KREB’S CYCLE
(TRICARBOXYLIC ACID (TCA) CYCLE, CITRIC
ACID CYCLE)
,Overall goal
□Makes ATP/GTP
□Makes NADH
□Makes FADH
2
□Requires carbohydrates
(CHO) to run
, Geography
•Glycolysis in the cytosol
•Krebs in mitochondrial matrix
•Mitochondrion
•Outer membrane very permeable
• Space between membranes called intermembrane space
•Inner membrane (cristae)
• Permeable to pyruvate,
• Impermeable to fatty acids, NAD, etc
•Matrix is inside inner membrane
(TRICARBOXYLIC ACID (TCA) CYCLE, CITRIC
ACID CYCLE)
,Overall goal
□Makes ATP/GTP
□Makes NADH
□Makes FADH
2
□Requires carbohydrates
(CHO) to run
, Geography
•Glycolysis in the cytosol
•Krebs in mitochondrial matrix
•Mitochondrion
•Outer membrane very permeable
• Space between membranes called intermembrane space
•Inner membrane (cristae)
• Permeable to pyruvate,
• Impermeable to fatty acids, NAD, etc
•Matrix is inside inner membrane
