NUR 210 Pharmacology Principles Exam 1 (250+ Questions) NUR 210 – ADME, Drug Interactions, Pharmacokinetics | Chamberlain University

MATERIAL PHARMACOLOGY
PRINCIPLES NUR 210 EXAM 1|
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drug response - 🧠 ANSWER ✔✔the intensity of the drug response is

directly related to the concentration of the drug at the SITE OF ACTION

,Goal is to:

- maximize the beneficial effects- concentration high enough for desired

response

- minimize harm- avoid to high a concentration


Three phases of drug action - 🧠 ANSWER ✔✔1. pharmaceutic phase

(dissolution)

2. pharmacokinetic phase (drug moving through the body)

3. pharmacodynamic phase (what the drug does to the body)


1. pharmaceutic phase - 🧠 ANSWER ✔✔the drug goes into solution




- Dissolution: the process by which a drug goes into solution and becomes

available for absorption




- must be dissolved before it can be absorbed

- most absorption takes place in the small intestine


2. pharmacokinetic phase: four processes - 🧠 ANSWER ✔✔"what the

BODY does to the drug"

,- absorption

- distribution

- metabolism/ biotransformation

- exertion


pharmacokinetic phase: Absorption - 🧠 ANSWER ✔✔(small intestine) the

movement of a drug from its site of administration into the blood


pharmacokinetic phase: Distribution - 🧠 ANSWER ✔✔drug moves from

blood --> cell membrane

pharmacokinetic phase: Metabolism/biotransformation - 🧠 ANSWER

✔✔lipid soluble metabolite (liver) --> a water soluble metabolite


pharmacokinetic phase: Excretion - 🧠 ANSWER ✔✔water soluble

metabolite (kidneys)


liver - 🧠 ANSWER ✔✔breaks down the drug


kidneys - 🧠 ANSWER ✔✔excretes the drug




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, Pharmacokinetic phase movement process - 🧠 ANSWER ✔✔orally -->

stomach --> SI --> bloodstream --> site of action --> liver (broken down) -->

kidneys (excreted)




IV --> bloodstream --> cite of action --> liver --> kidneys

drugs crossing the cell membranes phospholipid cell layer - 🧠 ANSWER

✔✔-drugs must be LIPID SOLUBLE in order to pass through the

membrane




- WATER SOLUBLE drugs penetrate the cell membrane through channels

and pores

Absorption




1. direct penetration of the membranes

2. channels and pores


3. transport systems - 🧠 ANSWER ✔✔the movement of a drug from its site

of administration to the blood