MSN 671 Module 3 Exam UPDATED ACTUAL
QUESTIONS AND CORRECT ANSWERS
Ligand-gated ion channels - CORRECT ANSWER Activated by the binding of a
neurotransmitter, drug, or hormone.
Voltage-sensitive ion channels - CORRECT ANSWER Activated by changes in
membrane voltage or charge.
Ionotropic receptors - CORRECT ANSWER Another name for ligand-gated ion
channels.
Clinical relevance of ligand-gated vs voltage-sensitive channels - CORRECT
ANSWER LGICs → rapid effects (e.g., benzodiazepines, ketamine); VSSCs/VSCCs
→ anticonvulsants, mood stabilizers, analgesics.
Dual role of ligand-gated ion channels - CORRECT ANSWER They act as both
receptors and ion channels.
Structure of LGICs - CORRECT ANSWER Several subunits arranged around an ion
channel with binding sites for NTs, drugs, ions, and allosteric modulators.
Pentameric receptors - CORRECT ANSWER Receptors with 5 subunits.
Tetrameric receptors - CORRECT ANSWER Receptors with 4 subunits + re-entrant
loop.
Examples of pentameric receptors - CORRECT ANSWER GABAA_AA, Nicotinic
acetylcholine receptor (nAChR), 5-HT3, Glycine receptor.
Examples of tetrameric receptors - CORRECT ANSWER AMPA, NMDA, Kainate
(glutamate receptors).
QUESTIONS AND CORRECT ANSWERS
Ligand-gated ion channels - CORRECT ANSWER Activated by the binding of a
neurotransmitter, drug, or hormone.
Voltage-sensitive ion channels - CORRECT ANSWER Activated by changes in
membrane voltage or charge.
Ionotropic receptors - CORRECT ANSWER Another name for ligand-gated ion
channels.
Clinical relevance of ligand-gated vs voltage-sensitive channels - CORRECT
ANSWER LGICs → rapid effects (e.g., benzodiazepines, ketamine); VSSCs/VSCCs
→ anticonvulsants, mood stabilizers, analgesics.
Dual role of ligand-gated ion channels - CORRECT ANSWER They act as both
receptors and ion channels.
Structure of LGICs - CORRECT ANSWER Several subunits arranged around an ion
channel with binding sites for NTs, drugs, ions, and allosteric modulators.
Pentameric receptors - CORRECT ANSWER Receptors with 5 subunits.
Tetrameric receptors - CORRECT ANSWER Receptors with 4 subunits + re-entrant
loop.
Examples of pentameric receptors - CORRECT ANSWER GABAA_AA, Nicotinic
acetylcholine receptor (nAChR), 5-HT3, Glycine receptor.
Examples of tetrameric receptors - CORRECT ANSWER AMPA, NMDA, Kainate
(glutamate receptors).
