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The study of drug absorption, distribution, metabolism, and excretion is known as
A. pharmacotherapeutics
B. pharmacodynamics
C. pharmacokinetics
D. pharmacy
E. posology - ANSWERS-C. pharmacokinetics
The main pharmacologic effect of norepinephrine on alpha-1 receptors is
A. increased heart rate
B. bronchodilation
C. vasoconstriction
D. contraction of urinary bladder
E. increased force of myocardial contraction - ANSWERS-C. vasoconstriction
The pharmacologic effect of IV metaraminol (an alpha-1 drug) is
A. vasodilation
B. vasoconstriction
C. cardiac stimulation
D. cardiac depression
,E. bronchodilation - ANSWERS-B. vasoconstriction
Epinephrine stimulates
A. alpha-1 receptors
B. alpha-2 receptors
C. beta-1 receptors
D. beta-2 receptors
E. all of these - ANSWERS-E. all of these
At therapeutic doses, albuterol stimulates
A. alpha-1 receptors
B. alpha-2 receptors
C. beta-1 receptors
D. beta-2 receptors
E. all of these - ANSWERS-D beta-2 receptors
Metoprolol is classified as a(n)
A. alpha-blocker
B. nonselective beta-blocker
C. selective beta-1 blocker
D. adrenergic neuronal blocker
E. selective beta-2 blocker - ANSWERS-C. selective beta-1 blocker
A 36-year-old male has been diagnosed with chronic myeloid leukemia. His oncologist
discusses treatment options with him. The patient is glad to hear that novel anticancer
drugs used to treat chronic myeloid leukemia have a much better risk-benefit ratio than
older ones, due to their improved selectivity. A major determinant for the selectivity of a
given drug is
A) its target receptor ligand affinity.
B) its target receptor cell-type distribution.
, C) its ionic interactions.
D) its hydrogen bonding.
E) its intrinsic activity. - ANSWERS-B its target receptor cell-type distribution.
A 56-year-old man with chest pain is diagnosed with stable angina and treated with
several drugs including nitroglycerin. Every day he has to discontinue nitroglycerin for
some hours to re-establish reactivity of his body to the drug. The clinical observation of
a rapidly decreasing response to nitroglycerin after administration of just a few doses is
called
A.idiosyncrasy.
B.tachyphylaxis.
C.heterologous desensitization.
D.refractoriness.
E.receptor downregulation. - ANSWERS-B tachyphylaxis.
Prolonged receptor stimulation during chronic drug therapy may induce cells to
endocytose and sequester drug receptors in endocytic vesicles. This molecular
mechanism is called
A) tachyphylaxis.
B) inactivation.
C) desensitization.
D) downregulation.
E) refractoriness. - ANSWERS-D downregulation.
The mechanism of action of methyldopa is
A. increased release of NE from adrenergic nerve ending
B. alpha-1 receptor blocker
C. beta-1 receptor blocker
D. formation of a false transmitter in adrenergic nerve ending
E. none of these - ANSWERS-D formation of a false transmitter in adrenergic nerve
ending