Acute and Chronic inflammation MCQ
Regarding acute inflammation
a) Initial vasoconstriction is the result of histamine and nitric oxide
b) Stasis occurs due to vasodilatation and the larger caliber of vessels
c) Increased permeability leads to protein depleted plasma leaking into the tissue
d) Initial formation of endothelial gaps lasts for only 15-30 minutes
e) Cytokines (IL-1 and TNF) are responsible for the early permeability
Histamine is involved in acute inflammatory responses and is released from mast
cells. Which of the following statements is incorrect?
a) It is found in blood basophils, platelets and mast cells
b) It causes increased permeability of arterioles
c) It may be released by physical trauma
d) It causes constriction of large vessels
e) It acts on the microcirculation via H1 receptors
Complement
a) Proteins are usually stored in an active state in lysosomal molecules
b) Pathway is inhibited by C3 cleavage
c) C3 is the most abundant protein in the complement family
d) Activation by the classical pathway involves microbial surface antigens
e) Cobra venom activates the lectin pathway
Regarding mediators of inflammation
a) TNF is a chemokine with chemoattractant properties
b) TNF contributes to cachexia of disease
c) TNF and IL-1 are produced mainly by activated leukocytes
d) The systemic acute phase response is induced by MIP-1 and RANTES
chemokines
e) PAF causes vasodilation when expressed at high levels
Chronic inflammation is characterized by all of the below except
a) Tissue destruction
b) Angiogenesis
c) Infiltration with neutrophils
d) Fibrosis
e) Increased tissue concentration of lymphocytes
Regarding acute inflammation
a) Initial vasoconstriction is the result of histamine and nitric oxide
b) Stasis occurs due to vasodilatation and the larger caliber of vessels
c) Increased permeability leads to protein depleted plasma leaking into the tissue
d) Initial formation of endothelial gaps lasts for only 15-30 minutes
e) Cytokines (IL-1 and TNF) are responsible for the early permeability
Histamine is involved in acute inflammatory responses and is released from mast
cells. Which of the following statements is incorrect?
a) It is found in blood basophils, platelets and mast cells
b) It causes increased permeability of arterioles
c) It may be released by physical trauma
d) It causes constriction of large vessels
e) It acts on the microcirculation via H1 receptors
Complement
a) Proteins are usually stored in an active state in lysosomal molecules
b) Pathway is inhibited by C3 cleavage
c) C3 is the most abundant protein in the complement family
d) Activation by the classical pathway involves microbial surface antigens
e) Cobra venom activates the lectin pathway
Regarding mediators of inflammation
a) TNF is a chemokine with chemoattractant properties
b) TNF contributes to cachexia of disease
c) TNF and IL-1 are produced mainly by activated leukocytes
d) The systemic acute phase response is induced by MIP-1 and RANTES
chemokines
e) PAF causes vasodilation when expressed at high levels
Chronic inflammation is characterized by all of the below except
a) Tissue destruction
b) Angiogenesis
c) Infiltration with neutrophils
d) Fibrosis
e) Increased tissue concentration of lymphocytes
