MRCP HAEMATOLOGY EXAM
QUESTIONS AND ANSWERS 2026
VERIFIED.
What is pernicious anaemia - ANS Autoimmune attack against gastric parietal cells (that
secrete intrinsic factor & acid)
What is vitamin B12 bound to - ANS Intrinsic factor - secreted by the gastric parietal cells
The following complications are seen in what?
Peripheral neuropathy
Subacute combined degeneration of the cord
Dementia
Optic atrophy - ANS Vitamin B12 deficiency - needed for nervous tissue
What antibodies are specific for parietal anaemia - ANS Intrinsic factor antibodies
Describe adult haemoglobin - ANS HbA2 - contains 2 alpha & 2 beta chains
What are teardrop cells seen in - ANS Myelofibrosis
@2026/2027 ALLRIGHTS RESERVED.
, What are fragmented cells & helmet cells seen in - ANS Microangiopathic haemolysis
why might you see Spherocytes - ANS Any cause of haemolysis - particularly warm
autoimmune haemolysis & hereditary spherocytosis
you will see what in a blood film in the following condition?
Liver disease
post-splenectomy
iron deficiency
thalassaemias
haemoglobinopathies - ANS Target cells
what virus causes an aplastic crisis - ANS Parvovirus B19
indications for transfusion in SCD - ANS frequent severe sickle pain crisis
central nervous system sickling
priapism
chest syndrome not responding
preop
in pregnancy
what causes alpha-thalassaemia - ANS lack of alpha chains to produce haemoglobin
how does alpha-thalassaemia present if only 1 alpha gene is affected? - ANS Mild
microcytosis, no anaemia
@2026/2027 ALLRIGHTS RESERVED.
QUESTIONS AND ANSWERS 2026
VERIFIED.
What is pernicious anaemia - ANS Autoimmune attack against gastric parietal cells (that
secrete intrinsic factor & acid)
What is vitamin B12 bound to - ANS Intrinsic factor - secreted by the gastric parietal cells
The following complications are seen in what?
Peripheral neuropathy
Subacute combined degeneration of the cord
Dementia
Optic atrophy - ANS Vitamin B12 deficiency - needed for nervous tissue
What antibodies are specific for parietal anaemia - ANS Intrinsic factor antibodies
Describe adult haemoglobin - ANS HbA2 - contains 2 alpha & 2 beta chains
What are teardrop cells seen in - ANS Myelofibrosis
@2026/2027 ALLRIGHTS RESERVED.
, What are fragmented cells & helmet cells seen in - ANS Microangiopathic haemolysis
why might you see Spherocytes - ANS Any cause of haemolysis - particularly warm
autoimmune haemolysis & hereditary spherocytosis
you will see what in a blood film in the following condition?
Liver disease
post-splenectomy
iron deficiency
thalassaemias
haemoglobinopathies - ANS Target cells
what virus causes an aplastic crisis - ANS Parvovirus B19
indications for transfusion in SCD - ANS frequent severe sickle pain crisis
central nervous system sickling
priapism
chest syndrome not responding
preop
in pregnancy
what causes alpha-thalassaemia - ANS lack of alpha chains to produce haemoglobin
how does alpha-thalassaemia present if only 1 alpha gene is affected? - ANS Mild
microcytosis, no anaemia
@2026/2027 ALLRIGHTS RESERVED.
