PHARMACOLOGY EXAM 3
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, About This Guide
This guide is designed to help you focus your study efforts for Exam 3 in NUR 521
Advanced Pharmacology at the University of Alabama. Based on the course
description, NUR 521 covers "basic principles of pharmacology as they apply to
drug therapy across the lifespan" including drugs affecting the immune system,
anti-infectives, and related topics .
Exam 3 typically covers:
• Immunology Review (natural vs. acquired immunity)
• Vaccines and Immunizations
• Antibiotics (penicillins, cephalosporins, fluoroquinolones, etc.)
• Anti-infectives across the lifespan
Part 1: Immunity and Immunology Review
Key Concepts
Term Definition
Natural immunity Physical barriers (skin), phagocytic cells, natural killer cells; present before
(innate) exposure, responds nonspecifically
Specific acquired Responses occur only after exposure to a foreign substance; objective is to
immunity antigens
Antigens Foreign substances that induce specific immune responses
Cell-mediated
Targets attacked directly by cytolytic T cells and macrophages
immunity
Humoral immunity Immune responses mediated by antibodies
, Cells of the Immune System
Cell Type Function
B lymphocytes Produce antibodies; mediate humoral immunity; produced in bone marrow
Cytolytic T
Attack and kill target cells directly; mature in thymus
cells
Essential for antibody production; release factors for delayed-type hypersensitivity;
Helper T cells
activate cytolytic T cells; target of HIV
Macrophages Phagocytosis; activate T cells; final mediators of DTH; phagocytize antibody-tagged
Dendritic cells Antigen-presenting cells (but not scavengers)
Mediate immediate hypersensitivity; release histamine, heparin; concentrated in ski
Mast cells
tissues
Neutrophils Phagocytize bacteria; devour IgG-tagged cells; major contributors to inflammation
Attack helminths (parasitic worms) coated with IgE; contribute to tissue injury in
Eosinophils
hypersensitivity
Antibodies (Immunoglobulins)
Antibody Location/Function
Mucous membranes of GI tract and lungs; secretions; first-line defense; transferred via
IgA
breastmilk
IgD On surface of mature B cells; receptor for antigen recognition
Binds to mast cells; stimulates histamine release; causes allergy symptoms; binds to parasi
IgE
worms