Concurrent drug use with amphetamines
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Other drugs may be sought concurrently with amphetamines in an attempt
to antagonize various toxic effects of the amphetamines
- Alternatively, an individual who is experiencing drowsiness due to opioids
may seek out a CNS stimulant like amphetamines to be more alert and
responsive during the day or while performing tasks
- These can lead to additional issues like drug-drug interactions, misusing
of additional drugs, and SUDs
Characteristics of Addictive Drugs: Reduce Anxiety
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, Some drugs are addictive because they reduce anxiety in the person taking
the drug
- These drugs include CNS depressants such as:
Benzodiazepines, barbiturates
Cross Tolerance
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Can occur between pharmacologically similar drugs
- Defined as the resistance or tolerance to one drug
because of the resistance or tolerance to a
pharmacologically similar drug
ADME of caffeine: metabolism
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Genetics determine the rate at which we metabolize and excrete caffeine
- There are rapid metabolizers and slow metabolizers
- This may explain who drinking coffee with dinner keeps some individuals
awake, but not others
The Opioid Crisis
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, Current opioid crisis has brought to light the impact and prevalence of
substance use disorders (SUD) in Canadian society
- From January 2016 to September 2020, 19355 Canadians died of apparent
opioid overdose
- Means that roughly every 2 hours, a Canadian life was lost to opioid use
- 94% of these were deemed accidental
Clearly the opioid crisis has had devastating impacts on individuals,
families, communities and populations
- Establishment of community intervention programs, research into new
therapies, and development of educational materials have all been
implemented to raise awareness and provide support to individuals and
their networks
- Huge economic impact from lost productivity as 70% of opioid overdose-
related deaths occur in those younger than 50 years old
- Many careers have been cut short from this disease
Effects of anabolic steroids
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Appear to have greater effects in individuals with lower basal circulating
levels of testosterone
- The effects also differ depending on whether a low to moderate, or large
dose is administered
Low to moderate doses: have modest effects on the average adult
Large doses: in an athlete at the peak of training, large doses in
combination with a diet high in protein yields significant increases in lean
body mass, body weight and strength
- aggressive behaviour induced by anabolic steroids contributes to their
performance enhancement efforts
Harm Reduction
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An approach that seeks to reduce/prevent the negative consequences of
substance use and improve health without judgment, coercion, or
discrimination, and without necessarily requiring the person to stop use the
substance
Classes of Drugs Used in Sports: Amphetamines
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Amphetamines are powerful psychomotor stimulants producing increased
alertness, a feeling of power, reduced fatigue, increased aggression, and
increased responsiveness
- It also increases heart rate and blood pressure
- All of these effects contribute to increased endurance and speed
- Amphetamines also cause appetite suppression, which can be helpful in
sports that benefit from weight loss
Mechanism of action of nicotine
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Other drugs may be sought concurrently with amphetamines in an attempt
to antagonize various toxic effects of the amphetamines
- Alternatively, an individual who is experiencing drowsiness due to opioids
may seek out a CNS stimulant like amphetamines to be more alert and
responsive during the day or while performing tasks
- These can lead to additional issues like drug-drug interactions, misusing
of additional drugs, and SUDs
Characteristics of Addictive Drugs: Reduce Anxiety
Give this one a try later!
, Some drugs are addictive because they reduce anxiety in the person taking
the drug
- These drugs include CNS depressants such as:
Benzodiazepines, barbiturates
Cross Tolerance
Give this one a try later!
Can occur between pharmacologically similar drugs
- Defined as the resistance or tolerance to one drug
because of the resistance or tolerance to a
pharmacologically similar drug
ADME of caffeine: metabolism
Give this one a try later!
Genetics determine the rate at which we metabolize and excrete caffeine
- There are rapid metabolizers and slow metabolizers
- This may explain who drinking coffee with dinner keeps some individuals
awake, but not others
The Opioid Crisis
Give this one a try later!
, Current opioid crisis has brought to light the impact and prevalence of
substance use disorders (SUD) in Canadian society
- From January 2016 to September 2020, 19355 Canadians died of apparent
opioid overdose
- Means that roughly every 2 hours, a Canadian life was lost to opioid use
- 94% of these were deemed accidental
Clearly the opioid crisis has had devastating impacts on individuals,
families, communities and populations
- Establishment of community intervention programs, research into new
therapies, and development of educational materials have all been
implemented to raise awareness and provide support to individuals and
their networks
- Huge economic impact from lost productivity as 70% of opioid overdose-
related deaths occur in those younger than 50 years old
- Many careers have been cut short from this disease
Effects of anabolic steroids
Give this one a try later!
Appear to have greater effects in individuals with lower basal circulating
levels of testosterone
- The effects also differ depending on whether a low to moderate, or large
dose is administered
Low to moderate doses: have modest effects on the average adult
Large doses: in an athlete at the peak of training, large doses in
combination with a diet high in protein yields significant increases in lean
body mass, body weight and strength
- aggressive behaviour induced by anabolic steroids contributes to their
performance enhancement efforts
Harm Reduction
, Give this one a try later!
An approach that seeks to reduce/prevent the negative consequences of
substance use and improve health without judgment, coercion, or
discrimination, and without necessarily requiring the person to stop use the
substance
Classes of Drugs Used in Sports: Amphetamines
Give this one a try later!
Amphetamines are powerful psychomotor stimulants producing increased
alertness, a feeling of power, reduced fatigue, increased aggression, and
increased responsiveness
- It also increases heart rate and blood pressure
- All of these effects contribute to increased endurance and speed
- Amphetamines also cause appetite suppression, which can be helpful in
sports that benefit from weight loss
Mechanism of action of nicotine
Give this one a try later!