General Pathology MCQs
Answers not sure 100%
Cell Injury
Change of Columnar Epithelium of the Bronchi
Consequences of Necrosis do not include: into Mature Squamous Epithelium is called:
a) Dystrophic Calcification a) Metaplasia
b) Resolution b) Dysplasia
c) Inflammatory Reaction c) Hyperplasia
d) Fibrosis d) Neoplasia
e) Increased Cellular Enzymes in the Blood e) Hypertrophy
The type of necrosis that occurs in Per Metastatic Calcification:
pancreatic tissue in Acute Pancreatitis is: a) Is due to hypercalcemia
a) Liquefaction b) Is due to hypocalcemia
b) Fat c) Occurs in Necrotic Tissue
c) Coagulation d) Occurs at sites of Chronic Inflammation
d) Gummatous e) Is due to malignancy
e) Fibrinoid
Which of the following is a feature of
Which type of Necrosis is most typically Irreversible Cell Injury:
associated with Pyogenic Infection: a) Glycogen stores are depleted
a) Fibrinoid Necrosis b) Cytoplasmic sodium increases
b) Enzymatic Fat Necrosis c) Nuclei undergo karyorrhexis
c) Coagulation Necrosis d) Intracellular pH diminishes
d) Caseous Necrosis e) Blebs form on cell membranes
e) Liquefaction Necrosis
Which of the following processes that occur in
The microscopic appearance of an increased the breast allows a mother to feed the
cell size of multiple cells in a tissue, due to infant:
an increase in the amount of cytoplasm, a) Stromal hypertrophy
with nuclei remaining uniform in size, is b) Epithelial dysplasia
best illustrated by: c) Steatocyte atrophy
a) The uterine myometrium in pregnancy d) Ductul epithelial metaplasia
b) The female breast at puberty e) Lobular hyperplasia
c) The liver following partial resection
d) The ovary following menopause An Amputated lower limb from a diabetic
e) The cervix with chronic inflammation patient showing black discoloration of the
skin and soft tissues with areas of yellowish
Following Myocardial Infarction due to exudates is characterized as:
Thrombosis in a Coronary Artery and a) Neoplasia
management by Streptokinase (a b) Gangrenous Necrosis
thrombocytic agent), which of the following c) Coagulopathy
is likely to happen in myocardium: d) Hemosiderosis
a) Apoptosis e) Gas gangrene
b) Free Radical Injury
c) Heterophagoctytosis
d) Squamous Metaplasia
e) Accumulation of Cytokeratins
1
, General Pathology MCQs
Answers not sure 100%
Focal fat necrosis, with flecks of chalky tan- Lipofuscin deposition is most likely to result
white material seen in the omentum is most from:
often associated with the following: a) Nuclear pyknosis
a) Gangrenous appendicitis b) Myocardial fiber hypertrophy
b) Chronic salpingitis c) Coagulative necrosis
c) Acute pancreatitis d) Autophagocytosis
d) Hepatitis e) Anaerobic glycolysis
e) Acute gastritis
In a 60 year old male, Gangrene of toes is most Which of the following is an Anti-Oxidant:
likely associated with: a) Glutathione Peroxidase
a) Diabetes Mellitus b) Catalase
b) Heart Failure c) Hydrogen peroxide
c) Blunt force trauma d) NADPH oxidase
d) AIDS e) Myeloperoxidase
e) Type III hypersensitivity reaction
Which of the following is the most likely
The presence of Columnar Epithelium with pathologic alteration following occlusion of
Goblet cells in the Lower Oesophagus is the left middle cerebral artery by a sterile
most consistent with: thrombus:
a) Dysplasia a) Cerebral softening from liquefactive necrosis
b) Hyperplasia b) Pale infarction with coagulative necrosis
c) Carcinoma c) Predominantly the loss of glial cells
d) Ischaemia d) Recovery of damaged neurons if the vascular
e) Metaplasia supply is re-established
e) Wet gangrene with secondary bacterial infection
Metaplasia is most closely associated with:
a) Hypercalcemia The action of putrefactive bacteria on necrotic
b) Necrosis tissue results in:
c) Chronic Irritation a) Coagulation
d) Diminished Blood Supply b) Infarction
e) Increased Workload c) Gangrene
d) Embolism
Which of the following processes explain the e) Caseation
appearance of Calcium deposition in
Tuberculous Lymph Nodes: Which of the following type of necrosis is most
a) Dystrophic calcification commonly associated with ischaemic injury:
b) Apoptosis a) Coagulation Necrosis
c) Hypercalcaemia b) Liquefaction Necrosis
d) Metastatic calcification c) Caseous Necrosis
e) Neoplastic change d) Fat Necrosis
e) Gangrenous Necrosis
2
, General Pathology MCQs
Answers not sure 100%
Enzymes involved in the inactivation of free Select the wrong statement. Apoptosis:
radicals include: a)Occurs in singles cells or in small cluster of cells
a) Superoxide dismutase b) Is programmed cell death
b) Vitamin E c) Is seen in toxic or viral hepatitis
c) Both A and B d) Appears cheesy in appearance
d) Neither A nor B e) Does not elicit an inflammatory reaction
e) -antitrypsin
Intracellular system(s) sensitive to cell injury
Calcium may play a role in cell injury by: is/are:
a) Causing ATP depletion a) Aerobic respiration
b) Activating phospholipases b) Maintenance of the integrity of cell membrane
c) Inducing autophagocytosis c) Synthesis of protein
d) Regulating pyknosis d) Integrity of genetic apparatus
e) Reducing intracellular pH e) All of the above
A common manifestation of sublethal cell injury Which of the following can undergo apoptosis:
(reversible injury) in organs such as the a) Cells infected with virus
heart and liver is: b) Cells with DNA damage
a) Glycogen accumulation c) Increased oxidant within the cell
b) Fatty change d) None of the above
c) Calcium deposition e) All of the above
d) Apoptosis
e) Deposition of melanin Apoptosis:
a) Massive necrosis
An area of keratinizing squamous epithelium b) Foreign body phagocytosis
lining a major bronchus is an example of: c) Lipoprotein synthesis
a) Heterotopia d) Programmed cell death
b) Metaplasia e) Wet gangrene
c) Dysplasia
d) Atrophy The following is true about hyperplasia except:
e) Neoplasia a) Can be physiological
b) Is a precancerous condition
Each of the following is an example of c) Is reversible
hyperplasia except: d) Is due to excess hormone stimulation
a) Enlargement of one kidney after surgical e) Can be associated with hypertrophy
removal of the other kidney
b) Changes in the thyroid gland in response to Early clumping of nuclear chromatin is most
increased demand for thyroid closely associated with:
hormones a) Reduced intracellular pH
c) Changes in breast tissue during pregnancy b) Increased intracellular pH
d) Enlargement of lymph nodes during a viral c) Denatured proteins and RNA loss
infection d) Decreased DNA synthesis
e) Enlargement of skeletal muscles after weight e) Release of lysosomal enzymes
training
3
, General Pathology MCQs
Answers not sure 100%
Digestion of tissue with soap formation and e) Gangrenous necrosis
calcification is characteristic of:
a) Coagulation Necrosis Dystrophic Calcification is most closely
b) Caseous Necrosis associated with:
c) Fibrinoid Necrosis a) Hypercalcemia
d) Liquefaction Necrosis b) Necrosis
e) Enzymatic Fat Necrosis c) Chronic irritation
d) Diminished blood supply
Which of the following is most likely to give rise e) Increased workload
to Metaplasia:
a) Tanning of the skin following sunlight exposure Deposition of Calcium in dead or dying tissue
b) Lactation following pregnancy is:
c) Vitamin A deficiency a) Dystrophic calcification
d) Acute Myocardial Infarction b) Metastatic calcification
e) Acute Tubular Necrosis c) Both A and B
d) Neither A nor B
Which of the following is deposited in
myocardium in advanced age: Which of the following types of necrosis is
a) Hemosidrin characterized by amorphous granular
b) Lipochrome debris:
c) Glycogen a) Coagulation Necrosis
d) Cholesterol b) Liquifaction Necrosis
e) Calcium Salts c) Caseous Necrosis
d) Fat Necrosis
Which of the following tissues is most likely to e) Gangrenous Necrosis
be least affected by Ischemia:
a) Skeletal muscle Hypertrophy is most closely associated with:
b) Small intestinal epithelium a) Hypercalcemia
c) Retina b) Necrosis
d) Myocardium c) Chronic Irritation
e) Hippocampus d) Diminished Blood Supply
e) Increased Work Load
An amputated foot of a diabetic will most likely
show: Which of the following is most susceptible to
a) Neoplasia liquefaction necrosis following ischemic
b) Gangrenous Necrosis injury:
c) Coagulopathy a) Pancreas
d) Hemosiderosis b) Liver
e) Caseation c) Spleen
d) Brain
Which of the following types of necrosis is e) Intestine
grossly opaque & "chalk" white:
a) Coagulation necrosis
b) Liquefaction
c) Caseous necrosis
d) Fat necrosis
4
Answers not sure 100%
Cell Injury
Change of Columnar Epithelium of the Bronchi
Consequences of Necrosis do not include: into Mature Squamous Epithelium is called:
a) Dystrophic Calcification a) Metaplasia
b) Resolution b) Dysplasia
c) Inflammatory Reaction c) Hyperplasia
d) Fibrosis d) Neoplasia
e) Increased Cellular Enzymes in the Blood e) Hypertrophy
The type of necrosis that occurs in Per Metastatic Calcification:
pancreatic tissue in Acute Pancreatitis is: a) Is due to hypercalcemia
a) Liquefaction b) Is due to hypocalcemia
b) Fat c) Occurs in Necrotic Tissue
c) Coagulation d) Occurs at sites of Chronic Inflammation
d) Gummatous e) Is due to malignancy
e) Fibrinoid
Which of the following is a feature of
Which type of Necrosis is most typically Irreversible Cell Injury:
associated with Pyogenic Infection: a) Glycogen stores are depleted
a) Fibrinoid Necrosis b) Cytoplasmic sodium increases
b) Enzymatic Fat Necrosis c) Nuclei undergo karyorrhexis
c) Coagulation Necrosis d) Intracellular pH diminishes
d) Caseous Necrosis e) Blebs form on cell membranes
e) Liquefaction Necrosis
Which of the following processes that occur in
The microscopic appearance of an increased the breast allows a mother to feed the
cell size of multiple cells in a tissue, due to infant:
an increase in the amount of cytoplasm, a) Stromal hypertrophy
with nuclei remaining uniform in size, is b) Epithelial dysplasia
best illustrated by: c) Steatocyte atrophy
a) The uterine myometrium in pregnancy d) Ductul epithelial metaplasia
b) The female breast at puberty e) Lobular hyperplasia
c) The liver following partial resection
d) The ovary following menopause An Amputated lower limb from a diabetic
e) The cervix with chronic inflammation patient showing black discoloration of the
skin and soft tissues with areas of yellowish
Following Myocardial Infarction due to exudates is characterized as:
Thrombosis in a Coronary Artery and a) Neoplasia
management by Streptokinase (a b) Gangrenous Necrosis
thrombocytic agent), which of the following c) Coagulopathy
is likely to happen in myocardium: d) Hemosiderosis
a) Apoptosis e) Gas gangrene
b) Free Radical Injury
c) Heterophagoctytosis
d) Squamous Metaplasia
e) Accumulation of Cytokeratins
1
, General Pathology MCQs
Answers not sure 100%
Focal fat necrosis, with flecks of chalky tan- Lipofuscin deposition is most likely to result
white material seen in the omentum is most from:
often associated with the following: a) Nuclear pyknosis
a) Gangrenous appendicitis b) Myocardial fiber hypertrophy
b) Chronic salpingitis c) Coagulative necrosis
c) Acute pancreatitis d) Autophagocytosis
d) Hepatitis e) Anaerobic glycolysis
e) Acute gastritis
In a 60 year old male, Gangrene of toes is most Which of the following is an Anti-Oxidant:
likely associated with: a) Glutathione Peroxidase
a) Diabetes Mellitus b) Catalase
b) Heart Failure c) Hydrogen peroxide
c) Blunt force trauma d) NADPH oxidase
d) AIDS e) Myeloperoxidase
e) Type III hypersensitivity reaction
Which of the following is the most likely
The presence of Columnar Epithelium with pathologic alteration following occlusion of
Goblet cells in the Lower Oesophagus is the left middle cerebral artery by a sterile
most consistent with: thrombus:
a) Dysplasia a) Cerebral softening from liquefactive necrosis
b) Hyperplasia b) Pale infarction with coagulative necrosis
c) Carcinoma c) Predominantly the loss of glial cells
d) Ischaemia d) Recovery of damaged neurons if the vascular
e) Metaplasia supply is re-established
e) Wet gangrene with secondary bacterial infection
Metaplasia is most closely associated with:
a) Hypercalcemia The action of putrefactive bacteria on necrotic
b) Necrosis tissue results in:
c) Chronic Irritation a) Coagulation
d) Diminished Blood Supply b) Infarction
e) Increased Workload c) Gangrene
d) Embolism
Which of the following processes explain the e) Caseation
appearance of Calcium deposition in
Tuberculous Lymph Nodes: Which of the following type of necrosis is most
a) Dystrophic calcification commonly associated with ischaemic injury:
b) Apoptosis a) Coagulation Necrosis
c) Hypercalcaemia b) Liquefaction Necrosis
d) Metastatic calcification c) Caseous Necrosis
e) Neoplastic change d) Fat Necrosis
e) Gangrenous Necrosis
2
, General Pathology MCQs
Answers not sure 100%
Enzymes involved in the inactivation of free Select the wrong statement. Apoptosis:
radicals include: a)Occurs in singles cells or in small cluster of cells
a) Superoxide dismutase b) Is programmed cell death
b) Vitamin E c) Is seen in toxic or viral hepatitis
c) Both A and B d) Appears cheesy in appearance
d) Neither A nor B e) Does not elicit an inflammatory reaction
e) -antitrypsin
Intracellular system(s) sensitive to cell injury
Calcium may play a role in cell injury by: is/are:
a) Causing ATP depletion a) Aerobic respiration
b) Activating phospholipases b) Maintenance of the integrity of cell membrane
c) Inducing autophagocytosis c) Synthesis of protein
d) Regulating pyknosis d) Integrity of genetic apparatus
e) Reducing intracellular pH e) All of the above
A common manifestation of sublethal cell injury Which of the following can undergo apoptosis:
(reversible injury) in organs such as the a) Cells infected with virus
heart and liver is: b) Cells with DNA damage
a) Glycogen accumulation c) Increased oxidant within the cell
b) Fatty change d) None of the above
c) Calcium deposition e) All of the above
d) Apoptosis
e) Deposition of melanin Apoptosis:
a) Massive necrosis
An area of keratinizing squamous epithelium b) Foreign body phagocytosis
lining a major bronchus is an example of: c) Lipoprotein synthesis
a) Heterotopia d) Programmed cell death
b) Metaplasia e) Wet gangrene
c) Dysplasia
d) Atrophy The following is true about hyperplasia except:
e) Neoplasia a) Can be physiological
b) Is a precancerous condition
Each of the following is an example of c) Is reversible
hyperplasia except: d) Is due to excess hormone stimulation
a) Enlargement of one kidney after surgical e) Can be associated with hypertrophy
removal of the other kidney
b) Changes in the thyroid gland in response to Early clumping of nuclear chromatin is most
increased demand for thyroid closely associated with:
hormones a) Reduced intracellular pH
c) Changes in breast tissue during pregnancy b) Increased intracellular pH
d) Enlargement of lymph nodes during a viral c) Denatured proteins and RNA loss
infection d) Decreased DNA synthesis
e) Enlargement of skeletal muscles after weight e) Release of lysosomal enzymes
training
3
, General Pathology MCQs
Answers not sure 100%
Digestion of tissue with soap formation and e) Gangrenous necrosis
calcification is characteristic of:
a) Coagulation Necrosis Dystrophic Calcification is most closely
b) Caseous Necrosis associated with:
c) Fibrinoid Necrosis a) Hypercalcemia
d) Liquefaction Necrosis b) Necrosis
e) Enzymatic Fat Necrosis c) Chronic irritation
d) Diminished blood supply
Which of the following is most likely to give rise e) Increased workload
to Metaplasia:
a) Tanning of the skin following sunlight exposure Deposition of Calcium in dead or dying tissue
b) Lactation following pregnancy is:
c) Vitamin A deficiency a) Dystrophic calcification
d) Acute Myocardial Infarction b) Metastatic calcification
e) Acute Tubular Necrosis c) Both A and B
d) Neither A nor B
Which of the following is deposited in
myocardium in advanced age: Which of the following types of necrosis is
a) Hemosidrin characterized by amorphous granular
b) Lipochrome debris:
c) Glycogen a) Coagulation Necrosis
d) Cholesterol b) Liquifaction Necrosis
e) Calcium Salts c) Caseous Necrosis
d) Fat Necrosis
Which of the following tissues is most likely to e) Gangrenous Necrosis
be least affected by Ischemia:
a) Skeletal muscle Hypertrophy is most closely associated with:
b) Small intestinal epithelium a) Hypercalcemia
c) Retina b) Necrosis
d) Myocardium c) Chronic Irritation
e) Hippocampus d) Diminished Blood Supply
e) Increased Work Load
An amputated foot of a diabetic will most likely
show: Which of the following is most susceptible to
a) Neoplasia liquefaction necrosis following ischemic
b) Gangrenous Necrosis injury:
c) Coagulopathy a) Pancreas
d) Hemosiderosis b) Liver
e) Caseation c) Spleen
d) Brain
Which of the following types of necrosis is e) Intestine
grossly opaque & "chalk" white:
a) Coagulation necrosis
b) Liquefaction
c) Caseous necrosis
d) Fat necrosis
4
