Questions and verified Answers
Pharmacologic Agents - CORRECT ANSWERS
Therapeutic Strategies - CORRECT ANSWERS
Risks and Limitations of - CORRECT ANSWERS
AC pts in US - CORRECT ANSWERS 6 million patients
Reversing therapy is a RISK vs RISK decision - CORRECT ANSWERS Involves fully informed
decision making from the interdisciplinary team.
Reversal Decision Pathway (ADR) - CORRECT ANSWERS Assess Bleeding; Determine
Anticoagulation Therapy; Rapid Labratory Testing
Major Bleeding : Unstable pt - CORRECT ANSWERS Hemodynamically unstable (SBP< 90 or
decrease of 40mmHg. MAP<65 or low organ perfusion (decrease in urine output)
Major Bleeding: In an anatomically critical location - CORRECT ANSWERS CVA
Major bleeding determined by Hgb drop - CORRECT ANSWERS If drops by >/= 2g/dL is a
large drop in Hgb
Major bleeding : transfusion - CORRECT ANSWERS If requires > or = 2 units of RBCs
, Non-major bleeding - CORRECT ANSWERS All bleeding classified as major (may still required
intervention or hospitalization)
Assessing bleeding symptoms: - CORRECT ANSWERS Intracranial (HA, emesis or other Neuro
signs), other CNS hemorrage (monoccular eye pain, vision changes, blindness, back pain, blilateral
weekness), pericardial tamponade (SOB, tachypnea, tachycardia, hyptension jugular venous distention),
airway (including posteria epitaxis) (hemoptysis, SOB, hypoxia), Hemothorax/intraabdominal bleeding
(tachypnea, tachycardia, hypotension, back/flank/hip pain), and extremity bleeds (pain, swelling,
weakness, decreased range of motion)
Determining anticoagulation therapy - CORRECT ANSWERS Med Recon (what med, dose,
timing since last administered, monitoring parameters, use of additional anticoagulants/antiplatelet
agents)
Timing since last administered - CORRECT ANSWERS Based on 5 half-life washout Normal
RENAL fxn.
Dabigatrin (t-1/2= 12-17 hours. Washout: 2.5 to 3.5 days post last dose)
Rivaroxaban (t-1/2 5-9 hours. Washout 1-2 days after last dose)
Apixaban t-/12 8-15 hours. Washout 1.5 to 3 days after last dose
Edoxaban t1/2 6-11 hours. Washout 1.3 to 2 days after last dose
Rapid Testing availble - CORRECT ANSWERS PTT (prothrombin time), antiXa, for DOACs, INR
for warfarin, aPTT for heparin.
dTT (dilute thrombin time, ECT Ecarin clotting time or ECA Ecarin assay can be useful for dabigatran
reversal
Not 100% essential -- can help in tailoring therapy if availble.
Other testing needed - CORRECT ANSWERS Hgb, HCT (severity of bleed, need for blood),
platelets (need for supplementation, overall levels). Renal function (clearance of agent on board) LIver
tests
DIC tests ( d dimer or fibrinogen testing)