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GALEN NUR 253 Mental Health Nursing Exam 2 2026: 300 Questions with Rationales – Substance Use, Crisis, Suicide, Child/Adolescent, Geriatrics & More

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Pass the GALEN NUR 253 Mental Health Nursing Exam 2 on your first attempt with this comprehensive 2026 study guide featuring 300 practice questions and detailed rationales. Designed for nursing students, this resource covers every high-yield topic tested on the exam. Sections covered include: Substance use disorders – alcohol withdrawal (CIWA-Ar, benzodiazepines, DT, Wernicke-Korsakoff, thiamine), opioid use disorder (naloxone, methadone, buprenorphine, suboxone), stimulants (cocaine, methamphetamine – avoid beta-blockers), benzodiazepine withdrawal (slow taper, seizure risk), disulfiram reaction, naltrexone, acamprosate Crisis intervention & disaster response – situational vs maturational crisis, phases of disaster, crisis intervention (4-6 weeks), suicide hotline, sexual assault (SAFE exam), de-escalation Suicide prevention & risk assessment – prior attempt strongest predictor, older white male highest risk, antidepressants black box warning (first 1-2 weeks), lithium anti-suicidal effect, safety plan vs no-suicide contract, means reduction (firearms, ligature points), 72-hour hold Child & adolescent psychiatric disorders – ADHD (stimulants first-line, side effects: insomnia, appetite loss, growth delay), autism spectrum disorder (risperidone for irritability, ABA therapy, melatonin for sleep), conduct disorder (progression to antisocial PD), oppositional defiant disorder (parent management training) Older adult mental health – delirium (acute, fluctuating, caused by UTI/medications) vs dementia (chronic, progressive), Alzheimer's (cholinesterase inhibitors: donepezil, rivastigmine; memantine), sundowning, wandering safety, Lewy body dementia (antipsychotic sensitivity), frontotemporal dementia, pseudodementia (depression in elderly), Beers criteria (anticholinergics avoid) Family violence, abuse & trauma – mandatory reporting (CPS, APS), IPV screening (ask alone), safety plan, strangulation assessment, human trafficking indicators, Munchausen by proxy, emotional abuse reportable Sexual disorders & gender dysphoria – erectile dysfunction (PDE5 inhibitors contraindicated with nitrates), premature ejaculation (SSRIs), gender dysphoria (hormone therapy monitoring: testosterone → polycythemia, estrogen → VTE risk), high suicide risk, paraphilic disorders (CBT, SSRI) Sleep disorders – insomnia (CBT-I first-line), narcolepsy (modafinil, sodium oxybate for cataplexy), obstructive sleep apnea (CPAP first-line), restless legs syndrome (iron if ferritin 75), REM sleep behavior disorder (prodrome of Parkinson's/Lewy body), zolpidem (complex sleep behaviors) Psychiatric emergencies – NMS (fever, rigidity, elevated CK, stop antipsychotic), serotonin syndrome (clonus, hyperreflexia, stop serotonergic drugs, cyproheptadine), acute dystonia (IM benztropine or diphenhydramine), akathisia, tardive dyskinesia (AIMS exam), lithium toxicity (hemodialysis if severe), clozapine agranulocytosis (ANC 500), valproate toxicity, hyperammonemia, carbamazepine rash (SJS), MAOI hypertensive crisis (phentolamine) High-yield clinical case questions (30 cases) Each question includes the correct answer and a clear, high-yield rationale. Updated for 2026. A+ verified. Perfect for GALEN NUR 253, mental health nursing, NCLEX, HESI, and ATI Mental Health exams.

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GALEN NUR 253 EXAM 2 STUDY GUIDE 2026: 300
QUESTIONS WITH ANSWERS & RATIONALES |
MENTAL HEALTH NURSING



# Table of Contents


| Section | Topic | Question Count |
|---------|-------|----------------|
| 1 | Substance Use Disorders (Alcohol, Opioids, Stimulants, Sedatives) |
50 |
| 2 | Crisis Intervention & Disaster Response | 25 |
| 3 | Suicide Prevention & Risk Assessment | 25 |
| 4 | Child & Adolescent Psychiatric Disorders (ADHD, Autism, Conduct
Disorder) | 40 |
| 5 | Older Adult Mental Health (Dementia, Delirium, Depression) | 35 |
| 6 | Family Violence, Abuse, & Trauma | 25 |
| 7 | Sexual Disorders & Gender Dysphoria | 20 |
| 8 | Sleep Disorders (Insomnia, Narcolepsy, Sleep Apnea) | 20 |
| 9 | Psychiatric Emergencies (Agitation, NMS, Serotonin Syndrome) |
30 |
| 10 | High-Yield Clinical Case Questions | 30 |
| **Total** | | **300** |

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# SECTION 1: Substance Use Disorders (Alcohol, Opioids, Stimulants,
Sedatives) – 50 Questions


**1. A patient with alcohol use disorder reports tremors, anxiety, and
nausea 6 hours after last drink. This is:**
A. Alcohol intoxication
B. Alcohol withdrawal (early)
C. Delirium tremens
D. Wernicke's encephalopathy


**Answer: B – Alcohol withdrawal (early)**
*Rationale:* Early withdrawal (6-12 hours): tremors, anxiety,
diaphoresis, nausea, insomnia. Delirium tremens (48-72 hours):
hallucinations, seizures, autonomic instability.


**2. Which medication is first-line for alcohol withdrawal to prevent
seizures and delirium tremens?**
A. Haloperidol
B. Benzodiazepines (lorazepam, chlordiazepoxide)
C. Baclofen

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D. Naltrexone


**Answer: B – Benzodiazepines**
*Rationale:* Benzodiazepines (chlordiazepoxide, lorazepam, diazepam)
are first-line for alcohol withdrawal (CIWA-Ar protocol). They reduce
seizure and DT risk.


**3. A patient with alcohol use disorder is started on disulfiram
(Antabuse). The nurse teaches that drinking alcohol will cause:**
A. Euphoria
B. Nausea, vomiting, flushing, hypotension (acetaldehyde buildup)
C. Sedation
D. No effect


**Answer: B – Disulfiram-ethanol reaction**
*Rationale:* Disulfiram inhibits aldehyde dehydrogenase →
acetaldehyde accumulation → flushing, N/V, hypotension, palpitations.
Can be severe.


**4. A patient with opioid use disorder is in withdrawal. Which
symptoms are expected?**
A. Diarrhea, vomiting, yawning, dilated pupils, piloerection
(goosebumps)
B. Sedation, miosis (pinpoint pupils), respiratory depression

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C. Seizures
D. Hallucinations


**Answer: A – Opioid withdrawal (flu-like, dilated pupils)**
*Rationale:* Opioid withdrawal: lacrimation, yawning, rhinorrhea,
dilated pupils, diarrhea, vomiting, muscle aches (not life-threatening but
very uncomfortable).


**5. Which medication is used for opioid withdrawal and maintenance
(reduces cravings, blocks euphoria)?**
A. Buprenorphine (partial agonist) or methadone (full agonist)
B. Naltrexone (antagonist)
C. Clonidine (for withdrawal symptoms)
D. All of the above


**Answer: D – All of the above**
*Rationale:* Opioid use disorder treatment: methadone/buprenorphine
(agonist therapy), naltrexone (antagonist), clonidine (symptom
management).


**6. A patient overdoses on heroin and is unresponsive with respiratory
rate of 4 breaths/min. The nurse should administer:**
A. Flumazenil
B. Naloxone (Narcan) IV/IM

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