ANATOMY NBME ASSESSMENT TEST 2026
TESTED QUESTIONS WITH FULL SOLUTION
GRADED A+
◉ Neutrophils produce reactive oxygen compounds following the
phagocytosis of bacteria. Which of the following enzymes protects
body tissues against these highly reactive oxygen compounds?
A. Cyclooxygenase
B. Lipoxygenase
C. Myeloperoxidase
D. Superoxide dismutase
E. Xanthine oxidase. Answer: D. Superoxide dismutase
◉ 55 year old man with a long history of poorly controlled
hypertension suddenly develops severe retrosternal chest pain that
radiates into the upper back between the scapulae. On examination,
he has diaphoresis and severe SOB. Pulse is 125/min and regular,
and bp is 130/60mmHg in the left arm and 80/50mmHg in the right
arm. There are diffuse, wet, inspiratory crackles in both lung fields,
distant heart sounds, and previously undetected grade 2/6, blowing,
early diastolic murmur in the second right and third left intercostal
spaces adjacent to the sternum. The most likely diagnosis is:
A. Dissecting aortic aneurysm
B. Myocardial infarction
,C. Pericarditis with tamponade
D. Pulmonary embolism
E. Ruptured chordae tendineae
F. Ventricular septal rupture. Answer: A. Dissecting aortic aneurysm
◉ 40-year old man is brought to the ED after being exposed to ozone
and nitrogen dioxide at a factory. He dies shortly thereafter. At
autopsy, examination of tissue taken from a lung biopsy suggests
damage to his alveolar epithelium. If he had survived, this layer
would have likely been regenerated within several weeks by which
of the following cells?
A. Clara cells
B. Endothelial cells
C. Reticular cells
D. Type I pneumocytes
E. Type II pneumocytes. Answer: E. Type II pneumocytes
◉ 32 year old man has had malaise, a low grade fever and a 4.5kg
weight loss over the last 3 months. He has unilateral cerivcal
lymphadenopathy. Examination of tissue obtained on biopsy of a
lymph node shows Hodgkin's disease, nodular sclerosing type. The
most likely cause of the anemia is:
A. abnormal utilization of iron
B. extravascular hemolysis
,C. folate deficiency
D. iron deficiency
E. marrow aplasia. Answer: A. abnormal utilization of iron
◉ 25-year old man is brought to the ED because of palpitations and
anxiety. A friend says the patient was smoking "crack" earlier in the
evening. Blood pressure is 180/110mmHg and pulse is 120/min.
ECG shows sinus tachycardia. Which of the following is the most
likely cause of these findings?
A. block of neurotransmitter uptake at the presynaptic nerve
terminal
B. excess release of acetylcholine at neuromuscular junctions
C. increased metabolism of neurotransmitters within neuromuscular
junctions
D. increased release of neurotransmitters at the presynaptic nerve
terminals
E. release of endorphins and enkephalins into the circulation.
Answer: A. block of neurotransmitter uptake at the presynaptic
nerve terminal
◉ Normal healthy children are able to mount diverse antibody
responses to several thousands of different antigens. This process is
based primarily on which of the following DNA mechanisms?
A. Amplification
B. Conformation
, C. Recombination
D. Repair
E. Replication. Answer: C. Recombination
◉ The sulfonylureas exert their hypoglycemic effect by blocking
which of the following channels:
A. Ca2+
B. Cl-
C. K+
D. Mg2+
E. Na+. Answer: C. K+
◉ 800 motor vehicle collisions occurred over 2 years in a city. 600 of
these accidents were alcohol related. During the same period, there
were 400 fatalities due to motor vehicle collisions, of which 75%
were alcohol-related. Which of the following best represents the 1-
year incidence of alcohol-related motor vehicle fatalities in this
community?
A. 150 per 600,000
B. 300 per 600,000
C. 450 per 600,000
D 600 per 600,000
E. Unable to determine from available info. Answer: B. 300 per
600,000
TESTED QUESTIONS WITH FULL SOLUTION
GRADED A+
◉ Neutrophils produce reactive oxygen compounds following the
phagocytosis of bacteria. Which of the following enzymes protects
body tissues against these highly reactive oxygen compounds?
A. Cyclooxygenase
B. Lipoxygenase
C. Myeloperoxidase
D. Superoxide dismutase
E. Xanthine oxidase. Answer: D. Superoxide dismutase
◉ 55 year old man with a long history of poorly controlled
hypertension suddenly develops severe retrosternal chest pain that
radiates into the upper back between the scapulae. On examination,
he has diaphoresis and severe SOB. Pulse is 125/min and regular,
and bp is 130/60mmHg in the left arm and 80/50mmHg in the right
arm. There are diffuse, wet, inspiratory crackles in both lung fields,
distant heart sounds, and previously undetected grade 2/6, blowing,
early diastolic murmur in the second right and third left intercostal
spaces adjacent to the sternum. The most likely diagnosis is:
A. Dissecting aortic aneurysm
B. Myocardial infarction
,C. Pericarditis with tamponade
D. Pulmonary embolism
E. Ruptured chordae tendineae
F. Ventricular septal rupture. Answer: A. Dissecting aortic aneurysm
◉ 40-year old man is brought to the ED after being exposed to ozone
and nitrogen dioxide at a factory. He dies shortly thereafter. At
autopsy, examination of tissue taken from a lung biopsy suggests
damage to his alveolar epithelium. If he had survived, this layer
would have likely been regenerated within several weeks by which
of the following cells?
A. Clara cells
B. Endothelial cells
C. Reticular cells
D. Type I pneumocytes
E. Type II pneumocytes. Answer: E. Type II pneumocytes
◉ 32 year old man has had malaise, a low grade fever and a 4.5kg
weight loss over the last 3 months. He has unilateral cerivcal
lymphadenopathy. Examination of tissue obtained on biopsy of a
lymph node shows Hodgkin's disease, nodular sclerosing type. The
most likely cause of the anemia is:
A. abnormal utilization of iron
B. extravascular hemolysis
,C. folate deficiency
D. iron deficiency
E. marrow aplasia. Answer: A. abnormal utilization of iron
◉ 25-year old man is brought to the ED because of palpitations and
anxiety. A friend says the patient was smoking "crack" earlier in the
evening. Blood pressure is 180/110mmHg and pulse is 120/min.
ECG shows sinus tachycardia. Which of the following is the most
likely cause of these findings?
A. block of neurotransmitter uptake at the presynaptic nerve
terminal
B. excess release of acetylcholine at neuromuscular junctions
C. increased metabolism of neurotransmitters within neuromuscular
junctions
D. increased release of neurotransmitters at the presynaptic nerve
terminals
E. release of endorphins and enkephalins into the circulation.
Answer: A. block of neurotransmitter uptake at the presynaptic
nerve terminal
◉ Normal healthy children are able to mount diverse antibody
responses to several thousands of different antigens. This process is
based primarily on which of the following DNA mechanisms?
A. Amplification
B. Conformation
, C. Recombination
D. Repair
E. Replication. Answer: C. Recombination
◉ The sulfonylureas exert their hypoglycemic effect by blocking
which of the following channels:
A. Ca2+
B. Cl-
C. K+
D. Mg2+
E. Na+. Answer: C. K+
◉ 800 motor vehicle collisions occurred over 2 years in a city. 600 of
these accidents were alcohol related. During the same period, there
were 400 fatalities due to motor vehicle collisions, of which 75%
were alcohol-related. Which of the following best represents the 1-
year incidence of alcohol-related motor vehicle fatalities in this
community?
A. 150 per 600,000
B. 300 per 600,000
C. 450 per 600,000
D 600 per 600,000
E. Unable to determine from available info. Answer: B. 300 per
600,000
