MYELOPROLIFERATIVE DISORDERS (MPDs)
Definition:
Myeloproliferative disorders (MPDs) are clonal myeloid stem cell abnormalities leading to
qualitative and quantitative changes in erythroid, myeloid and platelet cells (mainly in the middle
aged and other patients). In another dimension, MPDs are group of blood diseases in which the
bone marrow produces too many blood cells. The excess marrow can be too many red cells,
white blood cells or platelets and this leads to problems with blood circulation, clotting or
bleeding (the bone marrow is always hyperactive).
Principle:
The abnormalities lead to clonal expansion of the stem cell causing excessive production of one
or more cell lines.
Types of MPDs:
These are six most important diseases related to MPDs:
① Polycythemia vera (PV)
② Chronic Granulocytic leukemia (CML)
③ Primary Myelofibrosis (PM)
④ Essential Thrombocytosis (ET)
⑤ Chronic myelogenous leukemia (CML)
⑥ Chronic Eosinophilic leukemia (CEL)
Polycythemia Vera (PV):
Polycythemia vera is a type of blood cancer. It causes your bone marrow to make too many red
blood cells. These excess cells thicken your blood, slowing its flow which may cause serious
problems such as blood clot. Most cases are due to JAK2 mutation (95% of patients). This
mutation makes the bone marrow produce red blood cells even when they are not needed.
Erythropoietin (EPO) level becomes low because the body senses high RBC mass.
CHRONIC GRANULOCYTIC LEUKEMIA (CML)
Chronic Granulocytic Leukemia is a myeloproliferative disorder in which the bone marrow
produces too many granulocytes (a type of white blood cell) - neutrophils, eosinophils, and
basophils. High white blood cell increase uncontrollably causing high white blood cell count. It is
Definition:
Myeloproliferative disorders (MPDs) are clonal myeloid stem cell abnormalities leading to
qualitative and quantitative changes in erythroid, myeloid and platelet cells (mainly in the middle
aged and other patients). In another dimension, MPDs are group of blood diseases in which the
bone marrow produces too many blood cells. The excess marrow can be too many red cells,
white blood cells or platelets and this leads to problems with blood circulation, clotting or
bleeding (the bone marrow is always hyperactive).
Principle:
The abnormalities lead to clonal expansion of the stem cell causing excessive production of one
or more cell lines.
Types of MPDs:
These are six most important diseases related to MPDs:
① Polycythemia vera (PV)
② Chronic Granulocytic leukemia (CML)
③ Primary Myelofibrosis (PM)
④ Essential Thrombocytosis (ET)
⑤ Chronic myelogenous leukemia (CML)
⑥ Chronic Eosinophilic leukemia (CEL)
Polycythemia Vera (PV):
Polycythemia vera is a type of blood cancer. It causes your bone marrow to make too many red
blood cells. These excess cells thicken your blood, slowing its flow which may cause serious
problems such as blood clot. Most cases are due to JAK2 mutation (95% of patients). This
mutation makes the bone marrow produce red blood cells even when they are not needed.
Erythropoietin (EPO) level becomes low because the body senses high RBC mass.
CHRONIC GRANULOCYTIC LEUKEMIA (CML)
Chronic Granulocytic Leukemia is a myeloproliferative disorder in which the bone marrow
produces too many granulocytes (a type of white blood cell) - neutrophils, eosinophils, and
basophils. High white blood cell increase uncontrollably causing high white blood cell count. It is
