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Pharm HESI Practice Exam Latest Update 2026 | Questions and Answers for Nursing Students

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Stay up-to-date with the latest 2026 update of the Pharmacology HESI Practice Exam. This comprehensive guide includes verified questions and answers covering drug classifications, mechanisms of action, side effects, therapeutic uses, and patient safety. Designed for nursing students preparing for HESI exams, it reinforces critical pharmacology concepts, enhances clinical judgment, and provides real exam-style questions to boost confidence and ensure success on test day.

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Pharm HESI Practice Exam Latest update(QUESTIONS AND ANSWERS)Page 1 1 of 18

D. Rise slowly when getting out of bed or chair.


The nurse is caring for a client who has
taken atenolol for 2 years. The healthcare
provider recently changed the medication to
enalapril to manage the client's blood
pressure. Which instruction should the nurse
provide the client regarding the new
medication?

A. Take the medication at bedtime.
B. Report presence of increased bruising.
C. Check pulse before taking medication.
D. Rise slowly when getting out of bed or
chair.




C. Consult with healthcare provider about another treatment for this effect.


A female client calls the clinic and talks with
the nurse to inquire about a possible
reaction after taking amoxicillin for 5 days.
She reports having vaginal discomfort,
itching, and a white discharge. The nurse
should discuss which action with the client?

A. Discontinue the antibiotic because
original symptoms have subsided.
B. Continue taking medication until finished
until the symptoms subside.
C. Consult with healthcare provider about
another treatment for this effect.
D. Use an over-the-counter (OTC) vaginal
wash to flush out the secretions.




C, D


The nurse is making early morning rounds
on a group of clients when a client begins
exhibiting symptoms of an acute asthma
attack. The nurse administers a PRN
prescription for a Beta 2 receptor agonist
agent. Which client response should the
nurse expect?

A. Tachycardia.
B. Increased blood pressure.
C. Rapid resolution of wheezing.
D. Improved pulse oximetry values.
E. Reduce fever airway inflammation.




B. Give the medication as prescribed and continue to monitor the client.


A client prescribed atenolol has a blood
pressure of 120/68 mmHg, displaying a
sinus bradycardia with a rate of 58
beats/minute, and a P-R interval of 0.24.
Which action should the nurse take?

A. Lower the head of the bed and assess the
client for orthostatic vital sign changes.
B. Give the medication as prescribed and
continue to monitor the client.
C. Prepare to administer atropine sulfate IV
push.
D. Hold the prescribed dose and contact the
healthcare provider.




4/8/2026, 5:45:43 AM 1Pharm HESI Practice Exam Latest update(QUESTIONS AND ANSWERS).pdf

,Pharm HESI Practice Exam Latest update(QUESTIONS AND ANSWERS)Page 2 2 of 18

A. Withhold the scheduled dose.


The nurse is preparing the 0900 dose of
losartan (Cozaar), an angiotensin II receptor
blocker (ARB), for a client with hypertension
and heart failure. The nurse reviews the
client's laboratory results and notes that the
client's serum potassium level is 5.9 mEq/L.
Which action should the nurse take first?

A. Withhold the scheduled dose.
B. Check the client's apical pulse.
C. Notify the healthcare provider.
D. Repeat the serum potassium level.




1. Albuterol (Proventil) puffs.
Upon admission to the emergency center, an 2. Salmeterol (Serevent Diskus).
adult client with acute status asthmaticus is 3. Prednisone (Deltasone) orally.
prescribed this series of medications. In 4. Gentamicin (Garamycin) IM.
which order should the nurse administer the
prescribed medications? (Arrange from first
to last.)


A. Apply the patch at least 4 hours prior to departure.


An adult client is given a prescription for a
scopolamine patch (Transderm Scop) to
prevent motion sickness while on a cruise.
Which information should the nurse provide
to the client?

A. Apply the patch at least 4 hours prior to
departure.
B. Change the patch every other day while
on the cruise.
C. Place the patch on a hairless area at the
base of the skull.
D. Drink no more than 2 alcoholic drinks
during the cruise.




D. Take the medication with food.

A client with giardiasis is taking
metronidazole (Flagyl) 2 grams PO. Which
information should the nurse include in the
client's instruction?

A. Notify the clinic of any changes in the
color of urine.
B. Avoid overexposure to the sun.
C. Stop the medication after the diarrhea
resolves.
D. Take the medication with food.




4/8/2026, 5:45:43 AM 2Pharm HESI Practice Exam Latest update(QUESTIONS AND ANSWERS).pdf

, Pharm HESI Practice Exam Latest update(QUESTIONS AND ANSWERS)Page 3 3 of 18

A. Use contraception during intercourse.


A female client with rheumatoid arthritis
takes ibuprofen (Motrin) 600 mg PO 4 times
a day. To prevent gastrointestinal bleeding,
misoprostol (Cytotec) 100 mcg PO is
prescribed. Which information is most
important for the nurse to include in client
teaching?

A. Use contraception during intercourse.
B. Ensure the Cytotec is taken on an empty
stomach.
C. Encourage oral fluid intake to prevent
constipation.
D. Take Cytotec 30 minutes prior to Motrin.




B. Notify the healthcare provider.

A client with osteoarthritis receives a new
prescription for celecoxib (Celebrex) orally
for symptom management. The nurse notes
the client is allergic to sulfa. Which action is
most important for the nurse to implement
prior to administering the first dose?

A. Review the client's hemoglobin results.
B. Notify the healthcare provider.
C. Inquire about the reaction to sulfa.
D. Record the client's vital signs.




A. Potassium level of 3.1 mEq/L.

A client is admitted to the hospital for a new
onset of supraventricular tachycardia (SVT)
and is prescribed digoxin. For which
laboratory finding should the nurse notify the
healthcare provider immediately?

A. Potassium level of 3.1 mEq/L.
B. Sodium level of 132 mEq/L.
C. Calcium level of 8.6 mg/dL.
D. Magnesium level of 1.2 mEq/L.




4/8/2026, 5:45:43 AM 3Pharm HESI Practice Exam Latest update(QUESTIONS AND ANSWERS).pdf

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