most alarming to the nurse?
, a. RR 14
b. HR 30
c. BP 120/70 - Answer b. HR 30; there is a risk of an adverse effect of dysrhythmias for MI
patients because you are quickly bringing blood into the heart which can cause an arrhythmia.
*Perform EKG and place on telemetry*
Will a patient have hypo- or hyper- tension if they are bleeding? - Answer Hypotension
Streptokinase MOA - Answer binds to plasminogen leading to plasmin formation
S/S of allergic rxns
SOB
Fever
HR increase
BP decrease
Flushing - Answer Streptokinase has a common reaction of an allergic reaction.
Alteplase is used for - Answer ischemic stroke
Streptokinase, alteplase, tPA must be given within a certain time frame for - Answer It can
cause further complications so it is important to know when the stroke, MI, etc. began.
A patient has Hemophilia A and the doctor has ordered antihemophilic agents as a part of their
new care. What should the nurse first screen for? - Answer Allergies to mouse proteins
AE of antihemophilics - Answer blood tranfusion reactions symptoms, hepatitis, and AIDS
Patient education of antihemophilics - Answer NO contact sports
Wear gardening gloves
Avoid injuries
S/S of bleeding
Why is pregnancy cautioned with antihemophilics? - Answer Risk of venous
thromboembolism and should be avoid with lactation
Hemostatic PT - Answer aminocaproic acid
ALL CORRECT ANSWERS 2025-2026
EDITION.
Direct thrombin inhibitors - Answer Lepirudin
What is Lepirudin used for? - Answer HITT (counteracts thrombin free and bound in clot) and
ACS
A nurse accidentally gave 0.80 mg of lepirudin instead of 0.08 mg. What will be the nurses next
step? - Answer Call the provider immediately because there is no known antagonist to
reverse effects.
What drug-drug interactions occur with lepirudin/urokinase that causes a higher risk of
bleeding? - Answer Anticoagulant and antiplatelet
What labs should you monitor with lepirudin? - Answer PTT and LFT due to hepatic injury
Thrombolytics - Answer urokinase and streptokinase
Urokinase changes plasminogen to - Answer plasmin
Urokinase is used in life threatening situations like? - Answer Stroke, DVT, PE, MI
A female client has come into the hospital with a stroke. The doctor orders UROKINASE to be
given. What should the nurse ask before giving it? - Answer "Are you pregnant?" or "Is the
client pregnant?" due to the risk of miscarriage
Trauma is CI in urokinase for? - Answer The risk of hemmorrhaging
The risk for stroke from urokinase is CI in patient with... - Answer Uncontrolled HTN
The biggest adverse effects of any thrombolytic and direct thrombin inhibitor. - Answer
BLEEDING
A patient was just admitted to the hospital suffering a MI. The nurse administers urokinase.
What would be most alarming to the nurse?
, a. RR 14
b. HR 30
c. BP 120/70 - Answer b. HR 30; there is a risk of an adverse effect of dysrhythmias for MI
patients because you are quickly bringing blood into the heart which can cause an arrhythmia.
*Perform EKG and place on telemetry*
Will a patient have hypo- or hyper- tension if they are bleeding? - Answer Hypotension
Streptokinase MOA - Answer binds to plasminogen leading to plasmin formation
S/S of allergic rxns
SOB
Fever
HR increase
BP decrease
Flushing - Answer Streptokinase has a common reaction of an allergic reaction.
Alteplase is used for - Answer ischemic stroke
Streptokinase, alteplase, tPA must be given within a certain time frame for - Answer It can
cause further complications so it is important to know when the stroke, MI, etc. began.
A patient has Hemophilia A and the doctor has ordered antihemophilic agents as a part of their
new care. What should the nurse first screen for? - Answer Allergies to mouse proteins
AE of antihemophilics - Answer blood tranfusion reactions symptoms, hepatitis, and AIDS
Patient education of antihemophilics - Answer NO contact sports
Wear gardening gloves
Avoid injuries
S/S of bleeding
Why is pregnancy cautioned with antihemophilics? - Answer Risk of venous
thromboembolism and should be avoid with lactation
Hemostatic PT - Answer aminocaproic acid
