Advanced Pathophysiology MidTerm
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Hypochromic anemia - ANSWERS-RBCs with less hemoglobin than normal. As a result,
the RBCs appear pale in color (MCHC is low).
Hyperchromic anemia - ANSWERS-RBCs with more hemoglobin than normal. As a
result, the RBCs appear a dark hue or red than normal cells (MCHC is high).
Normochromic anemia - ANSWERS-RBCs that have a normal amount of hemoglobin.
As a result, the RBCs appear neither pale nor dark (MCHC is normal).
Autoimmunity - ANSWERS-Autoimmune disease can be familial, Affected family
members may not all develop the same disease, but several members may have
different disorders characterized by a variety of hypersensitivity reactions, These
include autoimmune and allergic reactions
Associations with particular autoimmune diseases have been identified for a variety of
major histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity - ANSWERS-General term used to describe when an individual's immune
system reacts against antigens on the tissues of other members of the same species.
, Examples: Neonatal disease where the maternal immune system becomes sensitized
against antigens expressed by the fetus, Transplant rejection, Transfusion reaction
Primary Immunodeficiency - ANSWERS-Most primary immune deficiencies are result of
single gene defects.Something is lacking with the immune system itself.
Example: B-lymphocyte deficiency - one of the most severe forms of a primary
immunodeficiency
Secondary Immunodeficiency - ANSWERS-Complication of some other physiological
condition/disease, Malnutrition one of most common causes worldwide. Example: Pt.
with HIV gets pneumocystis carinii
Hematology - ANSWERS-Anemias, Involve RBCs, Most of body's iron stores come
from the recycling of iron from old RBCs
Iron Deficiency Anemia - ANSWERS-Microcytic/Hypochromic Anemia, Caused by
disorders of hemoglobin synthesis, particularly iron deficiency, Ferritin is an important
measurement that reflects the body's total iron stores, The NP will order a ferritin level
to get an idea of the body's total iron stores, Low ferritin reflects anemia
Major Lab Marker for Anemia - ANSWERS-Increased RBC distribution width (RDW) is
one of the earliest lab markers in developing microcytic or macrocytic anemia
COPD - ANSWERS-Diagnosis based on Hx of symptoms, physical exam, chest
imaging, pulmonary function tests and blood gas analysis
Pulmonary function testing reveals airway obstruction (decreased FEV1) that is
progressive and unresponsive to bronchodilators, Emphysema, Chronic bronchitis
COPD Staging According to GOLD Guidelines- Based on degree of airway limitation -
ANSWERS-Gold 1: Mild: FEV1≥80% predicted
Gold 2: Moderate: 50% ≤FEV1 <80% predicted
Gold 3: Severe: 30% ≤FEV1 <50% predicted
Gold 4: Very Severe: FEV < 30% predicted