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Blood Bank ASCP Exam 120+ Questions & Answers (2026) – Transfusion Medicine, Blood Components, Immunohematology (BB ASCP) – Medical Laboratory Science

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This document provides a comprehensive collection of over 120 Blood Bank ASCP exam questions with detailed and verified answers, covering essential topics in transfusion medicine and immunohematology. It includes core concepts such as donor eligibility criteria, blood component preparation and storage (RBCs, platelets, plasma, cryoprecipitate), infectious disease screening (HIV, HBsAg, syphilis), and compatibility testing procedures. The material is structured in a high-yield, exam-focused format with clinically relevant explanations. For example, as shown on page 2, the minimum acceptable hemoglobin level for blood donors is 12.5 g/dL, while subsequent sections explore donor deferral criteria, blood processing techniques, and laboratory testing methods such as ELISA and Western blot for infectious disease screening. In addition, the document offers in-depth coverage of red cell antigen systems (ABO, Rh, Kell, Duffy, Lewis), genotype and phenotype interpretation, antibody identification, and transfusion compatibility. It also addresses advanced topics such as storage conditions, expiration times, component handling protocols, and clinical decision-making in transfusion scenarios. Practical problem-solving questions involving Rh genetics, HLA typing, and antigen-antibody reactions further enhance understanding and exam readiness. This resource is ideal for students and professionals in Medical Laboratory Science (MLS), Medical Laboratory Technician (MLT), Clinical Laboratory Science, Hematology, and Biomedical Science programs. It is particularly valuable for individuals preparing for the ASCP Blood Bank (BB) certification exam, as well as laboratory professionals seeking to strengthen their knowledge in immunohematology and transfusion practices. The content aligns closely with standard textbooks such as Modern Blood Banking & Transfusion Practices by Denise Harmening and Technical Manual by AABB, making it an excellent supplementary study guide for mastering blood banking concepts and achieving certification success. Keywords: blood bank ASCP exam, transfusion medicine, immunohematology, blood components storage, donor eligibility criteria, ABO Rh blood groups, antibody identification, ELISA HIV testing, Western blot confirmation, platelet preparation storage, cryoprecipitate transfusion, HLA typing blood bank, laboratory hematology

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Blood Bank ASCP 2026 MOST
RECENT COMPREHENSIVE
QUESTIONS AND ANSWERS
|COMPLETE SOLUTIONS |A+
GRADED |100% CORRECT!!

The minimum hemoglobin concentration in a fingerstick from a male blood

donor is:




a. 12.0 g/dL (120 g/L)

b. 12.5 g/dL (125 g/L)

,c. 13.5 g/dL (13.5 g/L)


d. 15.0 g/dL (150 g/L) - 🧠 ANSWER ✔✔b. 12.5 g/dL (125 g/L)




All donors, regardless of sex, require a minimum hemoglobin of 12.5 g/dL

(125 g/L). The value must not be performed on an earlobe stick.

Which one of the following constitutes permanent rejection status of a

donor?




a. a tattoo 5 months previously

b. recent close contact with a patient with viral hepatitis

c. 2 units of blood transfused 4 months previously

d. confirmed positive test for HBsAg 10 years previously - 🧠 ANSWER

✔✔d. confirmed positive test for HBsAg 10 years previously




A positive rest for HbsAg at any time is an indefinite deferral.

A cause for permanent deferral of blood donation is:

,a. diabetes

b. residence in an endemic malaria region

c. history of jaundice of uncertain cause


d. history of therapeutic rabies vaccine. - 🧠 ANSWER ✔✔c. history of

jaundice of uncertain cause




Jaundice is a sign of liver impairment, which might be due to HBV or HCV.

Infection with HBV and HCV is a cause for indefinite deferral.

Below are the results of the history obtained from a prospective female

blood donor:




age: 16

temp: 99.0 degree F (37.2 ˚C)

Hct: 36%

history: tetanus toxoid immunization 1 week previously




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PRIVACY STATEMENT. ALL RIGHTS RESERVED

, How many of the above results excludes this donor from giving blood for a

routine transfusion?




a. none

b. 1

c. 2


d. 3 - 🧠 ANSWER ✔✔b. 1




The Hct must be >38%. A donor may be 16 unless state law differs.

Temperature must not exceed 99.5 degrees F/37.5˚C, blood pressure must

be <180mm Hg systolic and <100mm Hg diastolic, pulse 50-100 unless an

athlete (which can be lower). Toxoids and vaccines from synthetic or killed

sources have no deferral.

Prior to blood donation, the intended venipuncture site must be cleaned

with a scrub solution containing:




a. hypochlorite

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