NSAIDs and Exercise-
Simplified Study Presentation
C re a te d b y a s tu d e n t - a t h l e t e , b as e d o n u n iv e rs i t y - l e v e l
c o u rs e wo rk
,What is inflammation…
…and why it exists?
Inflammation is a regulated
During exercise:
biological response Necessary for
tissue repair and Controlled inflammation
triggered by tissue damage, contributes to skeletal muscle
adaptation
mediated by lipid-derived adaptation
signaling molecules
(e.g., prostaglandins)
Mediated by eicosanoids (lipid mediators):
Prostaglandins are synthesized
from arachidonic acid
2
, Membrane lipids and arachidonic acid
Source 1 Release 2 Molecule Identity 3
Membrane phospholipids ▪ Arachidonic acid is released ▪ Arachidonic acid
serve as reservoirs of by phospholipase A₂ ▪ 20-carbon polyunsaturated
arachidonic acid ▪ Triggered by cellular fatty acid
damage or stimulus ▪ Precursor of eicosanoids
Pathway Entry 4 Products 5
▪ Once released, it enters ▪ Eicosanoids =
enzymatic pathways bioactive lipid
“Damaging”
▪ Including the mediators Stimulus
cyclooxygenase ▪ Prostaglandins
(COX) pathway are a subclass
of eicosanoids
3
Simplified Study Presentation
C re a te d b y a s tu d e n t - a t h l e t e , b as e d o n u n iv e rs i t y - l e v e l
c o u rs e wo rk
,What is inflammation…
…and why it exists?
Inflammation is a regulated
During exercise:
biological response Necessary for
tissue repair and Controlled inflammation
triggered by tissue damage, contributes to skeletal muscle
adaptation
mediated by lipid-derived adaptation
signaling molecules
(e.g., prostaglandins)
Mediated by eicosanoids (lipid mediators):
Prostaglandins are synthesized
from arachidonic acid
2
, Membrane lipids and arachidonic acid
Source 1 Release 2 Molecule Identity 3
Membrane phospholipids ▪ Arachidonic acid is released ▪ Arachidonic acid
serve as reservoirs of by phospholipase A₂ ▪ 20-carbon polyunsaturated
arachidonic acid ▪ Triggered by cellular fatty acid
damage or stimulus ▪ Precursor of eicosanoids
Pathway Entry 4 Products 5
▪ Once released, it enters ▪ Eicosanoids =
enzymatic pathways bioactive lipid
“Damaging”
▪ Including the mediators Stimulus
cyclooxygenase ▪ Prostaglandins
(COX) pathway are a subclass
of eicosanoids
3
