Week 6 Sherpath:
Immunosuppressant/Immunomodulat
or Therapy Final Exam and All Actual
Answers.
Which drug classes are used in the management of rheumatoid arthritis (RA)?
Select all that apply.
A. Biologic disease-modifying antirheumatic drugs (DMARDs)
B. Glucocorticoids
C. Mineralocorticoids
D. Nonbiologic DMARDs
E. Nonsteroidal anti-inflammatory drugs (NSAIDs) - Answer A, B, D and E
Biologic disease-modifying antirheumatic drugs (DMARDs)
Biologic DMARDs represent a large, diverse class of DMARDs that work to slow disease
progression. They are individually designed to target different areas of the immune system.
Glucocorticoids
Glucocorticoids are useful in RA to provide rapid relief of pain and inflammation. They also slow
the disease process but are associated with serious adverse effects when taken chronically.
Nonbiologic DMARDs
Nonbiologic DMARDs, or traditional DMARDs, are recommended to be initiated within 3
months of diagnosis to slow disease progression. They include methotrexate, leflunomide,
hydroxychloroquine, sulfasalazine, tofacitinib, and baricitinib.
Nonsteroidal antiinflammatory drugs (NSAIDs)
NSAIDs provide relief from pain and inflammation but have no effect on disease progression.
Which disease-modifying antirheumatic drugs (DMARDs) are considered nonbiologic?
Select all that apply.
A. Anakinra
B. Abatacept
C. Etanercept
D. Tocilizumab
, E. Methotrexate
F. Hydroxychloroquine - Answer E and F
Methotrexate
Methotrexate is a nonbiologic DMARD.
Hydroxychloroquine
Hydroxychloroquine is a nonbiologic DMARD.
Which disease-modifying antirheumatic drug (DMARD) is highly protein bound (99%)?
A. Abatacept
B. Leflunomide
C. Methotrexate
D. Tofacitinib - Answer B. Leflunomide
Leflunomide is a highly protein-bound drug, with an estimated protein binding of 99%.
Which time frame accurately describes methotrexate's onset of action?
A. 0.5 to 1 hour
B. 1 to 2 hours
C. 3 to 10 hours
D. 3 to 6 weeks - Answer D. 3 to 6 weeks
Methotrexate has a delayed onset of action of 3 to 6 weeks.
Which teaching point would a nurse share with Ms. Harrison as she begins therapy with
etanercept?
A. She should inject the etanercept into the same site daily.
B. She should inject the etanercept into the upper arm or buttocks.
C. She should notice improvements in her symptoms within 1 to 2 days of starting etanercept.
D. She should contact her health care provider if she has a fever of 100.5°F (38.1°C) or higher,
nausea, vomiting, or sore throat because infection may occur with etanercept. - Answer D.
She should contact her health care provider if she has a fever of 100.5°F (38.1°C) or higher,
nausea, vomiting, or sore throat because infection may occur with etanercept.
Biologic DMARDs are associated with an increased risk of infection. Therefore fever, nausea,
vomiting, and sore throat might indicate infection and should be reported immediately.
A nurse is caring for a patient diagnosed with rheumatoid arthritis (RA) who has been
prescribed etanercept 50 mg subcutaneously each week. Before the patient begins etanercept,
which baseline parameters would be assessed?
Immunosuppressant/Immunomodulat
or Therapy Final Exam and All Actual
Answers.
Which drug classes are used in the management of rheumatoid arthritis (RA)?
Select all that apply.
A. Biologic disease-modifying antirheumatic drugs (DMARDs)
B. Glucocorticoids
C. Mineralocorticoids
D. Nonbiologic DMARDs
E. Nonsteroidal anti-inflammatory drugs (NSAIDs) - Answer A, B, D and E
Biologic disease-modifying antirheumatic drugs (DMARDs)
Biologic DMARDs represent a large, diverse class of DMARDs that work to slow disease
progression. They are individually designed to target different areas of the immune system.
Glucocorticoids
Glucocorticoids are useful in RA to provide rapid relief of pain and inflammation. They also slow
the disease process but are associated with serious adverse effects when taken chronically.
Nonbiologic DMARDs
Nonbiologic DMARDs, or traditional DMARDs, are recommended to be initiated within 3
months of diagnosis to slow disease progression. They include methotrexate, leflunomide,
hydroxychloroquine, sulfasalazine, tofacitinib, and baricitinib.
Nonsteroidal antiinflammatory drugs (NSAIDs)
NSAIDs provide relief from pain and inflammation but have no effect on disease progression.
Which disease-modifying antirheumatic drugs (DMARDs) are considered nonbiologic?
Select all that apply.
A. Anakinra
B. Abatacept
C. Etanercept
D. Tocilizumab
, E. Methotrexate
F. Hydroxychloroquine - Answer E and F
Methotrexate
Methotrexate is a nonbiologic DMARD.
Hydroxychloroquine
Hydroxychloroquine is a nonbiologic DMARD.
Which disease-modifying antirheumatic drug (DMARD) is highly protein bound (99%)?
A. Abatacept
B. Leflunomide
C. Methotrexate
D. Tofacitinib - Answer B. Leflunomide
Leflunomide is a highly protein-bound drug, with an estimated protein binding of 99%.
Which time frame accurately describes methotrexate's onset of action?
A. 0.5 to 1 hour
B. 1 to 2 hours
C. 3 to 10 hours
D. 3 to 6 weeks - Answer D. 3 to 6 weeks
Methotrexate has a delayed onset of action of 3 to 6 weeks.
Which teaching point would a nurse share with Ms. Harrison as she begins therapy with
etanercept?
A. She should inject the etanercept into the same site daily.
B. She should inject the etanercept into the upper arm or buttocks.
C. She should notice improvements in her symptoms within 1 to 2 days of starting etanercept.
D. She should contact her health care provider if she has a fever of 100.5°F (38.1°C) or higher,
nausea, vomiting, or sore throat because infection may occur with etanercept. - Answer D.
She should contact her health care provider if she has a fever of 100.5°F (38.1°C) or higher,
nausea, vomiting, or sore throat because infection may occur with etanercept.
Biologic DMARDs are associated with an increased risk of infection. Therefore fever, nausea,
vomiting, and sore throat might indicate infection and should be reported immediately.
A nurse is caring for a patient diagnosed with rheumatoid arthritis (RA) who has been
prescribed etanercept 50 mg subcutaneously each week. Before the patient begins etanercept,
which baseline parameters would be assessed?
