MSN 671 NEI Global Video Questions
Communication between human CNS neurons at synapses is: - answer Chemical
An example of volume neurotransmission is: - answer Dopamine in the prefrontal cortex
The direct role of transcription factors is to: - answer Influence gene expression
The term epigenetics refers to: - answerA process determining whether a given gene is
expressed or silenced
Presynaptic reuptake transporters are a major method of inactivation for which of the
following? - answerSerotonin and GABA
What is constitutive activity? - answerSignal transduction when no agonist or inverse
agonist is bound to the receptor.
A partial agonist has what effect on neurotransmission? - answerNet agonism when
neurotransmission is deficient.
Net antagonism when neurotransmission is excessive.
Both of the above answers are correct
Agonists cause ligand-gated ion channels to: - answerOpen more frequently
Which of the following is true? - answerBoth positive and negative allosteric
modulations are possible only in the presence of a neurotransmitter
When voltage-sensitive sodium channels are open and activated, the flow of sodium is:
- answerInto the neuron
Which of the following are involved in regulating neurotransmission via excitation-
secretion coupling? - answerBoth of these which are voltage-sensitive sodium channels
and voltage-sensitive calcium channels.
A 21-year-old man who has just been diagnosed with schizophrenia presents with his
parents. He speaks with a reserved and simple language processing style; he is able to
understand and relate to simple questions but seems to get lost when the pace of the
conversation between the clinician and parents accelerates. when reviewing the
patient's history, what pattern of cognitive functioning prior to psychosis onset would you
be most likely to find? - answerImpaired cognitive functioning premorbidly with further
decline during the prodromal phase.
, Dopamine (DA) receptors can be categorized as D1 like (D1 and D5 receptors) and D2
like (D2, D3, and D4 receptors). What differentiates the two groups of receptors? -
answerD1-like receptors are excitatory and D2-like receptors are inhibitory.
Symptoms of schizophrenia are hypothetically attributable to malfucntioning in the: -
answerMesocortical and mesolimbic pathways
For which set of disorders is psychosis considered an associated feature rather than a
defining feature for diagnosis? - answerBipolar mania, Parkinson's disease.
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of: -
answerGlutamate and glycine.
A leading hypothesis of psychosis is: - answerHypofunctioning NMDA receptors.
Dysfunction of NMDA-receptor containing synapses is hypothesized to lead to
excessive glutamate release in the ventral tegmental area. Downstream, this is
hypothesized to lead to what effects on dopamine (DA)? - answerExcessive DA release
in the NA and reduced DA release in the PFC.
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea
that aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which: - answerRarely used synapses are pruned, while
frequently used synapses are preserved.
What three neurotransmitter systems are implicated in the neuropathology of
psychosis? - answerSerotonin, glutamate, dopamine
What receptor subtypes act as presynaptic autoreceptors to inhibit serotonin release? -
answer5HT1A and 5HT1B/D receptors
Stimulation of 5HT3 receptors on GABA interneurons leads to inhibited release of: -
answerAcetylcholine, norepinephrine, and serotonin.
Psychosis in Parkinson's disease or dementia may occur due to upregulation of which
postsynaptic serotonin receptor on glutamate neurons in the prefrontal cortex? -
answer5HT2A
Antagonism of dopamine 2 receptors in the mesolimbic/mesostriatal pathway may lead
to: - answerImprovement in positive symptoms of psychosis and development of
secondary negative symptoms.
A 44-year-old male with schizophrenia has been treated with a dopamine 2 receptor
antagonist since initial diagnosis twelve years ago. He has recently begun experiencing,
difficulty with fluid movement of his arms as well as involuntary facial grimaces. Which
Communication between human CNS neurons at synapses is: - answer Chemical
An example of volume neurotransmission is: - answer Dopamine in the prefrontal cortex
The direct role of transcription factors is to: - answer Influence gene expression
The term epigenetics refers to: - answerA process determining whether a given gene is
expressed or silenced
Presynaptic reuptake transporters are a major method of inactivation for which of the
following? - answerSerotonin and GABA
What is constitutive activity? - answerSignal transduction when no agonist or inverse
agonist is bound to the receptor.
A partial agonist has what effect on neurotransmission? - answerNet agonism when
neurotransmission is deficient.
Net antagonism when neurotransmission is excessive.
Both of the above answers are correct
Agonists cause ligand-gated ion channels to: - answerOpen more frequently
Which of the following is true? - answerBoth positive and negative allosteric
modulations are possible only in the presence of a neurotransmitter
When voltage-sensitive sodium channels are open and activated, the flow of sodium is:
- answerInto the neuron
Which of the following are involved in regulating neurotransmission via excitation-
secretion coupling? - answerBoth of these which are voltage-sensitive sodium channels
and voltage-sensitive calcium channels.
A 21-year-old man who has just been diagnosed with schizophrenia presents with his
parents. He speaks with a reserved and simple language processing style; he is able to
understand and relate to simple questions but seems to get lost when the pace of the
conversation between the clinician and parents accelerates. when reviewing the
patient's history, what pattern of cognitive functioning prior to psychosis onset would you
be most likely to find? - answerImpaired cognitive functioning premorbidly with further
decline during the prodromal phase.
, Dopamine (DA) receptors can be categorized as D1 like (D1 and D5 receptors) and D2
like (D2, D3, and D4 receptors). What differentiates the two groups of receptors? -
answerD1-like receptors are excitatory and D2-like receptors are inhibitory.
Symptoms of schizophrenia are hypothetically attributable to malfucntioning in the: -
answerMesocortical and mesolimbic pathways
For which set of disorders is psychosis considered an associated feature rather than a
defining feature for diagnosis? - answerBipolar mania, Parkinson's disease.
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of: -
answerGlutamate and glycine.
A leading hypothesis of psychosis is: - answerHypofunctioning NMDA receptors.
Dysfunction of NMDA-receptor containing synapses is hypothesized to lead to
excessive glutamate release in the ventral tegmental area. Downstream, this is
hypothesized to lead to what effects on dopamine (DA)? - answerExcessive DA release
in the NA and reduced DA release in the PFC.
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea
that aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which: - answerRarely used synapses are pruned, while
frequently used synapses are preserved.
What three neurotransmitter systems are implicated in the neuropathology of
psychosis? - answerSerotonin, glutamate, dopamine
What receptor subtypes act as presynaptic autoreceptors to inhibit serotonin release? -
answer5HT1A and 5HT1B/D receptors
Stimulation of 5HT3 receptors on GABA interneurons leads to inhibited release of: -
answerAcetylcholine, norepinephrine, and serotonin.
Psychosis in Parkinson's disease or dementia may occur due to upregulation of which
postsynaptic serotonin receptor on glutamate neurons in the prefrontal cortex? -
answer5HT2A
Antagonism of dopamine 2 receptors in the mesolimbic/mesostriatal pathway may lead
to: - answerImprovement in positive symptoms of psychosis and development of
secondary negative symptoms.
A 44-year-old male with schizophrenia has been treated with a dopamine 2 receptor
antagonist since initial diagnosis twelve years ago. He has recently begun experiencing,
difficulty with fluid movement of his arms as well as involuntary facial grimaces. Which
