SAMPLEX – MIDTERMS [Lesson 1-7]
1. Clinical description of families with hemophilia was first d. Chromatin
published by year?
a. 1802 10. Glycocalyx is primarily composed of glycoproteins
b. 1905 including all of the following factors except?
c. 1803 a. Factor V
d. 1913 b. Factor VIII
c. Factor I
2. Gave the description of the two male siblings who died d. Factor III
because of excessive bleeding after circumcision.
a. Moises Maimonides 11. All of the following are true regarding prostacyclin
b. Schonlein except?
c. Paul Morawitz a. Stimulates vasoconstriction
d. Lee & White b. Inhibits platelet activation
c. Anticoagulant
3. Process of platelet release into the bone marrow sinus d. Blood vessel product
a. Endomitosis
b. Megakaryopoiesis 12. All of the following are true regarding endothelial cells?
c. Mitosis a. Plays a role in coagulation and inflammation
d. Platelet Shedding b. Contains connective tissues such as collagen
and elastin.
4. Platelet factor that accelerates prothrombin conversion c. Associated with proteoglycan heparin sulfate
to thrombin? d. AOTA
a. PF 1
b. PF 2 13. All of the following are regulator proteins except
c. PF 3 a. Anti-thrombin III
d. PF 4 b. A-2 antiplamin
c. A-2 macroglobulin
5. The site for platelet cyclooxygenase and of prostaglandin d. TPA
synthesis can be found in?
a. Membranous system 14. Which of the following statement is incorrect?
b. Sol gel zone a. Endothelium procoagulant property
c. Peripheral zone involves secretion of nitric oxide
d. Organelle zone b. Damage endothelium exposes tissue factor on
cell membrane
6. All of the following are alpha granules except? c. vWF is secreted by endothelium to
a. Fibrinogen subendothelium
b. Serotonin d. Intact endothelium maintains thrombomodulin
c. Factor V that is associated with protein C activation
d. vWF
15. All of the following conditions can be associated with
7. All of the following are true regarding megakaryopoiesis hypocoagulation except?
except? a. Hemophilia
a. The first stage can be seen under light b. Hemorrhage
microscope c. Malignancies
b. Takes place in the bone marrow d. vWD
c. Needed growth factors for differentiation and
maturation 16. Condition of uncontrolled thrombosis due to uncontrolled
d. NOTA formation of thrombi in the vascular system occluding
vessels and depriving organs of blood.
8. All of the following are true regarding platelet except? a. Bleeding
a. Anucleated b. Hypocoagulation
b. MPV 80-100 FL c. a and b
c. Very granular d. Neither of the following
d. Lavender and granular under Wright-stained
wedge preparation 17. The platelet rolling and clinging to nonplatelet surface
is?
9. The best point of difference to distinguish MK I to MKIII? a. Reversible
a. Granules b. Irreversible
b. Mitosis c. Either of the following
c. DMS d. Neither of the following
CRA | 1 of 5
, Hematology II | SAMPLEX - Midterms
28. In direct method of platelet counting, platelets are
18. Platelet secretion is important because? counted in a hemocytometer as in 5 squares of the
a. It sustains further coagulation central square and four corner large squares.
b. It activates Intrinsic pathway a. The statement is correct
c. It activates fibrinolysis b. The statement is wrong
d. Neither of the following is correct c. Either of the following is correct
d. Neither of the following is correct
19. All of the following sustains vasoconstriction except?
a. Epinephrine 29. In platelet adhesiveness test the adhesiveness may be
b. Serotonin measured in vitro by their ability to adhere on glass
c. a and b surfaces. One of the methods that can used in this test is
d. Neither of the following Salzman method.
a. First statement is correct, second statement is
20. Fibrinolysis occurs following the release of tissue? wrong.
a. t-PA b. First statement is wrong, second statement is
b. TAFI correct
c. PAI-1 c. Neither of the statement is wrong
d. PAI-2 d. Either of the statement is correct
21. Hemostasis is a complex process that? 30. The negative pressure method, wherein trauma is
a. Produces clot to stop the bleeding created by means of suction cups applied to the skin, is
b. Keeps the clot confined one of the methods that can be used under?
c. Dissolves the clot as the wound heals a. Capillary fragility test
d. All of the following b. Platelet Factor 3 availability Test
c. Platelet aggregation test
22. Which of the following is incorrectly match? d. Clot retraction test
a. Canalicular system – Pathway for granules
b. Sol-gel zone – Microtubles and microfilaments 31. In coagulation cascade enzyme precursors are called?
c. Active process – ADPase and nitric oxide a. Serine protease
d. Passive process – Tissue plasminogen b. Transglutaminase
activator c. Zymogen
d. Transaminase
23. Which of the following is incorrectly match?
a. Vasoconstriction – Vessel of smooth muscles 32. Principal site of coagulation factor synthesis?
b. Platelet adhesion – Exposed subendothelium a. Liver
connective tissue b. Kidney
c. Platelet aggregation – Platelet to platelet c. Spleen
d. Fibrin plug formation – Stabilization of d. Bone marrow
factor XIII
33. All of the following are other names of High molecular
24. Platelet stimulating agents for platelet aggregation weight kininogen except?
include/s? a. Fletcher factor
a. Collagen b. William factor
b. ADP c. Flaujeac factor
c. Epinephrine d. Fitzgerald factor
d. All of the following
34. Christmas factor is preferably called?
25. Test that reflects quality of platelets, number of a. Plasma thromboplastin component
fibrinogen, fibrinolytic activity and packed red blood b. Plasma thromboplastin antecedent
cells? c. Antihemophilic factor C
a. Clot retraction d. Platelet cofactor 2
b. Platelet Adhesion
c. a and b 35. Molecule that activates extrinsic pathway?
d. Neither of the following a. Tissue Thromboplastin
b. Factor IV
26. Methods of bleeding time include all of the following c. PK
except? d. Tissue thrombomodulin
a. Coply Lalitch Method
b. Adelson-Crosby method 36. All of the following are true regarding fibrinogen group
c. Duke’s method except?
d. Fonio’s method a. Composed of fibrinogen, labile factor.
antihemophilic factor, and stabilizing factor
27. Prolonged bleeding time may be seen in? b. Calcium dependent
a. Scurvy c. Vitamin K independent
b. Severe anemia d. Seen in serum
c. a and b
d. Either of the following 37. A medical technologist extracted blood in ICU around 5
in the morning using red top, and run the specimen
CRA | 2 of 5
, Hematology II | SAMPLEX - Midterms
around 6 am, what are the expected coagulation factor c. aPTT
to be consumed? d. Mixing study
a. Fibrinogen group
b. Prothrombin group except prothrombin 45. Mixing studies are used to follow up to abnormal PT or
c. Contact group APTT, the test is repeated on 1:1 mixture of patients’
d. a and b plasma & normal plasma. If patient has factor deficiency,
time will be corrected because normal plasma supplies
38. A specimen for coagulation collected in an extreme cold missing factor.
temperature are expected to? a. First statement is correct, second statement is
a. Activate labile factor and antihemophilic factor wrong
b. Activate proconvertin and plasma b. First statement is wrong, second statement is
thromboplastin antecedent correct
c. Activate proconvertin and plasma c. Either of the statement is wrong
thromboplastin component d. Neither of the statement is wrong
d. Consume fibrinogen group
46. After mixing study the patient’s specimen results are still
39. Specimen for coagulation test that is not process prolonged for all the substitute, Specific factor inhibitor is
immediately may lead to depletion of factors? considered, if Bethesda assay is used which of the
a. Factor VII and XI following might be detected?
b. Factor V and VIII a. Lupus anticoagulant titer
c. Factor I, V, VIII and XIII b. Factor VIII inhibitor titer
d. Factor II, VII, IX, X c. Factor V deficiency
d. Protein S deficiency
40. Coagulation laboratory tests are drawn on a 47-year-old
woman with the recent diagnosis of an autoimmune 47. Final stage in coagulation?
disease. The physician ordered a 1:1 mixing study after a. Fibrinolysis
the original results revealed a prolonged activated partial b. Secondary hemostasis
thromboplastin time (aPTT). Patient aPTT: 51 s c. D dimer formation
(reference range 38 - 42 s), Immediate 1:1 aPTT mixing d. Primary hemostasis
study: 50 s (after mixing study) Which of the following do
these laboratory results suggest? 48. Zymogen form of plasminogen?
a. Vitamin K deficiency a. Plasmin
b. Presence of inhibitor b. t-PA
c. Factor VII deficiency c. Fibrin
d. Factor VIII deficiency d. Neither of the following
41. A newly registered medical technologist performed 49. Endogenous source of plasminogen activator?
mixing study on a patient that is experiencing bleeding a. Streptokinase
for a week, Laboratory result shows: Patient aPTT: 55 s b. Tissue plasminogen activator
(reference range 38 - 42 s), PT: 12 s (reference range c. Transamidase
13-15 s), Substitution tests results shows: Patient’s d. Tissue plasminogen activator inhibitor
plasma + Adsorbed plasma: Corrected, Patient’s plasma
+ Fresh Serum: Corrected. Which of the following do 50. Exogenous source of plasminogen activator?
these laboratory results suggest? a. Streptokinase
a. Factor XII deficiency b. Tissue plasminogen activator
b. Factor XI deficiency c. Transamidase
c. Factor II deficiency d. Tissue plasminogen activator inhibitor
d. Factor VIII deficiency
51. Primary inhibitor of fibrinolytic system?
42. Prolonged aPTT and PT test may be due to deficiency in a. Protein C
coagulation factor? b. Protein S
a. Contact factor c. a2-antiplasmin
b. Fibrinogen d. a2-macroglobulin
c. Proconvertin
d. Plasma thromboplastic antecedent 52. All of the following are true regarding plasminogen
except?
43. A patient was admitted due to bleeding tendency, a. a glycoprotein
medical history shows recent cardiac bypass surgery, b. synthesized in the kidney
which test can be used to detect the presence of c. increase concentration associated in
heparin? inflammation
a. TT d. AOTA
b. Reptilase time
c. aPTT 53. Thrombin-Activatable Fibrinolysis Inhibitor is activated by
d. All of the following a serine protease; its activation helps in down regulating
fibrinolysis.
44. Patient undergoing anticoagulant therapy are best a. First statement is correct, second statement is
monitored using? wrong
a. INR b. First statement is wrong, second statement is
b. PT correct
CRA | 3 of 5
1. Clinical description of families with hemophilia was first d. Chromatin
published by year?
a. 1802 10. Glycocalyx is primarily composed of glycoproteins
b. 1905 including all of the following factors except?
c. 1803 a. Factor V
d. 1913 b. Factor VIII
c. Factor I
2. Gave the description of the two male siblings who died d. Factor III
because of excessive bleeding after circumcision.
a. Moises Maimonides 11. All of the following are true regarding prostacyclin
b. Schonlein except?
c. Paul Morawitz a. Stimulates vasoconstriction
d. Lee & White b. Inhibits platelet activation
c. Anticoagulant
3. Process of platelet release into the bone marrow sinus d. Blood vessel product
a. Endomitosis
b. Megakaryopoiesis 12. All of the following are true regarding endothelial cells?
c. Mitosis a. Plays a role in coagulation and inflammation
d. Platelet Shedding b. Contains connective tissues such as collagen
and elastin.
4. Platelet factor that accelerates prothrombin conversion c. Associated with proteoglycan heparin sulfate
to thrombin? d. AOTA
a. PF 1
b. PF 2 13. All of the following are regulator proteins except
c. PF 3 a. Anti-thrombin III
d. PF 4 b. A-2 antiplamin
c. A-2 macroglobulin
5. The site for platelet cyclooxygenase and of prostaglandin d. TPA
synthesis can be found in?
a. Membranous system 14. Which of the following statement is incorrect?
b. Sol gel zone a. Endothelium procoagulant property
c. Peripheral zone involves secretion of nitric oxide
d. Organelle zone b. Damage endothelium exposes tissue factor on
cell membrane
6. All of the following are alpha granules except? c. vWF is secreted by endothelium to
a. Fibrinogen subendothelium
b. Serotonin d. Intact endothelium maintains thrombomodulin
c. Factor V that is associated with protein C activation
d. vWF
15. All of the following conditions can be associated with
7. All of the following are true regarding megakaryopoiesis hypocoagulation except?
except? a. Hemophilia
a. The first stage can be seen under light b. Hemorrhage
microscope c. Malignancies
b. Takes place in the bone marrow d. vWD
c. Needed growth factors for differentiation and
maturation 16. Condition of uncontrolled thrombosis due to uncontrolled
d. NOTA formation of thrombi in the vascular system occluding
vessels and depriving organs of blood.
8. All of the following are true regarding platelet except? a. Bleeding
a. Anucleated b. Hypocoagulation
b. MPV 80-100 FL c. a and b
c. Very granular d. Neither of the following
d. Lavender and granular under Wright-stained
wedge preparation 17. The platelet rolling and clinging to nonplatelet surface
is?
9. The best point of difference to distinguish MK I to MKIII? a. Reversible
a. Granules b. Irreversible
b. Mitosis c. Either of the following
c. DMS d. Neither of the following
CRA | 1 of 5
, Hematology II | SAMPLEX - Midterms
28. In direct method of platelet counting, platelets are
18. Platelet secretion is important because? counted in a hemocytometer as in 5 squares of the
a. It sustains further coagulation central square and four corner large squares.
b. It activates Intrinsic pathway a. The statement is correct
c. It activates fibrinolysis b. The statement is wrong
d. Neither of the following is correct c. Either of the following is correct
d. Neither of the following is correct
19. All of the following sustains vasoconstriction except?
a. Epinephrine 29. In platelet adhesiveness test the adhesiveness may be
b. Serotonin measured in vitro by their ability to adhere on glass
c. a and b surfaces. One of the methods that can used in this test is
d. Neither of the following Salzman method.
a. First statement is correct, second statement is
20. Fibrinolysis occurs following the release of tissue? wrong.
a. t-PA b. First statement is wrong, second statement is
b. TAFI correct
c. PAI-1 c. Neither of the statement is wrong
d. PAI-2 d. Either of the statement is correct
21. Hemostasis is a complex process that? 30. The negative pressure method, wherein trauma is
a. Produces clot to stop the bleeding created by means of suction cups applied to the skin, is
b. Keeps the clot confined one of the methods that can be used under?
c. Dissolves the clot as the wound heals a. Capillary fragility test
d. All of the following b. Platelet Factor 3 availability Test
c. Platelet aggregation test
22. Which of the following is incorrectly match? d. Clot retraction test
a. Canalicular system – Pathway for granules
b. Sol-gel zone – Microtubles and microfilaments 31. In coagulation cascade enzyme precursors are called?
c. Active process – ADPase and nitric oxide a. Serine protease
d. Passive process – Tissue plasminogen b. Transglutaminase
activator c. Zymogen
d. Transaminase
23. Which of the following is incorrectly match?
a. Vasoconstriction – Vessel of smooth muscles 32. Principal site of coagulation factor synthesis?
b. Platelet adhesion – Exposed subendothelium a. Liver
connective tissue b. Kidney
c. Platelet aggregation – Platelet to platelet c. Spleen
d. Fibrin plug formation – Stabilization of d. Bone marrow
factor XIII
33. All of the following are other names of High molecular
24. Platelet stimulating agents for platelet aggregation weight kininogen except?
include/s? a. Fletcher factor
a. Collagen b. William factor
b. ADP c. Flaujeac factor
c. Epinephrine d. Fitzgerald factor
d. All of the following
34. Christmas factor is preferably called?
25. Test that reflects quality of platelets, number of a. Plasma thromboplastin component
fibrinogen, fibrinolytic activity and packed red blood b. Plasma thromboplastin antecedent
cells? c. Antihemophilic factor C
a. Clot retraction d. Platelet cofactor 2
b. Platelet Adhesion
c. a and b 35. Molecule that activates extrinsic pathway?
d. Neither of the following a. Tissue Thromboplastin
b. Factor IV
26. Methods of bleeding time include all of the following c. PK
except? d. Tissue thrombomodulin
a. Coply Lalitch Method
b. Adelson-Crosby method 36. All of the following are true regarding fibrinogen group
c. Duke’s method except?
d. Fonio’s method a. Composed of fibrinogen, labile factor.
antihemophilic factor, and stabilizing factor
27. Prolonged bleeding time may be seen in? b. Calcium dependent
a. Scurvy c. Vitamin K independent
b. Severe anemia d. Seen in serum
c. a and b
d. Either of the following 37. A medical technologist extracted blood in ICU around 5
in the morning using red top, and run the specimen
CRA | 2 of 5
, Hematology II | SAMPLEX - Midterms
around 6 am, what are the expected coagulation factor c. aPTT
to be consumed? d. Mixing study
a. Fibrinogen group
b. Prothrombin group except prothrombin 45. Mixing studies are used to follow up to abnormal PT or
c. Contact group APTT, the test is repeated on 1:1 mixture of patients’
d. a and b plasma & normal plasma. If patient has factor deficiency,
time will be corrected because normal plasma supplies
38. A specimen for coagulation collected in an extreme cold missing factor.
temperature are expected to? a. First statement is correct, second statement is
a. Activate labile factor and antihemophilic factor wrong
b. Activate proconvertin and plasma b. First statement is wrong, second statement is
thromboplastin antecedent correct
c. Activate proconvertin and plasma c. Either of the statement is wrong
thromboplastin component d. Neither of the statement is wrong
d. Consume fibrinogen group
46. After mixing study the patient’s specimen results are still
39. Specimen for coagulation test that is not process prolonged for all the substitute, Specific factor inhibitor is
immediately may lead to depletion of factors? considered, if Bethesda assay is used which of the
a. Factor VII and XI following might be detected?
b. Factor V and VIII a. Lupus anticoagulant titer
c. Factor I, V, VIII and XIII b. Factor VIII inhibitor titer
d. Factor II, VII, IX, X c. Factor V deficiency
d. Protein S deficiency
40. Coagulation laboratory tests are drawn on a 47-year-old
woman with the recent diagnosis of an autoimmune 47. Final stage in coagulation?
disease. The physician ordered a 1:1 mixing study after a. Fibrinolysis
the original results revealed a prolonged activated partial b. Secondary hemostasis
thromboplastin time (aPTT). Patient aPTT: 51 s c. D dimer formation
(reference range 38 - 42 s), Immediate 1:1 aPTT mixing d. Primary hemostasis
study: 50 s (after mixing study) Which of the following do
these laboratory results suggest? 48. Zymogen form of plasminogen?
a. Vitamin K deficiency a. Plasmin
b. Presence of inhibitor b. t-PA
c. Factor VII deficiency c. Fibrin
d. Factor VIII deficiency d. Neither of the following
41. A newly registered medical technologist performed 49. Endogenous source of plasminogen activator?
mixing study on a patient that is experiencing bleeding a. Streptokinase
for a week, Laboratory result shows: Patient aPTT: 55 s b. Tissue plasminogen activator
(reference range 38 - 42 s), PT: 12 s (reference range c. Transamidase
13-15 s), Substitution tests results shows: Patient’s d. Tissue plasminogen activator inhibitor
plasma + Adsorbed plasma: Corrected, Patient’s plasma
+ Fresh Serum: Corrected. Which of the following do 50. Exogenous source of plasminogen activator?
these laboratory results suggest? a. Streptokinase
a. Factor XII deficiency b. Tissue plasminogen activator
b. Factor XI deficiency c. Transamidase
c. Factor II deficiency d. Tissue plasminogen activator inhibitor
d. Factor VIII deficiency
51. Primary inhibitor of fibrinolytic system?
42. Prolonged aPTT and PT test may be due to deficiency in a. Protein C
coagulation factor? b. Protein S
a. Contact factor c. a2-antiplasmin
b. Fibrinogen d. a2-macroglobulin
c. Proconvertin
d. Plasma thromboplastic antecedent 52. All of the following are true regarding plasminogen
except?
43. A patient was admitted due to bleeding tendency, a. a glycoprotein
medical history shows recent cardiac bypass surgery, b. synthesized in the kidney
which test can be used to detect the presence of c. increase concentration associated in
heparin? inflammation
a. TT d. AOTA
b. Reptilase time
c. aPTT 53. Thrombin-Activatable Fibrinolysis Inhibitor is activated by
d. All of the following a serine protease; its activation helps in down regulating
fibrinolysis.
44. Patient undergoing anticoagulant therapy are best a. First statement is correct, second statement is
monitored using? wrong
a. INR b. First statement is wrong, second statement is
b. PT correct
CRA | 3 of 5
