Test bank for Tietz Fundamentals of Clinical Chemistry a
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nd Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
m m m m m m
Chapters 1 - 49m m m m
,TietzmFundamentalsmofmClinicalmChemistrymandmMolecularmDiagnosticsm8thm EditionmTestmBank
Tablemofmcontents:
I.mPrinciplesmOfmLaboratorymMedicine
Chapterm1.mClinicalmChemistry,mMolecularmDiagnostics,mandmLaboratorymMedicine
Chapterm2.mSelectionmandmAnalyticalmEvaluationmofmMethodsm—
mWithmStatisticalmTechniques
Chapterm3.mClinicalmEvaluationmofmMethods
Chapterm4.mEvidence-BasedmLaboratorymMedicine
Chapterm5.mEstablishmentmandmUsemofmReferencemValues
Chapterm6.mSpecimenmCollection,mProcessing,mandmOthermPreanalyticalmVariables
Chapterm7.mQualitymManagement
II.mAnalyticalmTechniquesmAndmInstrumentation
Chapterm8.mPrinciplesmofmBasicmTechniquesmandmLaboratorymSafety
Chapterm9.mOpticalmTechniques
Chapterm10.mElectrochemistrymandmChemicalmSensors
Chapterm11.mElectrophoresis
Chapterm12.mChromatography
Chapterm13.mMassmSpectrometry
Chapterm14.mEnzymemandmRatemAnalyses
Chapterm15.mImmunochemicalmTechniques
Chapterm16mAutomation
Chapterm17.mPoint-of-CaremInstrumentation
III.m Analytes
Chapterm18.mAminomAcids,mPeptides,mandmProteins
Chapterm19.mSerummEnzymes
Chapterm20.mTumormMarkersmandmCancermGenes
Chapterm21.mKidneymFunctionmTestsm—mCreatinine,mGFR,mUrea,mandmUricmAcid
Chapterm22.mCarbohydrates
Chapterm23.mLipids,mLipoproteins,mApolipoproteins,mandmOthermCardiacmRiskmFactors
Chapterm24.mElectrolytesmandmBloodmGases
Chapterm25.mHormones
Chapterm26.m CatecholaminesmandmSerotonin
Chapterm27.m Vitamins,mTracemElements,mNutritionalmAssessment
Chapterm28.mHemoglobin,mIron,mandmBilirubin
Chapterm29.mPorphyrinsmandmPorphyrias
Chapterm30.mTherapeuticmDrugsmandmTheirmManagement
Chapterm31.mClinicalmToxicology
Chapterm32.m ToxicmMetals
IV.m Pathophysiology
Chapterm33.mDiabetes
,Chapterm34.m CardiovascularmDisease
Chapterm35.mKidneymDisease
Chapterm36.m PhysiologymandmDisordersmofmWater,mElectrolyte,mandmAcid-BasemMetabolism
Chapterm37.mmLivermDisease
Chapterm38.m GastrointestinalmandmPancreaticmDiseases
Chapterm39.mmDisordersmofmBonemandmMineralmMetabolism
Chapterm40.mmDisordersmofmthemPituitarymGland
Chapterm41.m DisordersmofmthemAdrenalmCortex
Chapterm42.m ThyroidmDisorders
Chapterm43.m Reproduction-RelatedmDisorders
Chapterm44.mmPregnancymandmPrenatalmTesting
Chapterm45.m NewbornmScreeningmandmInbornmErrorsmofmMetabolism
Chapterm46.mPharmacogenetics
V.m MolecularmDiagnostics
Chapterm47.mPrinciplesmofmMolecularmBiology
Chapterm48.mNucleicmAcidmTechniquesmandmApplications
Chapterm49.mGenomesmandmNucleicmAcidmAlterations
, Chapterm01:mClinicalmChemistry,mMolecularmDiagnostics,mandmLaboratorymMedicinemTes
tmBank
MULTIPLEmCHOICE
1. Anmindividualmworkingminmamclinicalmchemistrymlaboratorymismmarriedmtomamsalesmreprese
ntativemwhomworksmformamcompanymthatmsellsmchemistrymlaboratorymsupplies.mWhenmthe
mlaboratorymmanagermrequestsmamlistmofmneededmsupplies,mcostmofmsupplies,mandmvendor
s,mthismindividualmonlymrecommendsmthemspouse’smcompanymasmthemvendor.mThismismcons
ideredmtombema(n):
a. accountingmissue.
b. possiblemconflictmofminterest.
c. maintenancemofmconfidentialitymissue.
d. problemmwithmresourcemallocation.
ANS:m B
Concernmhasmbeenmraisedmovermtheminterrelationshipsmbetweenmpractitionersminmthemme
dicalmfieldmandmcommercialmsuppliersmofmdrugs,mdevices,mequipment,metc.,mtomthemmedica
lmprofession.
Similarly,mrelationshipsmhavembeenmscrutinizedmbetweenmclinicalmlaboratoriansmandmmanuf
acturersmandmprovidersmofmdiagnosticmequipmentmandmsupplies.mThesemconcernsmledmthem
NationalmInstitutesmofmHealthm(NIH)minm1995mtomrequiremofficialminstitutionalmreviewmofmfi
nancialmdisclosurembymresearchersmandmmanagementmofmsituationsminmwhichmdisclosuremin
dicatesmpotentialmconflictsmofminterest.
DIF: 1 REF:mmmPagem4-5 OBJ:m 6m|m7
2. Ampatientmvisitsmhermphysicianmstatingmthatmhermprescribedmpainkillermismnotmworkingmt
omreducemthempainmfollowingmhermrecentmsurgery.mAmfriendmofmthempatientmclaimsmthat
mthemsamempainkillerm“workedmwonders”mtomreducemhermpainmaftermthemsamemsurgery.m
Themphysicianmstatesmthatmthemdifferenceminmthemeffectmofmthemdrugmmightmbemcausedm
by
,mwhichmismstudiedminmpharmacogenetics.
a. epidemiology
b. anminheritedmdisease
c. amconflictmofminterest
d. amgeneticmvariationminmdrug-metabolizingmenzymes
ANS:m D
Pharmacogeneticsmismthemstudymofmthemgeneticmvariationmofmdrugmmetabolismm
betweenmindividuals.
DIF: 1 REF:mmmPagem3 OBJ:m 1
3. Johnmworksminmammolecularmdiagnosticsmlaboratorymandmreceivesmambloodmsamplemthat
mhasmthemnamemofmamclosemfriendmprintedmonmthembar-
codedmlabel.mThemgeneticmtestmthatmismorderedmonmthemfriend’smsamplemwouldmprovide
mdiagnosticminformationmaboutmamdisordermthatmhasmampoormprognosis,mandmthemtestmis
musuallymperformedmbymJohn.mHemasksmamfellowmemployeemtomanalyzemthemsamplemform
himmandmnotmdivulgemthemresults.mThismethicalmissuemconcerns:
a. confidentialitymofmpatientmgeneticmandmmedicalminformation.
b. amconflictmofminterest.
m m m m m m m m
nd Molecular Diagnostics,
m m m
8th Edition by Nader Rifai, PhD
m m m m m m
Chapters 1 - 49m m m m
,TietzmFundamentalsmofmClinicalmChemistrymandmMolecularmDiagnosticsm8thm EditionmTestmBank
Tablemofmcontents:
I.mPrinciplesmOfmLaboratorymMedicine
Chapterm1.mClinicalmChemistry,mMolecularmDiagnostics,mandmLaboratorymMedicine
Chapterm2.mSelectionmandmAnalyticalmEvaluationmofmMethodsm—
mWithmStatisticalmTechniques
Chapterm3.mClinicalmEvaluationmofmMethods
Chapterm4.mEvidence-BasedmLaboratorymMedicine
Chapterm5.mEstablishmentmandmUsemofmReferencemValues
Chapterm6.mSpecimenmCollection,mProcessing,mandmOthermPreanalyticalmVariables
Chapterm7.mQualitymManagement
II.mAnalyticalmTechniquesmAndmInstrumentation
Chapterm8.mPrinciplesmofmBasicmTechniquesmandmLaboratorymSafety
Chapterm9.mOpticalmTechniques
Chapterm10.mElectrochemistrymandmChemicalmSensors
Chapterm11.mElectrophoresis
Chapterm12.mChromatography
Chapterm13.mMassmSpectrometry
Chapterm14.mEnzymemandmRatemAnalyses
Chapterm15.mImmunochemicalmTechniques
Chapterm16mAutomation
Chapterm17.mPoint-of-CaremInstrumentation
III.m Analytes
Chapterm18.mAminomAcids,mPeptides,mandmProteins
Chapterm19.mSerummEnzymes
Chapterm20.mTumormMarkersmandmCancermGenes
Chapterm21.mKidneymFunctionmTestsm—mCreatinine,mGFR,mUrea,mandmUricmAcid
Chapterm22.mCarbohydrates
Chapterm23.mLipids,mLipoproteins,mApolipoproteins,mandmOthermCardiacmRiskmFactors
Chapterm24.mElectrolytesmandmBloodmGases
Chapterm25.mHormones
Chapterm26.m CatecholaminesmandmSerotonin
Chapterm27.m Vitamins,mTracemElements,mNutritionalmAssessment
Chapterm28.mHemoglobin,mIron,mandmBilirubin
Chapterm29.mPorphyrinsmandmPorphyrias
Chapterm30.mTherapeuticmDrugsmandmTheirmManagement
Chapterm31.mClinicalmToxicology
Chapterm32.m ToxicmMetals
IV.m Pathophysiology
Chapterm33.mDiabetes
,Chapterm34.m CardiovascularmDisease
Chapterm35.mKidneymDisease
Chapterm36.m PhysiologymandmDisordersmofmWater,mElectrolyte,mandmAcid-BasemMetabolism
Chapterm37.mmLivermDisease
Chapterm38.m GastrointestinalmandmPancreaticmDiseases
Chapterm39.mmDisordersmofmBonemandmMineralmMetabolism
Chapterm40.mmDisordersmofmthemPituitarymGland
Chapterm41.m DisordersmofmthemAdrenalmCortex
Chapterm42.m ThyroidmDisorders
Chapterm43.m Reproduction-RelatedmDisorders
Chapterm44.mmPregnancymandmPrenatalmTesting
Chapterm45.m NewbornmScreeningmandmInbornmErrorsmofmMetabolism
Chapterm46.mPharmacogenetics
V.m MolecularmDiagnostics
Chapterm47.mPrinciplesmofmMolecularmBiology
Chapterm48.mNucleicmAcidmTechniquesmandmApplications
Chapterm49.mGenomesmandmNucleicmAcidmAlterations
, Chapterm01:mClinicalmChemistry,mMolecularmDiagnostics,mandmLaboratorymMedicinemTes
tmBank
MULTIPLEmCHOICE
1. Anmindividualmworkingminmamclinicalmchemistrymlaboratorymismmarriedmtomamsalesmreprese
ntativemwhomworksmformamcompanymthatmsellsmchemistrymlaboratorymsupplies.mWhenmthe
mlaboratorymmanagermrequestsmamlistmofmneededmsupplies,mcostmofmsupplies,mandmvendor
s,mthismindividualmonlymrecommendsmthemspouse’smcompanymasmthemvendor.mThismismcons
ideredmtombema(n):
a. accountingmissue.
b. possiblemconflictmofminterest.
c. maintenancemofmconfidentialitymissue.
d. problemmwithmresourcemallocation.
ANS:m B
Concernmhasmbeenmraisedmovermtheminterrelationshipsmbetweenmpractitionersminmthemme
dicalmfieldmandmcommercialmsuppliersmofmdrugs,mdevices,mequipment,metc.,mtomthemmedica
lmprofession.
Similarly,mrelationshipsmhavembeenmscrutinizedmbetweenmclinicalmlaboratoriansmandmmanuf
acturersmandmprovidersmofmdiagnosticmequipmentmandmsupplies.mThesemconcernsmledmthem
NationalmInstitutesmofmHealthm(NIH)minm1995mtomrequiremofficialminstitutionalmreviewmofmfi
nancialmdisclosurembymresearchersmandmmanagementmofmsituationsminmwhichmdisclosuremin
dicatesmpotentialmconflictsmofminterest.
DIF: 1 REF:mmmPagem4-5 OBJ:m 6m|m7
2. Ampatientmvisitsmhermphysicianmstatingmthatmhermprescribedmpainkillermismnotmworkingmt
omreducemthempainmfollowingmhermrecentmsurgery.mAmfriendmofmthempatientmclaimsmthat
mthemsamempainkillerm“workedmwonders”mtomreducemhermpainmaftermthemsamemsurgery.m
Themphysicianmstatesmthatmthemdifferenceminmthemeffectmofmthemdrugmmightmbemcausedm
by
,mwhichmismstudiedminmpharmacogenetics.
a. epidemiology
b. anminheritedmdisease
c. amconflictmofminterest
d. amgeneticmvariationminmdrug-metabolizingmenzymes
ANS:m D
Pharmacogeneticsmismthemstudymofmthemgeneticmvariationmofmdrugmmetabolismm
betweenmindividuals.
DIF: 1 REF:mmmPagem3 OBJ:m 1
3. Johnmworksminmammolecularmdiagnosticsmlaboratorymandmreceivesmambloodmsamplemthat
mhasmthemnamemofmamclosemfriendmprintedmonmthembar-
codedmlabel.mThemgeneticmtestmthatmismorderedmonmthemfriend’smsamplemwouldmprovide
mdiagnosticminformationmaboutmamdisordermthatmhasmampoormprognosis,mandmthemtestmis
musuallymperformedmbymJohn.mHemasksmamfellowmemployeemtomanalyzemthemsamplemform
himmandmnotmdivulgemthemresults.mThismethicalmissuemconcerns:
a. confidentialitymofmpatientmgeneticmandmmedicalminformation.
b. amconflictmofminterest.
