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HESI Comprehensive Exam Q&A (1000+ Questions) – Med-Surg, Pharmacology, OB, Pediatrics & Mental Health – 2026, Nursing

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This document contains over 1000 exam-style questions with verified answers for the HESI Comprehensive Exam, covering a broad range of nursing topics essential for final exam and NCLEX preparation. It includes detailed content in medical-surgical nursing, pharmacology, maternal-newborn (OB), pediatrics, mental health, and critical care, with emphasis on clinical decision-making, prioritization, and patient safety. As shown on page 1, the document begins with pharmacology-based clinical judgment questions (e.g., enalapril and blood pressure assessment), and throughout the document it expands into complex patient care scenarios such as cardiac emergencies, electrolyte imbalances, psychiatric care, maternity complications, and chronic disease management. The material integrates rationales for each answer, reinforcing critical thinking and evidence-based nursing practice. The content is structured in a comprehensive question-and-answer format with detailed rationales, making it highly effective for deep learning, self-assessment, and exam readiness. It aligns with HESI and NCLEX-RN standards and is based on widely used textbooks such as Saunders Comprehensive Review for the NCLEX-RN Examination and HESI Comprehensive Review for the NCLEX-RN. This document is highly relevant for students enrolled in Nursing (RN, BSN, ADN), Pre-Nursing, and Health Science programs. It is particularly useful for those preparing for HESI exit exams, NCLEX-RN, and final comprehensive nursing assessments. It is also valuable for nursing students across specialties including Medical-Surgical, Pediatrics, Obstetrics, and Mental Health Nursing, as well as for healthcare trainees aiming to strengthen clinical reasoning and exam performance. Keywords: HESI, nursing exam, NCLEX prep, medical surgical nursing, pharmacology, pediatrics, obstetrics, mental health, critical care, patient safety, clinical judgment, prioritization, nursing interventions, pathophysiology

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HESI Comprehensive Exam 2026
Exam Questions and Verified
Answers | Already Graded A+



Enalapril maleate is prescribed for a hospitalized client. Which assessment

does the nurse perform as a priority before administering the medication?




Checking the client's blood pressure

Checking the client's peripheral pulses

,Checking the most recent potassium level

Checking the client's intake-and-output record for the last 24 hours - 🧠

ANSWER ✔✔Checking the client's blood pressure




Rationale: Enalapril maleate is an angiotensin-converting enzyme (ACE)

inhibitor used to treat hypertension. One common side effect is postural

hypotension. Therefore the nurse would check the client's blood pressure

immediately before administering each dose. Checking the client's

peripheral pulses, the results of the most recent potassium level, and the

intake and output for the previous 24 hours are not specifically associated

with this mediation.

A client is scheduled to undergo an upper gastrointestinal (GI) series, and

the nurse provides instructions to the client about the test. Which statement

by the client indicates a need for further instruction?




"The test will take about 30 minutes."

"I need to fast for 8 hours before the test."

,"I need to drink citrate of magnesia the night before the test and give

myself a Fleet enema on the morning of the test."

"I need to take a laxative after the test is completed, because the liquid that

I'll have to drink for the test can be constipating." - 🧠 ANSWER ✔✔"I need

to drink citrate of magnesia the night before the test and give myself a Fleet

enema on the morning of the test."




Rationale: No special preparation is necessary before a GI series, except

that NPO (nothing by mouth) status must be maintained for 8 hours before

the test. An upper GI series involves visualization of the esophagus,

duodenum, and upper jejunum by means of the use of a contrast medium.

It involves swallowing a contrast medium (usually barium), which is

administered in a flavored milkshake. Films are taken at intervals during the

test, which takes about 30 minutes. After an upper GI series, the client is

prescribed a laxative to hasten elimination of the barium. Barium that

remains in the colon may become hard and difficult to expel, leading to

fecal impaction.

A nurse on the evening shift checks a primary health care provider's

prescriptions and notes that the dose of a prescribed medication is higher


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, than the normal dose. The nurse calls the primary health care provider's

answering service and is told that the primary health care provider is off for

the night and will be available in the morning. What should the nurse do

next?




Call the nursing supervisor

Ask the answering service to contact the on-call primary health care

provider

Withhold the medication until the primary health care provider can be

reached in the morning

Administer the medication but consult the primary health care provider

when he becomes available - 🧠 ANSWER ✔✔Ask the answering service to

contact the on-call primary health care provider




Rationale: The nurse has a duty to protect the client from harm. A nurse

who believes that a primary health care provider's prescription may be in

error is responsible for clarifying the prescription before carrying it out.

Therefore the nurse would not administer the medication; instead, the

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