Elsevier's MLS Examination Review Questions and Answers

Elsevier's MLS Examination Review
Questions and Answers
5.AAcquiredAsideroblasticAanemiaAmayAbeApresentAinAallAofAtheAfollowingAexcept:


a.AAlcoholism
b.ALeadApoisoning
c.AMalabsorption
d.AMyelodysplasticAsyndromesA-AAnswerA5.Ac.AGastrointestinalAdiseaseAmayAleadAtoAmalabsorp-
tion,AwhichAcouldApossiblyAaffectAironAabsorption.
AlcoholismAandAleadApoisoningAcanAleadAtoAaAsec-
ondaryAsideroblasticAanemia,AandAprimaryAsideroblasticAanemiaAmayAbeAseenAinAmyelodysplastic
syndromes,AsuchAasArefractoryAanemiaAwithAringedAsideroblastsA(RARS).


17.AParoxysmalAnocturnalAhemoglobinuriaAisAcharacterizedAbyAflowAcytometryAresultsAthatAare:


a.ANegativeAforACD55AandACD59
b.APositiveAforACD55AandACD59
c.ANegativeAforACD4AandACD8
d.APositiveAforAallAnormalACDAmarkersA-
AAnswerA17.Aa.ATheAPIGAAgeneAcodesAforAglycophosphatidylinosi-
tolA(GPI)-anchoredAproteins.AParoxysmalAnocturnal
hemoglobinuriaAshowsAaAmutationAinAtheAPIGA
gene,AwhichAresultsAinAdeficienciesAinAGPIAproteins,
indicatedAbyAaAnegativeACD55AandACD59.


19.AWhichAofAtheAfollowingAdisordersAisAnotAclassifiedAasAaAmicroangiopathicAhemolyticAanemia?


a.ADisseminatedAintravascularAcoagulation
b.AHemolyticAuremicAsyndrome
c.ATraumaticAcardiacAhemolyticAanemia
d.AThromboticAthrombocytopenicApurpuraA-AAnswerA19.Ac.

,20.AAApreviouslyAhealthyA36-year-
oldAwomanAwithAvisitedAherAphysicianAbecauseAofAaAsuddenAonsetAofAeasyAbruisingAandAbleeding.A
OfAtheAfollowing,AwhichAisAthe
mostAlikelyAcauseAofAherAlaboratoryAresults?
WBCA10.5AxA109/LA
RBCA3.0AxA1012/LA
HgbA8.0Ag/dL
HctA25.0%
MCVA83AfL
MCHCA32%
PlateletsA18AxA109/L
MCHA26Apg
Differential:ANormalAWBCsAwithAmoderate
schistocytesAandApolychromasia
PT:A12.8Aseconds,AaPTT:A34Aseconds


a.ASickleAcellAanemia
b.AChronicAmyelogenousAleukemia
c.ADisseminatedAintravascularAcoagulation
d.AThromboticAthrombocytopenicApurpuraA-
AAnswerA20.Ad.AThromboticAthrombocytopenicApurpuraA(TTP)AisAtheAmostAlikelyAcauseAofAtheAlaborat
oryAresults,
becauseAitAisAconsistentAwithAtheAanemiaAandAthrombocytopeniaAwithAtheApresenceAofAschistocytes.A
TheApatientAisAexhibitingAnormalAcoagulationAresults,AwhichAwouldAbeAincreasedAin
disseminatedAintravascularAcoagulationA(DIC).


31.AAA36-year-
oldAmaleApatientAhasAaACBCAperformedAasApartAofAaAroutineAworkAphysical.ATheAWBCAcountAwasA6
.5A109/LAwithAaAdifferentialAcountAofA48%Aneutro-
phils,A40%Alymphocytes,A8%Amonocytes,A3%Aeosinophils,AandA1%Abasophils.ATheAmajorityAofAtheA
neutrophilsAwereAmatureAbutAhyposegmented,AshowingAbandlikeAorAsingleAnuclei.AWhatAdisorderAwo
uldAbe
suspected?


a.AAlder-ReillyAanomaly
b.ALeukocyteAadhesionAdeficiency
c.APelger-HuetAanomaly

, d.AReedASternbergAsyndromeA-AAnswerA31.Ac.AThisAisAconsistentAwithAPelger-HuetAanomaly,Awhich
isAcharacterizedAbyAmatureAneutrophils,AbutAhyposegmentationAinAtheAmajorityAofAneutrophils.AAlder
-
ReillyAanomalyAfeaturesAabnormalAgranulation,AleukocyteAadhesionAdeficiencyAshowsArelativelyAnorm
alAlookingAbutAfunctionallyAabnormal
neutrophils.


32.AAA38-year-oldAmaleApatientAhasAtheAfollowingACBCAresults:
WBC:A32.5A109/L
HctA48.0%
HgbA16.0A
RBC:A5.50A1012/L
Platelet:A225A109/L
Differential:A49%Asegmented
neutrophils,A9%Abands,A25%
lymphocytes,A9%Amonocytes,A1%
eosinophils,A4%Ametamyelocytes,A3%
myelocytes;ARBCAandAplateletAmorphology
appearAnormal.AWhichAofAtheAfollowingAconditionsAisAtheAmostAlikelyAcauseAofAtheseAresults?


a.ABacterialAinfection
b.ACML
c.ARefractoryAanemia
d.AViralAinfectionA-
AAnswerA32.Aa.AAcuteAbacterialAinfectionAisAtheAmostAlikelyAcauseAofAtheseAresults,AwithAanAelevat
edAwhiteAbloodAcell
countAandAshiftAtoAtheAleft.


33.AWhichAofAtheAfollowingAcytochemicalAstainsAisAbestAusedAtoAdistinguishAcellsAofAmonocyticAorigi
n?


a.Aa-NaphthylAacetateAesterase
b.ANaphtholAAS-DAchloroacetateAesterase
c.AMyeloperoxidase