Antimicrobials and Anti-Infectives
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,Based on the University of Alabama Capstone College of Nursing curriculum,
NUR 521 Advanced Pharmacology Module 9 covers antimicrobial agents,
antibiotics, and anti-infective therapy. This guide provides comprehensive
Q&A with rationales to prepare you for your exam.
Part 1: Fundamentals of Antimicrobial Therapy
s s s s s
Question 1 s
The sdevelopment sof sa snew sinfection sas sa sresult sof sthe selimination sof snormal sflora
sby san santibiotic sis sreferred sto sas swhat?
A. sResistant sinfection
B. sSuperinfection
C. sNosocomial sinfection
D. sAllergic sreaction
Answer: sB s– sSuperinfection
Rationale: sAntibiotic stherapy scan sdestroy sthe snormal sflora sof sthe sbody, swhich
snormally sinhibits sthe sovergrowth sof sfungi sand syeast. sWhen snormal sflora sis
sdecreased, sthese sorganisms scan sovergrow sand scause sa snew sinfection, sor
ssuperinfection.
Question 2 s
A smicrobe sacquires santibiotic sresistance sby swhich smeans?
A. sDevelopment sof smedication sresistance sin sthe shost
B. sOver-riding sof sthe sminimum sbactericidal sconcentration
C. sIncorrect sdosing, swhich scontributes sto sribosome smutations
D. sTransfer sof sDNA scoding sto sother sbacteria
Answer: sD s– sTransfer sof sDNA scoding sto sother sbacteria
, Rationale: sAll salterations sin smicrobial sstructure sand sfunction sresult sfrom schanges
sin sthe smicrobial sgenome. sThe smicrobe, snot sthe shost, sbecomes smedication
sresistant. sGenetic schanges soccur seither sfrom sspontaneous smutation sor sfrom
sacquisition sof sDNA sthrough sconjugation swith s other sbacteria.
Question 3 s
The snurse sidentifies swhich shost sfactor sas sthe smost simportant swhen schoosing san
santimicrobial sdrug?
A. sAge
B. sCompetent simmune sfunction
C. sGenetic sheritage
D. sPrevious smedication sreactions
Answer: sB s– sCompetent simmune sfunction
Rationale: sTwo sfactors sare sunique sto santibiotic sselection: shost sdefenses sand sthe
ssite sof sinfection. sIt sis scritical sthat santibiotics sact ssynergistically swith sthe simmune
ssystem sto ssubdue sinfection. sOther shost sfactors s(age, sgenetic sheritage, sprevious
sdrug sreactions) sare simportant sfor sall smedication sselection.
Question 4 s
A snurse sremoves sa scentral sline saccess sdevice sonce sthe spatient sno slonger srequires
sintravenous s(IV) santibiotics. sThis saction sis san sexample sof swhich sstrategy sto
sprevent santimicrobial sresistance sestablished sby sthe sCDC?
A. sPreventing stransmission
B. sProper sdiagnosis
C. sPreventing sinfection
D. sPrudent santibiotic suse
Answer: sC s– sPreventing sinfection