NBME CBSE Actual Test: Complete Question Bank with Correct Answers | USMLE Step 1 Medical Examination Study Guide | Latest 2025/2026 Updates

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NBME CBSE Actual Test –
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Complete Questions and Correct A
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nswers | USMLE Step 1
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Medical Examination Quiz Bank a
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nd Study Guide (Latest
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2025/2026 Updates) I

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62IyearIoldIwomanI-IosteoporosisI–
IaIbisphosphonateIisIprescribed.ITheIexpectedIbeneficialIeffectIofItheIdrugIisIdueItoIwhichIofItheIfollowin

g?I

DecreasedIOsteoclastIActivityI

CohotIStudyIofIelderlyIwomenI–
IrelativeIriskIratioIforIhipIfracturesIamongIthoseIwhoIexerciseIregularlyIisI1.2I(95%IconfidenceIintervalIo

fI1.1ItoI1.8).IWhichIofItheIfollowingIisItheIconclusionIaboutItheIeffectIofIexerciseIonItheIriskIofIhipIfractu
re?I

StatisticallyISignificantIOverallIIncreaseIRiskI
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00:03I
00:49I

52IyearIoldImanIgoesItoIERIwithIchestIpainIradiatingItoIhisIjawIwhileIshovelingIsnow.IPulseIisI80/minIandI
bloodIpressureIisI130/70.ITheImostIimmediateItreatmentImechanismIofIaction?I

IncreasedInitricIoxideIconcentrationI

24IyearIoldIwomanI–IspilledIhotIgreaseIonIherIleftIlegIwhileIworkingIatIaIfast-
foodIrestaurant.IExamIofIlegIshowsI7cmIpink,Isoft,Igranular,IedematousIwound.ITheIformationIofIthisItiss
ueIwasImostIlikelyIcausedIbyIincreasedIactivityIofIwhich?I

a.IVascularIEndothelialIGrowthIFactorI

VEGFI–IstimulatesIangiogenesiss.I

TYPEIIIIICollagenI=IBloodIVesselsI–IearlyIwoundIrepairI
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27IyearIoldIman-IMVCI–IskullIx-rayIshowsIaIlinear,InondepressedIbasalIskullIfractureI–
IincreasedIserumIosmIandIdecreasedIurinIosm.IFollowingIdesmopressinIurineIosmIincreases.IDesmo

pressin’sIeffectIisIdueItoItheIactivationIofIwhichIofItheIfollowing?I

a.IAdenylylICyclaseI

AdenylateICyclaseI–IATPI–ICAMPI--IPROTEKINASEIAI--ICaIv2I

, I

AI10ImonthIoldIboyI–
I4IdayIhistoryIofIfeverIandIcough.IHeIattendsIdayIcareIcenter.IChestIexamIshowsIintercostalIretractionsIal

ongIwithIbilateral,IdiffuseIwheezesIandIexpiratoryIrhonchi.ITheIinfectiousIagentImostIlikelyIhasIwhichIof
ItheIfollowingIproperties?I



MediationIofICellIEntryIviaIaIfusionIproteinI

AI17IyearIoldIgirlIinIEDI–
I15IminutesIafterIbeingIstungIbyIaIbee.IMildIlightIheadednessIbutInoIdifficultyIswallowing-

IBilateralIwheezingI-IWhichIisImostIappropriateIpharmacotherapyIforIthisIpatient?I



B2-IAgonistI

14IyearIoldIboyI-
I2IdayIhistoryIofIsoreIthroatIandIfeverIthatIpeaksIinIlateIafternoon.I1IweekIofIfatigue.IHeIrecentalyIhadIsexI

withIoneIpartner.IPhysicalIexamIshowIcervicalIlymphadenopathyIandIpharyngealIerythemaIwithIaIcreamy
Iexudate.IDX?I



InfectiousIMononucleosisI

57IyearIoldImanI–
IradiationItherapyIforIsquamousIcellIcarcinomaIofItheIlung.IDespiteItherapy,ItumorIincreasesIinIsizeIand

IheIdiesI6ImonthsIlater.ITheIprogressiveItumorIgrowthIisIdueItoIaIdefectIinIcellIcycleIarrestIinIwhichIofIth

eIfollowingIphasesIofIcellIcycle?I

G1I
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28IyearIoldI–IlivedIinIsub-SaharanIAfricaI–IuntilIheIcameItoItheIUS.ITempIofI100.4I–
IimagingIshowsIbilateralIhydroureterIandIhydronephrosis.IBiopsyIshowsImarkedIfibrosisIandIscattere

dIgranulomas.IDX?I

SchistosomiasisI

AIcoupleIwithIaIfamilyIhistoryIofIa-
thalassemia.IWomanIhasIoneIgeneIdeletionIandImanIhasItwoIgeneIdeletion.IIfItheItwoIgeneIisItransI–
IwhatIpercentageIofIoffspringIwillIhaveIaItwoIgeneIdeletion?I



50%I

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previouslyIhealthyI40IyearIbroughtItoIemergencyIdepartmentIbyIherIhusbandI–
I2IdayIhistoryIofIfever,Ilethargy,Iconfusion.IPEIshowsIscatteredIpetechiaeIandIecchymosesIoverItheIlower

IextremitiesI–I3+IpolychromasiaIandI3+IschistocytesIandILowIplateletsIDx?I



ThromboticIThrombocytopeniaIPurpuraI

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00:49I

16IyearIoldIboyI–IisIadmittedItoItheIERIbecauseIofIaIknifeIwoundItoItheIleftIsideIofIhisIchest.IAnIX-
rayIofItheIchestIshowsIanIair-
fluidIlevelIinItheIleftIsideIofItheIchest,IpartialIcollapseIofItheIleftIlung,IandItheIelevationIofItheIstomachIb
ubble.ITheImediastinumIisImidline.IDX?I

HemopneumpothoraxIunderItensionI

49IyearIoldIwomanI–IcoronaryIarteryIdiseaseI–IBPI140/90I-
HighICholesterol,IHighILDLI(190),IHighItriglyceridesI(350)I–
I


TXIwithIatorvastatinIandIlosartan.IWhatIareItheIeffectsIonIHDLIandITriglycerides?IHDLIincreasedI
I



TriglyceridesIDecreasedI
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73IyeareIoldI–
IdiffuseIweaknessIandItinglingIofIherIarmsIandIlegs.ISensationIandIvibrationIandIpositionIisIdecreasedIinIa

llIextremities.IWhatIvitaminIdeficiency?I

VitaminIB12I–I(cyanocobalamin)I

TeaIandIToastI–IlowIB12IinIdietI




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15IyearIoldIgirlI–I3ImonthIhistoryIofIacneI–IwhichIisItheIunderlyingIcauseIofItheIpatientsIacne?I