QUESTIONS AND ACCURATE ANSWERS
GUARANTEED PASS GRADED A+
⩥Factors that affect drug absorption (5). Answer: Rate of dissolution
Surface area
Blood flow
Lipid solubility
PH partitioning
⩥Factors that affect drug distribution (4). Answer: Blood flow to tissues
Ability to exit vascular system
Blood-brain barrier
Protein-binding capacity
⩥Pharmacodynamics. Answer: The study of biochemical and
physiologic effects of drugs on the body and the molecular mechanisms
by which those effects are produced
"What the body does to the drug"
⩥Phamacodynamics: 3 mechanisms of action. Answer: Receptor
Enzyme
,Non-selective interactions (i.e. chemo)
⩥Types of drug therapy (7). Answer: Acute
Maintenance (HTN/bc)
Supplemental (insulin)
Palliative
Supportive (IV fluid)
Prophylactic
Empirical (broad-spectrum abx)
⩥Idiosyncratic Effect. Answer: Unexpected response to medication
⩥Tolerance. Answer: Declining response to a drug
⩥Dependence. Answer: Physiological/psychological need for a drug;
needs drug for normal function
⩥Addiction. Answer: Compulsive use of a drug despite
negative/dangerous effects
⩥Drug interactions: drug-drug. Answer: When 2 drugs compete for
metabolizing enzymes
, ⩥Drug interactions: food-drug. Answer: Grapefruit juice or leafy greens
⩥Drug interactions: additive. Answer: 1+1 = 2; both provide intended
effect
⩥Drug interactions: antagonistic. Answer: 1+1 = <2; less than desired
effect of one or both drugs
⩥Drug interactions: synergistic. Answer: 1+1 = >2; sum total effect is
greater than if given alone (i.e. lisinopril + HCTZ)
⩥Drug interactions: incompatibility. Answer: 1+1 does not equal 2; two
IV drugs given together causing decomposition of one or both drugs
⩥8 rights of medication administration. Answer: Patient
Medication
Dose
Route
Time
Reason
Response
Documentation