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a monoclonal antibody against GD2 that was the first immunotherapy agent
approved by the FDA specifically for pediatric cancer
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1 interleukin 2 2 obiltoxaximab
3 elotuzumab 4 dinutuximab
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apoptosis natural cell death
, necrosis cell death that results from an insult, such as a lack
of blood supply, physical trauma, or cytotoxic
therapy that leads to rupture of the cell membrane
and spilling of cell contents
malignant cells cells that do not have a finite number of cell
divisions as normal cells do; lost the ability to
undergo apoptosis; can keep replicating and
dividing indefinitely
aberrant cell division the primary characteristic of malignant cells
tumor suppression genes these keep normal cellular growth in check by
regulating cell division, DNA repair, and apoptosis;
if damaged or absent, cells lack the appropriate
growth-inhibiting signals and grow out of control
nadir the period of time after a course of chemotherapy
in which the patients blood counts are lowest
physical barrier the first layer of defense that provides protective
immunity through anatomic barriers; ex. skin,
mucous membranes
innate passive immunity the second layer of defense that provides rapid,
nonspecific response to invading pathogens
adaptive acquired immunity the third layer of defense
tumor marker a characteristic feature or byproduct of a tumor
cell that serves as a useful indication of tumor cell
origin or tumor activity