2
MH 701 Newest exam 1 with precise detailed answers
|| || || || || || || ||
What is the DSM5 - ✔✔Diagnostic and Statistical Manual of Mental Disorders
|| || || || || || || || || || ||
Definitions of disorders based on clinical features.
|| || || || || ||
Diagnostic criteria is a list of clinical features That need to be present for diagnosis.
|| || || || || || || || || || || || || || ||
Increases reliability for diagnostic process.
|| || || ||
Pharmacokinetics - ✔✔What the body does to a drug.(metabolism) Goal is to make is more || || || || || || || || || || || || || || ||
water soluble so it can be excreted.
|| || || || || ||
Pharmacodynamics - ✔✔The study of what the drug does to the body. Interaction between || || || || || || || || || || || || || ||
the drug and the receptor.
|| || || ||
Pharmacogenetics - ✔✔Differences in how individuals metabolize drugs. (Ultra rapid || || || || || || || || || ||
metabolizers or extensive metabolizers of slow metabolizers) || || || || || ||
Toxicity - ✔✔the degree to which a substance is biologically harmful. When a person has
|| || || || || || || || || || || || || || ||
accumulated too much in the blood stream. || || || || || ||
Steady state - ✔✔The time which the concentration of the drug in the body stays consistent.
|| || || || || || || || || || || || || || ||
(usually 4-5 half lives if the drug is given consistently)
|| || || || || || || || || ||
Half-Life - ✔✔Safe dosage interval. The amount of time it takes a drug to be reduced in the
|| || || || || || || || || || || || || || || || || ||
blood by 50%.
|| ||
What are the general classes of psychotropic medications? - ✔✔Antidepressants,
|| || || || || || || || || ||
antipsychotics, mood stabilizers, hypnotics, anxiolytics, cognitive enhancer and stimulants.
|| || || || || || || ||
,2
What is meant by a drug causing an agonist type of reaction at the receptor site? - ✔✔A
|| || || || || || || || || || || || || || || || || ||
drug or medication that binds to a specific receptor producing an effect identical to that
|| || || || || || || || || || || || || || ||
usually produced by the neurotransmitter affecting that receptor. (Drugs are often designed
|| || || || || || || || || || || ||
as receptor agonists to treat a variety of diseases in which the original neurotransmitter is
|| || || || || || || || || || || || || || ||
missing or diminished.) || ||
What is meant by a drug causing an antagonist type of reaction at the receptor site? - ✔✔A
|| || || || || || || || || || || || || || || || || ||
compound that binds to a receptor that blocks or reduces the action of another substance at
|| || || || || || || || || || || || || || || ||
the receptor site involved.
|| || ||
Competitive antagonists: - ✔✔Compete with an agonist for a receptor. EX, drugs for || || || || || || || || || || || || ||
schizophrenia block dopamine 2 receptors, naltrexone and naloxone are opioid antagonists. || || || || || || || || || ||
What is meant by a drug causing a partial agonist type of action at a receptor site? - ✔✔A
|| || || || || || || || || || || || || || || || || || ||
compound that possess affinity for a receptor, but elicits a partial pharmacological response
|| || || || || || || || || || || || ||
at the receptor involved. Partial agonists are often structural analogs of agonist molecules. If
|| || || || || || || || || || || || ||
neurotransmitters a low, partial agonists may behave as agonists.
|| || || || || || || || ||
What is meant by a drug causing an inverse agonist type of action at the receptor site? -
|| || || || || || || || || || || || || || || || || ||
✔✔An inverse agonist is an agent that binds to the same receptors as an agonist for that
|| || || || || || || || || || || || || || || || ||
receptor but produces the opposite pharmacological effect. || || || || || ||
What is the significance of understanding about CYP 450 when prescribing various
|| || || || || || || || || || || ||
medications that may affect this? - ✔✔CYP 450 is an enzyme that helps break down drugs.
|| || || || || || || || || || || || || || || ||
There are some drugs that are either inhibitors or inducers of the CYP 450 enzyme.
|| || || || || || || || || || || || || || ||
The inhibitors inhibit the enzyme from working, therefore decreasing drug metabolism and
|| || || || || || || || || || || ||
can cause toxicity.
|| ||
The inducers speed up the CYP 450 enzyme , therefore increases the drug metabolism and
|| || || || || || || || || || || || || || ||
causes a sub-therapeutic affect. || || ||
,2
What medications are most affected to the CYP 450 enzyme? - ✔✔Mnemonic for inducers:
|| || || || || || || || || || || || || ||
CRAP GPS induces my rage:
|| || || ||
C: carbamazepine
||
R: Rifampin
||
A: Alcohol
||
P: Phenytoin
||
G:Grisofulvin
P: Phenobarbital
||
S: Sulfonylureas
||
Inhibitors:
Valproate
Ketoconazole
Sulfonamides
Chloramphenicol
Amiodarone
Erythromycin
Quinidine
Grapefruit juice ||
Ultrametabolizers - ✔✔May need higher doses to have therapeutic affect.
|| || || || || || || || ||
Poor metabolizers - ✔✔are at risk of toxicity & adverse drug event.
|| || || || || || || || || || ||
What are the 4 tracts of the basal ganglia that can affect psychiatric or neurological
|| || || || || || || || || || || || || || ||
disorders? - ✔✔Corpus-striatum: || || ||
Globus pallidus: ||
, 2
Substania nigra: ||
Subthalamic nucleus ||
What is the function of the limbic system related to psychiatric disorders. - ✔✔Responsible
|| || || || || || || || || || || || || ||
for emotional expression & motivation, learning & memory (excessive reactions to
|| || || || || || || || || || ||
situations or reduced emotional response = damage to this area).
|| || || || || || || || ||
How would your know if someone's frontal lobe was damaged? - ✔✔Possibility for people
|| || || || || || || || || || || || || ||
who display disinhibition.(poos impulse control and inappropriate behavior), disorganized
|| || || || || || || || ||
behavior (memory deficits and poor planning) and are apathetic (unmotivated). Would
|| || || || || || || || || || ||
show gray matter loss.
|| || ||
Monoamine neurotransmitters common in psychiatric disorders: - ✔✔Serotonin, || || || || || || || ||
norepinephrine and dopamine. || ||
Serotonin: MOA, Sx of deficiency, Sx of excess, drugs - ✔✔MOA: regulates mood, sleep,
|| || || || || || || || || || || || || ||
appetite, sex, pain and instincts. || || || ||
Symptoms of insufficiency: Depression, anxiety, pain sensitivity, carb craving, difficulty
|| || || || || || || || || ||
concentrating, poor sleep, constipation. || || ||
Symptoms of excess: Shivering, diarrhea, muscle rigidity, fever, seizures, irregular HB.
|| || || || || || || || || || ||
Depression, apathy, passivity, insomnia, difficulty concentrating, learning, poor memory,
|| || || || || || || || ||
decision making difficulty, sexual dysfunction.
|| || || ||
Drugs increase serotonin: SSRI's. sertraline, paroxetine, escitalopram, citalopram,
|| || || || || || || ||
fluoxetine.
SNRI's increase serotonin: venlafaxine, duloxetine, desvenlafaxine, milnacipran,
|| || || || || || ||
levomilnacipran.
Dopamine: MOA:Sx insufficiency, SX of excess, drugs. - ✔✔MOA: movement, memory,
|| || || || || || || || || || ||
pleasure/reward, behavior/cognition, attention, inhibition of prolactin production, sleep, || || || || || || || ||
mood, learning. ||
MH 701 Newest exam 1 with precise detailed answers
|| || || || || || || ||
What is the DSM5 - ✔✔Diagnostic and Statistical Manual of Mental Disorders
|| || || || || || || || || || ||
Definitions of disorders based on clinical features.
|| || || || || ||
Diagnostic criteria is a list of clinical features That need to be present for diagnosis.
|| || || || || || || || || || || || || || ||
Increases reliability for diagnostic process.
|| || || ||
Pharmacokinetics - ✔✔What the body does to a drug.(metabolism) Goal is to make is more || || || || || || || || || || || || || || ||
water soluble so it can be excreted.
|| || || || || ||
Pharmacodynamics - ✔✔The study of what the drug does to the body. Interaction between || || || || || || || || || || || || || ||
the drug and the receptor.
|| || || ||
Pharmacogenetics - ✔✔Differences in how individuals metabolize drugs. (Ultra rapid || || || || || || || || || ||
metabolizers or extensive metabolizers of slow metabolizers) || || || || || ||
Toxicity - ✔✔the degree to which a substance is biologically harmful. When a person has
|| || || || || || || || || || || || || || ||
accumulated too much in the blood stream. || || || || || ||
Steady state - ✔✔The time which the concentration of the drug in the body stays consistent.
|| || || || || || || || || || || || || || ||
(usually 4-5 half lives if the drug is given consistently)
|| || || || || || || || || ||
Half-Life - ✔✔Safe dosage interval. The amount of time it takes a drug to be reduced in the
|| || || || || || || || || || || || || || || || || ||
blood by 50%.
|| ||
What are the general classes of psychotropic medications? - ✔✔Antidepressants,
|| || || || || || || || || ||
antipsychotics, mood stabilizers, hypnotics, anxiolytics, cognitive enhancer and stimulants.
|| || || || || || || ||
,2
What is meant by a drug causing an agonist type of reaction at the receptor site? - ✔✔A
|| || || || || || || || || || || || || || || || || ||
drug or medication that binds to a specific receptor producing an effect identical to that
|| || || || || || || || || || || || || || ||
usually produced by the neurotransmitter affecting that receptor. (Drugs are often designed
|| || || || || || || || || || || ||
as receptor agonists to treat a variety of diseases in which the original neurotransmitter is
|| || || || || || || || || || || || || || ||
missing or diminished.) || ||
What is meant by a drug causing an antagonist type of reaction at the receptor site? - ✔✔A
|| || || || || || || || || || || || || || || || || ||
compound that binds to a receptor that blocks or reduces the action of another substance at
|| || || || || || || || || || || || || || || ||
the receptor site involved.
|| || ||
Competitive antagonists: - ✔✔Compete with an agonist for a receptor. EX, drugs for || || || || || || || || || || || || ||
schizophrenia block dopamine 2 receptors, naltrexone and naloxone are opioid antagonists. || || || || || || || || || ||
What is meant by a drug causing a partial agonist type of action at a receptor site? - ✔✔A
|| || || || || || || || || || || || || || || || || || ||
compound that possess affinity for a receptor, but elicits a partial pharmacological response
|| || || || || || || || || || || || ||
at the receptor involved. Partial agonists are often structural analogs of agonist molecules. If
|| || || || || || || || || || || || ||
neurotransmitters a low, partial agonists may behave as agonists.
|| || || || || || || || ||
What is meant by a drug causing an inverse agonist type of action at the receptor site? -
|| || || || || || || || || || || || || || || || || ||
✔✔An inverse agonist is an agent that binds to the same receptors as an agonist for that
|| || || || || || || || || || || || || || || || ||
receptor but produces the opposite pharmacological effect. || || || || || ||
What is the significance of understanding about CYP 450 when prescribing various
|| || || || || || || || || || || ||
medications that may affect this? - ✔✔CYP 450 is an enzyme that helps break down drugs.
|| || || || || || || || || || || || || || || ||
There are some drugs that are either inhibitors or inducers of the CYP 450 enzyme.
|| || || || || || || || || || || || || || ||
The inhibitors inhibit the enzyme from working, therefore decreasing drug metabolism and
|| || || || || || || || || || || ||
can cause toxicity.
|| ||
The inducers speed up the CYP 450 enzyme , therefore increases the drug metabolism and
|| || || || || || || || || || || || || || ||
causes a sub-therapeutic affect. || || ||
,2
What medications are most affected to the CYP 450 enzyme? - ✔✔Mnemonic for inducers:
|| || || || || || || || || || || || || ||
CRAP GPS induces my rage:
|| || || ||
C: carbamazepine
||
R: Rifampin
||
A: Alcohol
||
P: Phenytoin
||
G:Grisofulvin
P: Phenobarbital
||
S: Sulfonylureas
||
Inhibitors:
Valproate
Ketoconazole
Sulfonamides
Chloramphenicol
Amiodarone
Erythromycin
Quinidine
Grapefruit juice ||
Ultrametabolizers - ✔✔May need higher doses to have therapeutic affect.
|| || || || || || || || ||
Poor metabolizers - ✔✔are at risk of toxicity & adverse drug event.
|| || || || || || || || || || ||
What are the 4 tracts of the basal ganglia that can affect psychiatric or neurological
|| || || || || || || || || || || || || || ||
disorders? - ✔✔Corpus-striatum: || || ||
Globus pallidus: ||
, 2
Substania nigra: ||
Subthalamic nucleus ||
What is the function of the limbic system related to psychiatric disorders. - ✔✔Responsible
|| || || || || || || || || || || || || ||
for emotional expression & motivation, learning & memory (excessive reactions to
|| || || || || || || || || || ||
situations or reduced emotional response = damage to this area).
|| || || || || || || || ||
How would your know if someone's frontal lobe was damaged? - ✔✔Possibility for people
|| || || || || || || || || || || || || ||
who display disinhibition.(poos impulse control and inappropriate behavior), disorganized
|| || || || || || || || ||
behavior (memory deficits and poor planning) and are apathetic (unmotivated). Would
|| || || || || || || || || || ||
show gray matter loss.
|| || ||
Monoamine neurotransmitters common in psychiatric disorders: - ✔✔Serotonin, || || || || || || || ||
norepinephrine and dopamine. || ||
Serotonin: MOA, Sx of deficiency, Sx of excess, drugs - ✔✔MOA: regulates mood, sleep,
|| || || || || || || || || || || || || ||
appetite, sex, pain and instincts. || || || ||
Symptoms of insufficiency: Depression, anxiety, pain sensitivity, carb craving, difficulty
|| || || || || || || || || ||
concentrating, poor sleep, constipation. || || ||
Symptoms of excess: Shivering, diarrhea, muscle rigidity, fever, seizures, irregular HB.
|| || || || || || || || || || ||
Depression, apathy, passivity, insomnia, difficulty concentrating, learning, poor memory,
|| || || || || || || || ||
decision making difficulty, sexual dysfunction.
|| || || ||
Drugs increase serotonin: SSRI's. sertraline, paroxetine, escitalopram, citalopram,
|| || || || || || || ||
fluoxetine.
SNRI's increase serotonin: venlafaxine, duloxetine, desvenlafaxine, milnacipran,
|| || || || || || ||
levomilnacipran.
Dopamine: MOA:Sx insufficiency, SX of excess, drugs. - ✔✔MOA: movement, memory,
|| || || || || || || || || || ||
pleasure/reward, behavior/cognition, attention, inhibition of prolactin production, sleep, || || || || || || || ||
mood, learning. ||
