Inflammatory Bowel Disease (IBD)
Quiz
The pharmacist in the clinic reviews AF's medication list. Which, if any, of the
medications shown would require the dose of Entocort EC to be reduced? – answer
Diflucan
* Budesonide is a major CYP 3A4 substrate
* Potent 3A4 inhibitors (like fluconazole) used concomitantly may necessitate a
budesonide dose reduction
Which of the following monoclonal antibodies are approved for the treatment of AF's
disease? SATA - answer Infliximab
Adalimumab
Natalizumab
Certolizumab
* Etanercept (Enbrel) is not approved for any type of IBD
* MAbs approved for IBD have specific FDA-approved indications for UC, CD, or both
Which medication can be used once weekly to treat Crohn's disease? -
answerMethotrexate - can be given once weekly by IM or SC injection to treat Crohn's
disease
* Cyclosporine and tofacitinib are only indicated for severe UC
* Tysabri is dosed every 4 weeks
What is meant by the term "distal" ulcerative colitis? - answerNear the rectum
* Can include the most distal part of the colon, called the sigmoid colon, or the most
distal portion of the descending colon
Which of the following is an interleukin receptor antagonist approved for the treatment of
Crohn's disease and ulcerative colitis? - answerUstekinumab (Stelara)
* Stelara is a MAb that blocks interleukin receptors
* Approved for Crohn's disease, ulcerative colitis and psoriasis
Which of the following are true statements regarding mesalamine enemas? -
answerPatients should ideally retain drug in the rectum overnight (8 hours)
* Mesalamine enemas should be administered once daily at bedtime and, ideally
retained for 8 hours
* Bowels should be emptied immediately before use
* Topical products not effective for proximal disease
* Each bottle is single-use
Quiz
The pharmacist in the clinic reviews AF's medication list. Which, if any, of the
medications shown would require the dose of Entocort EC to be reduced? – answer
Diflucan
* Budesonide is a major CYP 3A4 substrate
* Potent 3A4 inhibitors (like fluconazole) used concomitantly may necessitate a
budesonide dose reduction
Which of the following monoclonal antibodies are approved for the treatment of AF's
disease? SATA - answer Infliximab
Adalimumab
Natalizumab
Certolizumab
* Etanercept (Enbrel) is not approved for any type of IBD
* MAbs approved for IBD have specific FDA-approved indications for UC, CD, or both
Which medication can be used once weekly to treat Crohn's disease? -
answerMethotrexate - can be given once weekly by IM or SC injection to treat Crohn's
disease
* Cyclosporine and tofacitinib are only indicated for severe UC
* Tysabri is dosed every 4 weeks
What is meant by the term "distal" ulcerative colitis? - answerNear the rectum
* Can include the most distal part of the colon, called the sigmoid colon, or the most
distal portion of the descending colon
Which of the following is an interleukin receptor antagonist approved for the treatment of
Crohn's disease and ulcerative colitis? - answerUstekinumab (Stelara)
* Stelara is a MAb that blocks interleukin receptors
* Approved for Crohn's disease, ulcerative colitis and psoriasis
Which of the following are true statements regarding mesalamine enemas? -
answerPatients should ideally retain drug in the rectum overnight (8 hours)
* Mesalamine enemas should be administered once daily at bedtime and, ideally
retained for 8 hours
* Bowels should be emptied immediately before use
* Topical products not effective for proximal disease
* Each bottle is single-use
