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,HIV EIA (3rd generation immunoassay) - Answer: can use
urine, saliva, or serum (most accurate), need to wait until 12
weeks post exposure to see antibodies, >99% accurate
4th generation immunoassay- "gold standard"
measures P24 antigen
can test 10 days post exposure
Mast cell - Answer: Cellular bags of granules located in loose
connective tisssue close to blood vessels. Activation initiates
inflammatory process.
Histamine - Answer: Causes vasodilation, increases vascular
permeability, increases blood flow to the site of injury- causes
erythema and swelling.
Cytokines - Answer: Soluble factors that contribute to the
regulation of innate or adaptive resistance by affecting other
neighboring cells. Can be pro-inflammatory or anti-
,inflammatory. Can react quickly or be more delayed.
Leukotrines - Answer: Released when mast cells degranulate,
prolong the inflammatory process. Cause vasodilation, attract
neutrophils, monocytes, and eosinophils.target of inhibition
for singular.
Prostaglandins - Answer: Released when mast cells
degranulate, are produced by the arachidonic pathway. Cause
vasodilation, platelet aggregation at site of injury, pain, and
fever.
Chemotactic factors - Answer: Biochemical substance that
attracts leukocyte to the site of inflammation
Neutrophils - Answer: Predominant leukocyte at work during
the early stages of acute inflammation
Monocytes - Answer: Become macrophages when entering
, the tissue, responsible for presenting antigens to the CD4 cell
which triggers T-cell immunity and B-cell immunity.
Releases additional cytokines IL1, IL6, TNF.
Cytokine IL1 function - Answer: Causes fever, activates
phagocytes & lymphocytes and also increases the release of
IL6a
Cytokine IL6 function - Answer: Stimulates production of
acute phase reactants and promotes growth and stimulation
of RBCs
Cytokine TNF function - Answer: Causes fever, increases
synthesis of proinflammatory proteins by liver, causes muscle
wasting, induces thrombosis
Cytokine growth factor function - Answer: Promotes
production and maturation of neutrophils