NSG 522 PSYCHOPHARMACOLOGY EXAM
3
COMPLETE
QUESTIONS AND CORRECT VERIFIED
SOLUTIONS LATEST UPDATE
1. Which of the following statements concerning the receptor
subtypes involved in psychostimulant effects is true?
a. the locomotor-stimulating effects of cocaine involve the D5
receptor
b. D2 receptors are required for cocaine self-administration
c. Primozide, a D2 receptor blocker, completely eliminates
amphetamine-induced euphoria
d. D3 Receptor antagonists block the effect of cocaine on
selfstimulation of the brain - CORRECT ANSWER✔✔D. D3
receptor antagonists block the effect of cocaine on
selfstimulation of the brain
2. 12. Cocaine binges
a. may involve use of up to 1500 grams of cocaine
b. result in a period of exhaustion, depression, and cravings
c. Do not produce an abstinence syndrome
d. typically last a week or longer - CORRECT ANSWER✔✔B.
result in a period of exhaustion, depression, and cravings
,2 | Page
3. Cocaine______ and _______ in the striatum can be produced in
addicts by exposure to videos of cocaine-related cues
a. "high"; release of dopamine
b. tolerance; release of glutamate
c. craving; release of dopamine
d. relapse; D2 binding - CORRECT ANSWER✔✔C. Craving;
release of glutamate
4. Cocaine intake in rates given extended access (6 hours/day) to
cocaine_________ while the amount of current needed for
selfstimulation________, which suggests that extensive cocaine
use down-regulates the reward circuit.
a. remained steady; increased
b. increased; increased
c. decreased; decreased
d. increased; decreased - CORRECT ANSWER✔✔b. Increased;
Increased
5. Tolerance to psychostimulants
a. usually occurs following once daily injection of the drug
b. cannot occur in the same paradigm as sensitization
c. is more likely to occur with chronic drug infustions
d. does not develop to the euphoric effects - CORRECT
ANSWER✔✔c. is more likely to occur with chronic drug
infusions
,6. 16. Two drugs currently being investigated for use in treating
cocaine dependence,_______ and ________, are different because
they do not specifically target the _________ system, known to be
involved in cocaine reinforcement
a. Modafinil; disulfiram; dopamine
b. Raclopride; citalopram; glutamate
c. Modafinil; raclopride; gluatmate
d. disulfiram; methylphenidate, dopamine - CORRECT
ANSWER✔✔a. Modafinil; disulfiram; dopamine
17) 17. Vaccines against cocaine
a. have not been effective in producing significant reductions
in cocaine-induced behavior in animal studies
b. have not been tested in humans
c. could act by creating antibodies that bind the cocaine
molecules, reducing the amount of drug that crosses the
blood-brain barrier
d. may create antibodies that break down in the blood stream,
causing long-term toxic side effects - CORRECT
ANSWER✔✔c. Could act by creating antibodies that bind
tehe cocaine molecules, reducing the amount of drug that
crosses the blood-brain barrier
18) 18. The approach of a contingency management program involves
reducing ________ while increasing ___________, and is based on
the idea that drug-taking is an operant response
a. drug-associated reinforcement; nondrug reinforcers
, 4 | Page
b. nondrug reinforces; pharmacotheraeutic use
c. relapse; self-esteem
d. high-risk situations; coping strategies - CORRECT
ANSWER✔✔a. Drug-associated reinforcement; nondrug
reinforces
1) Freebasing
a. is especially dangerous because the ether used to extract
the cocaine is highly flammable.
b. is the procedure used to derive crack cocaine for smoking
c. results in a paste that is 80% cocaine
d. requires that baking soda be mixed with the cocaine during
the extraction process - CORRECT ANSWER✔✔A. is
especially dangerous because the ether used to extract the
cocaine is highly flammable
2) Which of the following about cocaine administration and
absorption is false?
a. The cocaine metabolite benzoylecgonine can be detected
for only a few hours after the last dose of drug.
b. Rapid absorption occurs with intravenous and smoked
forms of cocaine
c. coathylene is a metabolite of cocaine and alcohol that
exerts an effect similar to cocaine, but that lasts for a longer
time
3
COMPLETE
QUESTIONS AND CORRECT VERIFIED
SOLUTIONS LATEST UPDATE
1. Which of the following statements concerning the receptor
subtypes involved in psychostimulant effects is true?
a. the locomotor-stimulating effects of cocaine involve the D5
receptor
b. D2 receptors are required for cocaine self-administration
c. Primozide, a D2 receptor blocker, completely eliminates
amphetamine-induced euphoria
d. D3 Receptor antagonists block the effect of cocaine on
selfstimulation of the brain - CORRECT ANSWER✔✔D. D3
receptor antagonists block the effect of cocaine on
selfstimulation of the brain
2. 12. Cocaine binges
a. may involve use of up to 1500 grams of cocaine
b. result in a period of exhaustion, depression, and cravings
c. Do not produce an abstinence syndrome
d. typically last a week or longer - CORRECT ANSWER✔✔B.
result in a period of exhaustion, depression, and cravings
,2 | Page
3. Cocaine______ and _______ in the striatum can be produced in
addicts by exposure to videos of cocaine-related cues
a. "high"; release of dopamine
b. tolerance; release of glutamate
c. craving; release of dopamine
d. relapse; D2 binding - CORRECT ANSWER✔✔C. Craving;
release of glutamate
4. Cocaine intake in rates given extended access (6 hours/day) to
cocaine_________ while the amount of current needed for
selfstimulation________, which suggests that extensive cocaine
use down-regulates the reward circuit.
a. remained steady; increased
b. increased; increased
c. decreased; decreased
d. increased; decreased - CORRECT ANSWER✔✔b. Increased;
Increased
5. Tolerance to psychostimulants
a. usually occurs following once daily injection of the drug
b. cannot occur in the same paradigm as sensitization
c. is more likely to occur with chronic drug infustions
d. does not develop to the euphoric effects - CORRECT
ANSWER✔✔c. is more likely to occur with chronic drug
infusions
,6. 16. Two drugs currently being investigated for use in treating
cocaine dependence,_______ and ________, are different because
they do not specifically target the _________ system, known to be
involved in cocaine reinforcement
a. Modafinil; disulfiram; dopamine
b. Raclopride; citalopram; glutamate
c. Modafinil; raclopride; gluatmate
d. disulfiram; methylphenidate, dopamine - CORRECT
ANSWER✔✔a. Modafinil; disulfiram; dopamine
17) 17. Vaccines against cocaine
a. have not been effective in producing significant reductions
in cocaine-induced behavior in animal studies
b. have not been tested in humans
c. could act by creating antibodies that bind the cocaine
molecules, reducing the amount of drug that crosses the
blood-brain barrier
d. may create antibodies that break down in the blood stream,
causing long-term toxic side effects - CORRECT
ANSWER✔✔c. Could act by creating antibodies that bind
tehe cocaine molecules, reducing the amount of drug that
crosses the blood-brain barrier
18) 18. The approach of a contingency management program involves
reducing ________ while increasing ___________, and is based on
the idea that drug-taking is an operant response
a. drug-associated reinforcement; nondrug reinforcers
, 4 | Page
b. nondrug reinforces; pharmacotheraeutic use
c. relapse; self-esteem
d. high-risk situations; coping strategies - CORRECT
ANSWER✔✔a. Drug-associated reinforcement; nondrug
reinforces
1) Freebasing
a. is especially dangerous because the ether used to extract
the cocaine is highly flammable.
b. is the procedure used to derive crack cocaine for smoking
c. results in a paste that is 80% cocaine
d. requires that baking soda be mixed with the cocaine during
the extraction process - CORRECT ANSWER✔✔A. is
especially dangerous because the ether used to extract the
cocaine is highly flammable
2) Which of the following about cocaine administration and
absorption is false?
a. The cocaine metabolite benzoylecgonine can be detected
for only a few hours after the last dose of drug.
b. Rapid absorption occurs with intravenous and smoked
forms of cocaine
c. coathylene is a metabolite of cocaine and alcohol that
exerts an effect similar to cocaine, but that lasts for a longer
time
