Pathophysiology of the Endocrine System | High-Yield Medical/Nursing Revision Pack

Endocrine System After this unit, the learner will be able to describe the pathophysiology of: Pituitary Gland disorders Thyroid Gland disorders Parathyroid Gland disorders Adrenal Gland disorders Pancreatic Gland disorders Receptor associated disorders a) Decrease in the number of receptors →↓hormone - receptor bindingb) Impaired receptor function → ↓sensitivity to the hormone c) Antibodies against specific receptors d) Unusual expression of receptor function Intracellular disorders- disorders present inside the target cell a) inadequate synthesis of the second messengers b) number of intracellular receptors may be decreased or they may have altered affinity for hormones c) alterations in generation of new messenger RNA or absence of substrates for new protein synthesis