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NBME Subject Tests: Complete Questions with Verified Answers | USMLE Step 1 & Step 2 Study Guide

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Master the NBME subject tests with this comprehensive question bank featuring verified answers and detailed explanations. Covers all essential medical topics for USMLE Step 1 and Step 2 including microbiology (Candida albicans, Cryptococcus, Nocardia, Legionella, Vibrio vulnificus, Herpes simplex virus, Streptococcus pneumoniae, Chlamydia trachomatis), pharmacology (drug mechanisms, aspirin toxicity, heparin-induced thrombocytopenia, statin MOA, ACE inhibitors, lithium monitoring), pathology (cancer genetics, hemodialysis complications, transplant rejection, sickle cell disease, hemochromatosis, amyloidosis), physiology (acid-base balance, fluid and electrolyte disorders, cardiac output calculations, renal physiology), biochemistry (DNA replication enzymes, protein synthesis, metabolic pathways, vitamin deficiencies), clinical medicine (stroke syndromes, myocardial infarction, heart failure, COPD, asthma, diabetes, hypertension, Cushing syndrome, Addison disease), and epidemiology (study designs, biostatistics, sensitivity, specificity, PPV, NPV). Essential for medical students preparing for NBME shelf exams, USMLE Step 1, and USMLE Step 2 CK.

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NBME SUBJECT TESTS QUESTIONS WITH
VERIFIED ANSWERS | ALREADY GRADED
A+ | 2026/2027 LATEST EXAM


7 0-yoF found to have persistent fever despite IV broad-spectrum ABX therapy
3 days after undergoing operative excision of the anterior pelvic organs for
recurrent cervical carcinoma. Temp: 38.5°C (101.3°F). Physical exam:presence
of a central venous catheter that was placed on the day of the operation. There is
also a well- healing abdominal wound without erythema and with two drains in
place. Blood cultures and cultures of the tip of the central catheter on a sheep
blood agar plate grow the organism shown in the photograph. A Gram stain of
one of the colonies shows 4-μm, elliptical, purple, budding organisms. Which of
the following is the most likely causal organism?

A-Candida albicans

B-Cryptococcus neoformans

C- Escherichia coli

D- Sporothrix schenckii

E- Staphylococcus aureus - CORRECT ANSWER>>>>A-Candida albicans

man comes to the physician for a follow up exam. Two weeks ago, he was
discharged from the hosp after sustaining MI. He smokes 2 packs of cigarettes
and drinks 4 12 oz beer daily. His diet mostly consists of cured meats and fast
food. He does not exercise. pt. tells the physician, "I know that I need to make


1

,some changes in how I live so that my heart can be healthier. I just don't have
the willpower to quit smoking and drinking and all that stuff right now." Which
of the following best describes this patient's stage of behavioural change?

Precontemplation, Contemplation, Preparration, Action, Maintenance -
CORRECT ANSWER>>>>Contemplation-acknowledging that there is a
problem, but not yet ready or willing to make a change

[precontemplation-not yet acknowledging that there is a problem

A 6-week-old boy is brought to the physician for a follow-up examination after
newborn hemoglobin electrophoresis showed homozygosity for hemoglobin S.
Daily treatment with penicillin is recommended. This treatment will most likely
decrease this patient's risk for infection with which of the following organisms?

A ) Escherichia coli

B ) Haemophilus influenzae

C ) Neisseria meningitidis

D ) Salmonella species

E ) Streptococcus pneumoniae - CORRECT ANSWER>>>>E )
Streptococcus pneumoniae

7 8 yr old man fever, chills, fatigue, shortness of breath, 12 lb weight loss over
past month. Underwent urinary catheterization 6 wk ago for prostatic
obstruction. Temperature is 101.3F, pulse is 100/min, respirations are 14/min,
and bp is 1 60/80mmhg. Soft sa and normal s2 . Grade 2/6 diastolic murmur is
maximal in second left intercostal space accentuated when patient leans forward
with held expiration. Diagnosis?

bacterial endocarditis

peritonitis prostatitis

2

,PE viral pneumonia - CORRECT ANSWER>>>>bacterial endocarditis

3 2 year old woman, gravida 4, para 0, aborta 3, delivers a female newborn at
term with dysmorphic features and numerous organ anomalies. mother has had
multiple spontaneous abortions , and this is her first live newborn child. most
likely explanation for the abnormalities seen in this newborn?

A) Autosomal dominant inheritance

B) Autosomal recessive inheritance

C) Gonadal mosaicism

D) Submicroscopic deletion

E) Unbalanced chromosome rearrangement - CORRECT ANSWER>>>>E)
Unbalanced chromosome rearrangement




2 6-month-old boy with SOB & cough who had cutaneous abscesses caused by
S.

aureus. febrile, x-ray shows cavitary infiltrate of left lingula. Culture grows
filamentous gram + rods. Answer choices are

A. Bacillus anthracis

B. Candida

C. Nocardia

D. Pneumocystis

E. Strep bovis - CORRECT ANSWER>>>>C. Nocardia




3

, increased conc estradiol and decrd conc of progesterone. On which of the
following days in this patient`s menstrual cycle were these hormones most
likely measured? A) Day 1

B) Day 6

c) Day 12 D) Day 18

E) Day 26 - CORRECT ANSWER>>>>c) Day 12

1 8/21-Decr Estrogen, Incr Prog

lumbar puncture is performed and the results of polymerase chain reaction
testing of CSF show herpes simplec virus. It is most appropiate to administer a
drug that inhibits which of the following viral enzymes?

Dna polymerase

Neuraminidase

Protease

Reverse transcriptase RNase A - CORRECT ANSWER>>>>DNA polymerase

- [Acyclovir- Guanosine analog. Monophosphorylated by HSV/VZV
thymidine kinase and not phosphorylated in uninfected cells Preferentially
inhibit viral DNA polymerase by chain termination.]

- Neuraminidase- Oseltamivir, zanamivir- Influenza

begins to laugh while eating dinner with his friends. A small particle of food
irritates his larynx and provokes him to cough. Which of the following best
describes the position of his vocal cords throughout this sequence?

While swallowing //Immediately after Laryngeal irritation// While coughing

A. Closed Closed Open

B. Closed Open Closed

4

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