Nursing 54A - Cortisol. Cox Inhibitors and Meds for Bones and Joints. Study Guide.

Cyclooxygenase Inhibitors: Nonsteroidal Anti-inflammatory Drugs and Acetaminophen  What makes these drugs similar? All Cyclooxygenase Inhibitors  Acetaminophen - not anti inflammatory  Ace- enzyme  Inhibition of the prostagladin process  In general, the effects of prostaglandin -are not all negative effects Classification COX inhibitors  1st and 2nd gen- based on Selectivity  1st gen- Inhibits all COX  2nd gen- target the bad prostaglandin  One is considered more helpful and one is more related to inflammation  BB 1st and 2nd gen- Selectivity made the difference COX inhibitors and acetaminophen • COX 1 “good” – Housekeeper • Cox 2 “bad” – Works at sites of inflammation and pain – Brain :fever and pain – Kidney: supports renal function – Blood vessels: vasodilator – Colon: contributes to colon cancer  Some enzymatic action is a good thing- stomach, kidneys (good and bad) and platelets (stim. platelet aggregation)