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,T3 and T4 functions - Answer: - maintenance of muscle tone
- skeletal muscle maturation
- antagonization of insulin
- regulation of cellular metabolism
- promotion of production of heat
- maintenance of cardiac output, contraction and rate
- maintenance of GI secretion
- assistance w/ cardiac mobilization
- stimulation of lipid metab
- free fatty acid release
- cholesterol synthesis
- RBC prod
- regulates bdy heat
- affects repiratory rate & O2 utilization
thyroid hormone effects on the heart - Answer: - production
of contractile protein a-myosin is stim by T3
- T3 also stim production of sacrolemma ion pumps & B-
adrengeric receptors
,Hyperthyroidism - Answer: - excessive activity of the thyroid
gland
- caused by graves ds, thyroid ca, thyroid nodules
- CM: metabolic rate increases causing heat intolerance,
goiter, menstrual irregularularities, weight loss, diaphoresis,
fine tremor, tachycardia, frequent bowel movements,
restlessness, short attention span, hair loss, anorexia,
exophthalmos (bulging eyes), pretibial edema, hrt failure
Graves disease - Answer: - most common cause of
hyperthyroidism
- antibodies attach to thyroid cells & mimic fxn of TSH which
results in an increased secretion of T3 & T4 & overrides neg
feedback mech which regulate TSH secretion
- results in goiter dev
- CM: exophthalmos, periorbital edema, extraocular muscle
weakness l/t strabismus & diplopia
, thyroid nodules - Answer: - secrete extra thyroid hormones
- can dev d/t preg, puberty, autoimmune ds, viral infection,
genetics
- CM dev slowly and patients will not have exophthalmos or
pretibial myxedema
thyroid storm - Answer: - severe and may cause death
- triggered by an event such as infection, trauma,
cardiopulmonary disorders, burns, seizures, or surgery
- CM: extreme restlessness, agitation, delirium, seizures,
coma, severe tachycardia, heart failure, hyperthermia, vol
depletion, N/V/D
- caused by a sudden rel of hormones
Hypothyroidism - Answer: - insufficient amounts of thyroid
hormone
- CM: = confusion, syncope, slow speech, memory loss
depression
= cardiovascular: anemia, bradycardia, reduced SV, decreased